Objective: To investigate and analyze the epidemiological characteristics of Dengue fever (DF) in Xingan, Jiangxi Province from 2018 to 2021 and propose preventive measures, so as to provide reference for prevention and treatment of DF. Methods: By using "China Disease Prevention and Control Information System", the epidemiological data of DF in Xingan from 2018 to 2021 was collected, and the epidemiological characteristics and countermeasures of DF in the area were analyzed. Results: The epidemiological survey results showed that 375 DF patients were reported in the area from 2018 to 2021, with no deaths, including 71 imported cases (18.93%) and 304 local cases (81.07%), with the incidence rate rising year by year (χ²=184.303, P<0.05). The peak period for annual DF case reports was from July to November; 42.67% of patients suffering from DF were middle-aged and young patients aged above 30-40 years old. The ratio of male to female patients was 1:1. The incidence rate of DF in farmers was the highest among all occupational groups (31.20%). The results of serum nucleic acid detection and typing showed that infection of dengue virus type I (DENV-1) accounted for 57.33%, followed by DENV-2 (24.53%). Conclusion: The incidence rate of DF in Xingan, Jiangxi Province is on the rise year by year, which is related to people gathering in a certain period of time. The health administrative department should actively carry out prevention and control knowledge publicity, infection source monitoring, mass prevention and mass control and other measures to effectively curb the spread of DF.