KANGGANRAN YAOXUE

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  • 2019 Volume 16 Issue 5
    Published: 25 May 2019
      
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  • Research Advances on Pharmacological Action and Clinical Efficacy of Matrine Against Lungs Cancer
    ZHANG Ming-fa, SHEN Ya-qin
    2019, 16(5): 737-742.
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Matrine inhibits proliferation and induces apoptosis in various lungs cancer cells (A549 cells, SPC-A-1 cells, NIC-H460 cells, LTEPa-2 cells, SK-MES-1 cells, PG cells and Lewis cells). Matrine induces apoptosis of lungs cancer cells by the mechanisms of inhibiting PI3K/Akt signaling pathway, and telomerase activity, and the expression of human telomerase reverse transcriptase (hTERT), and improving autophagy. Matrine blockades the growth and metastasis of cancer cell by decreasing the activity of EGFR-TPK, as well as down-regulating the expression of angiogenesis related protein HIF-1α, VEGF, and matrix metalloproteinases, and adhesion molecules CD44 and CD49, to reduce microvascular formation in cancer tissue, and abilities of adhesion, migration, and invasion. In clinic matrine promotes clinical efficacy of chemotherapeutics against lung caner. The clinical literatures of the pharmacological effects of matrine on lungs cancer have been reviewed and its research progress is analyzed. It provides reference for clinical research and development of new indications of matrine in the treatment of lung cancer.
  • Study on Preparation of Micro-emulsion-Based Gel of β-asarone and Its Release in Vitro
    ZHAO Ying, Wang-li
    2019, 16(5): 743-747.
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    Objective: To study the preparation of micro-emulsion-based gel of β-asarone and its release in Vitro.Methods: The microemulsion area size was indicators, the types of oil phase and mixed emulsifier ratio were factor,the microemulsion prescription was screened using solubility and the pseudo-ternary phase diagram; the microemulsion-based gel was made from the suitable gel-base; the content determination, the physicochemical property, stability and pharmacokinetic of microemulsion-based gel were investigated. Results: The oil phase was Capryol-90, emulgator was Tween-80, co-emulsifier was glycerol, microemulsion-based gel was made from Poloxamer and Carbopol; the inspection indexes conformed to the requirements of the nasal drug delivery, and the cmax was 0.65 μg/mL in rat Vivo. Conclusion: The preparation of β-asarone microemulsion-based gels have characteristics of quality stabilization and the drug release rapid and everlasting. It can be used as the preparation and application of intranasal drug dosage form.
  • Study on Suppression Effect of Beta-elemene against Plasmodium Falciparum in Vitro*1
    XUAN Yu-ting, YU Zhong-ting, ZHAO Jia-yao, WANG Yan-hong, ZHOU Hong-chang
    2019, 16(5): 748-750.
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    Objective: To study the antimalarial activity of β-elemene in vitro, a novel non-cytotoxic antitumor drug isolated from the Traditional Chinese Medicinal herb Rhizoma Zedoariae. Methods: Chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2) strains of Plasmodium falciparum were tested using β-elemene and the fluorescence-based SYBR Green I assay was used to calculate the growth inhibition. Results: Compared with non-treated control, β-elemene can arrest the parasites growth at 10 μg/mL,and the parasites could be significantly inhibited at 40 μg/mL. The 50% inhibitory concentration (IC50) values of β-elemene were (13.60±0.540) μg/mL for 3D7 and (12.59±0.54) μg/mL for Dd2, respectively. Conclusion: These results demonstrated that β-elemene showed good antimalarial effect, and the β-elemene seemed to be of special interest for further antimalarial studies.
  • Study on Determination of Blood Concentration of Quetiapine in Patients with Schizophrenia and Its influence on Clinical Efficacy*1
    WANG Ping, ZHANG Zhong-dong, ZHANG Ping
    2019, 16(5): 751-754.
