Objective: To explore the influence of optimizing nosocomial infection control management in pharmacy intravenous admixture services(PIVAS) on the quality of infusion and the reduction of nosocomial infection rate. Methods: Data of 1 586 patients with PIVAS from January 2015 to December 2016 (before optimized management) were collected. In addition, data of 1 865 patients (after optimized management) from January 2017 to January 2019 were extracted. PIVAS had 25 staff before and after optimized management. The difference of intravenous infusion quality and hospital infection rate before and after optimized management were compared. Results: Compared with that before the optimized management, the satisfaction of the packaging of chemotherapy drugs, infusion preparation quality and operating platform environment after the optimized management was higher (P<0.05), and the incidence of nosocomial infection was lower than that before the optimized management (P<0.05). Conclusion: PIVAS optimized the nosocomial infection control management, the quality of intravenous infusion was effectively improved, containing the occurrence of nosocomial infection, and ensuring the safety of patient medication. The occurrence of nosocomial infection was curbed and the safety of medication was ensured.