Objective: To analyze the clinical characteristics of adverse drug reactions (ADRs) related to antibacterial drugs in the hospital and propose response strategies, so as to provide reference for safe use of antibacterial drugs in clinical practice. Methods: A total of 238 patients who developed ADR after using antibacterial drugs at Yong'an Caoyuan Health Center from November 2017 to October 2020 were selected as the research objects. The incidence of ADR after using antibacterial drugs in patients of different age groups was counted to analyze the main types of antibacterial drugs that caused ADR, clinical manifestations and causes of patients, and measures to reduce drug-induced damage. Results: Among the 238 patients, the majority of ADR patients caused by antibacterial drugs were over 60 years old, followed by >50-60 years old and 18-30 years old. Among the varieties of antibacterial drugs used, there were 98 cases of cephalosporins (41.18%) and 47 cases of penicillin (19.75%). A total of 72 cases (30.25%) of ADR patients mainly involved skin tissue, with symptoms such as papules, itching, redness and swelling, 58 cases (24.37%) of the digestive system, with symptoms such as abdominal pain, nausea, vomiting and abdominal distension, and 47 cases (19.75%) of the nervous system, with main clinical manifestations such as dizziness, headache, discomfort and insomnia. The main causes of antibacterial ADR were 161 cases (67.65%) without conducting drug susceptibility tests, 56 cases (23.53%) with excessive dosage and 11 cases (4.62%) with no indication of medication. Conclusion: The incidence of antibacterial ADR varies among different age groups, and patients often experience different degrees of clinical symptoms due to the influence of drug types. Multiple clinical measures should be taken to ensure the rational use of antibacterial drugs, reduce drug-induced damage, and improve medication safety.