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    Objective: To study the change of daily blood drug concentration in patients with mental illness after taking quetiapine and its influencing factors on clinical efficacy, and to provide a reference for the rational use of quetiapine in clinic. Methods: Data of 786 cases of mental patients treated with quetiapine from January to December 2018 were extracted. The results of routine blood concentration test of quetiapine, gender, age and dose of the patients were calculated, and the relationship between blood concentration of quetiapine, gender, age and dose were analyzed. Results: The most common dose of quetiapine was between 0 and 150 mg, everday (25.45%), and then was between 150 and 300 mg,(24.43%), 450 and 600 mg (21.76%), 300 and 450 mg, everday (11.96%), and 4 doses accounted for 83.60% of the total constituent ratio. The plasma concentration of quetiapine was mainly concentrated between 0 and 150 ng/mL (57.76%), and then between 150 and 300 ng/mL (30.28%), and 2 concentrations accounted for 88.04% of the total composition ratio. The average plasma concentrations of the patients were increased with the increase of the dosage, and the concentration-dosage ratios were reduced with the increase of the dosage. With the increase of age, the concentration-dosage ratios showed an increasing trend. Conclusion: The monitoring of the daily blood drug concentration of quetiapine can not only promote the better clinical efficacy of drugs, but also can promote the rational use of antipsychotic drugs, and at the same time can avoid or reduce the occurrence of adverse reactions.
  • Analysis on Related Factors of Clinical Medication of Special-grade Antibacterial Drugs in A Hospital in 2018
    CHU Lai-sung
    2019, 16(5): 755-757.
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    Objective: To analyze the related factors of clinical medication of special-grade antibacterial drugs in a hospital in 2018. Methods: Relevant data of 80 patients with clinical use of special grade antibacterial drugs in hospitals from January 2018 to December 2018 were extracted. The name, specification, dosage, amount and department distribution of the drugs used by the patients were counted, and the use of antibacterial drugs was analyzed. Results: In 2018, the dosage and sales amount of the hospital's special-use grade antibacterial drugs were the highest with meropenem for injection, and the lowest with imipenem sistatin sodium for injection. Special grade antibacterial drugs were commonly used in the intensive care unit, joint department, hematological oncology department, emergency room observation, general medicine department, surgery department, rehabilitation department, spinal department and orthopaedic trauma department. In addition to hematological oncology department, other departments were single drug use. Among the 80 randomly selected patients, 13 patients had bacterial culture, accounting for 16.25%, and 16 doctors without senior professional titles, accounting for 20.00%. Conclusion: There are still serious unreasonable drug use phenomena in the use of special-use grade antibiotics in hospitals, which still need further strengthening management.
  • Influence of Pharmaceutical Care on Efficacy of Clinical Anti-infection Medication in NICU and Its Satisfaction on Treatment
    ZHONG Chun-yuan, LI Zhi-qing, HUANG Zhu, XIE Qi
    2019, 16(5): 758-760.
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    Objective: To evaluate the influence of pharmaceutical care on efficacy of clinical anti-infection medication in neonatal intensive care unit (NICU) and its satisfaction on treatment. Methods: The data of 200 NICU patients admitted from February 2015 to October 2016 were selected as the non-pharmaceutical care group, and the data of 200 NICU patients admitted fom February 2017 to October 2018 were selected as the pharmaceutical care group. The differences of the incidence of infection and satisfaction with treatment between the two groups were compared. Result: Among the 200 cases in the pharmaceutical care group, 12 cases were infected respiratory tract, skin, gastrointestinal tract, oral cavity and other infections, and the incidence rate (6.00%) was significantly lower than that in the non-pharmaceutical care group (27.00%) (P<0.05). The family members of the patients were more satisfied with the treatment than the non-pharmaceutical care group (P<0.05). Conclusion: Anti-infection pharmaceutical care could effectively reduce the incidence of infection, and the satisfaction rate of family members in NICU were improved.
  • Evaluation of Sequential Moxifloxacin Therapy on Clinical Efficacy in Elderly Patients with LRTI and Its Influence on Inflammatory Cytokines
    FENG Er-xiang
    2019, 16(5): 761-763.
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    Objective: To evaluate the clinical efficacy of sequential moxifloxacin therapy in elderly patients with lower respiratory tract infection (LRTI) and its influence on inflammatory cytokines. Methods: Data of 150 elderly patients with LRTI admitted from August 2017 to July 2018 were selected and divided into control group and observation group according to different treatment methods, with 75 cases in each group. Patients in the control group were treated with sequential therapy of levofloxacin, while patients in the observation group were treated with sequential therapy of moxifloxacin. The total effective rate of the two groups was compared 7 days after treatment, as well as the changes of serum inflammatory factors (IL-6, IL-8 and TNF-α) before and after treatment was also compared. Results: The total effective rate (90.67%) in the observation group was higher than that in the control group (78.67%) (P<0.05), and the serum IL-6, IL-8 and TNF-α levels after treatment were all lower than those in the control group (P<0.05). No serious adverse drug reactions occurred in the two groups. Conclusion: The efficacy of sequential moxifloxacin therapy in the treatment of elderly patients with LRTI is better than that of levofloxacin therapy. It helps to improve the level of serum inflammatory factors and the security is higher.
