Objective: To explore the role of clinical pharmacists participating in the anti-infective medication for patient with Aspergillus Niger pulmonary infection. Methods: The clinical pharmacist participated in the process of anti-infective medication for a patient infected by Aspergillus niger, who was detected by next-generation sequencing, assisting physicians to adjust anti-infective medication plan, and its pharmaceutical care. Results: After amphotericin B treatment, the antifungal medication of Aspergillus Niger infective patient was effectively controlled; the pulmonary lesions tended to close, and the condition was relatively stable. Conclusion: Clinical pharmacists participated in clinical antifungal therapy for patients with Aspergillus Niger to ensure the safety and effectiveness of medication.
Key words
Aspergillus Niger /
pulmonary infection /
amphotericin B /
pharmaceutical care
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 中华医学会器官移植学分会.器官移植受者侵袭性真菌病临床诊疗技术规范(2019 版)[J].器官移植,2019,10(3):227-236.
[2] Aguilar CA, Hamandi B, Fegbeutel C, et al. Clinical risk factors for invasive aspergillosis in lung transplant recipients: results of an international cohort study[J]. J Heart & Lung Transplant, 2018, 37(10):1226-1234.
[3] Atchade E, Jean-baptiste S, Houze S, et al. Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation[J]. Med Mycol Case Rep, 2017,18(17): 4-7.
[4] 冯靖,吴波,张静,等.两性霉素B经支气管镜肺部局部注人的理论依据和操作流程[J].天津医药,2019,47(4):424-427.
[5] 中华医学会器官移植学分会,中国医师协会器官移植医师分会.中国实体器官移植受者侵袭性真菌病临床诊治指南(2016年版)[J].中华器官移植杂志,2016,37(5):300-305.
[6] IDSA. Practice guidelines for the diagnosis and management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America[J]. Clin Infect Dis, 2016, 63(4):e1-e60.
[7] Winkler J, Muller U, Nenoff P, et al. Treatment of invasive pulmonary Aspergillosis in neutropenic patients by additional bronchoscopic amphotericin B instillation[J]. Intervent Pulmonol, 2007, 74(6):663-673.
[8] 王凯. 经纤维支气管镜肺泡灌洗两性霉素B联合伏立康唑在侵袭性肺真菌病中的应用[J].中国现代医药杂志,2016,10:33-35.
[9] 伍定辉,苏伟明.经气管镜灌注两性霉素B治疗结核空洞内曲霉菌球疗效观察[J].中国卫生标准管理,2016,15:109-112.
[10] Yamada H, Kohno S, Koga H, et al. Topical treatment of pulmonary aspergilloma by antifungals: relationship between duration of the disease and efficacy of therapy[J]. Chest, 1993, 103(5):1421-1425.
[11] ERS/ESCMID. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management[J]. Eur Respir J, 2016, 47(1):45-68.
[12] Mitomo H, Sakurada A, Matsuda Y, et al. Endobronchial topical amphotericin B instillation for pulmonary chromomycosis after lung transplantation: a case report[J]. Transplantation Proceedings, 2018, 50(3): 939-942.
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}