  • Analysis on Related Factors of 417 Cases of Adverse Drug Reaction in a Children's Hospital in 2018
    YAO Hua, WANG Feng-jiao, MAO Chen-mei
    2019, 16(5): 808-811.
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    Objective: To analyze the related factors and the occurrence characteristics of 417 cases of adverse drug reaction (ADR) reported by the hospital in 2018, and to provide a reference for clinical rational drug use to ensure the medication safety of children. Methods: 417 voluntary and effective ADRs reports in 2018 were collocted by the hospital OA adverse reaction reporting system. The sex, age, route of administration, variety of drugs involved, system/organ involved, correlation evaluation and other related factors were analyzed. Results: Among 417 cases of effective ADRs, new and severe ADRs accounted for 39.33%. The ratio of male to female children were 1.9:1, and the age ranged from 7 d to 17 years old, that is: 64 cases<1 years old were 15.35%, 192 cases>1 to 4 years old were 46.04%; 99 cases>4 to 8 years old were 23.74%, and 62 cases>8 to 17 years old were 14.87%. The incidence of venous route was 66.67% and that of non-venous route was 33.33%. The TOP 3 drug categories were anti-infective drugs (36.21%), proprietary Chinese medicines (15.35%), the electrolyte and nutritional supplements medication (8.39%). Conclusion: The incidence of new and serious ADRs in 2018 was higher than that in 2017, indicating the continuous improvement of the quality of hospital ADRs reports, the standardization of the clinical use of anti-infective drugs, proprietary Chinese medicines and nutrition-assisted drugs in pediatrics, and the adoption of multi-directional measures to ensure the safety and effectiveness of medication for children.
  • Clinical value of serum calcitonin monitoring in antibiotic therapy of pulmonary infection
    YU Da-yan, YAN Liu, ZHANG Yan-li
    2019, 16(5): 826-828.
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    Objective: To explore the clinical application value of serum procalcitonin (PCT) level monitoring in guiding the antibiotics treatment in patients with pulmonary infection. Methods: Data of 72 patients with pulmonary infection admitted from January 2017 to November 2018 were selected. According to the treatment method and PCT test results, the patients were randomly divided into control group and observation group, with 36 patients in each group. Patients in the control group were given routine treatment with antimicrobial agents, and patients in the observation group were given antimicrobial agents under the guidance of PCT level monitoring. To compare the difference between the two groups in the duration of antimicrobial use and the total effective rate, as well as the changes in CRP and WBC levels. Results: The treatment time and hospitalization time of the observation group were shorter than those of the control group (P<0.05). The cost of antibacterial treatment and the total cost were lower than those of the control group (P<0.05). The total effective rate was higher than that of the control group (P<0.05). There was no significant difference in CRP and WBC levels between the two groups (P>0.05). Conclusion: For patients with pulmonary infection, monitoring the PCT level to guide the use of clinical antibiotics can shorten the treatment time of antibiotics and promote the recovery of patients.
  • Evaluation on Clinical Efficacy of Anti-infection of Ceftriaxone Sodium Combined with Azithromycin in Patients with Pneumonia
    WANG Zhe, XIN Zhi-ming, LIU Qu
    2019, 16(5): 829-831.
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    Objective: To evaluate the clinical efficacy of anti-infection of ceftriaxone sodium combined with azithromycin in patients with pneumonia. Methods: Data of 80 cases of pneumonia patients admitted from September 2017 to September 2018 were selected. According to different treatment methods, they were randomly divided into control group and treatment group, with 40 cases in each group. Patients in the treatment group were given ceftriaxone sodium combined with azithromycin, while patients in the control group were treated with azithromycin alone. The total effective rate and recovery time of clinical symptoms were compared between the two groups. Results: The total effective rate of the treatment group was higher than that of the control group (P<0.05), and the recovery time of clinical symptoms was earlier than that of the control group (P<0.05). Conclusion: The combination of azithromycin and ceftriaxone sodium in the treatment of pneumonia patients is more effective, effectively promoting the recovery of clinical symptoms of patients.