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  • 2019 Volume 16 Issue 10
    Published: 25 October 2019
      
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  • Research Advances in Pharmacological Effects of Oxymatrine on Tumor Cell Proliferation in Patients with Gynecology Cancer
    ZHANG Ming-fa, SHEN Ya-qin
    2019, 16(10): 1657-1662. https://doi.org/10.13493/j.issn.1672-7878.2019.10-001
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    Oxymatrinee inhibits proliferation and induces apoptosis association with dosage on mammary cancer MCF-7 cells, ovarian carcinoma SKOV-3 cells, HO-8910 cells, NuTu19 cells, PM-2 cells, cervical carcinoma HeLa cells, SiHa cells and endometrial carcinoma Ishikawa cells. Oxymatrine inhibits also the adhesion and invasion of these cancer cells. Oxymatrine induces apoptosis of gynecologic tumors cells by controlling miR-125b/STAT3 pathway, up-regulating p38MAPK pathway and down-regulating Akt pathway or Wnt/β-catenin pathway. That oxymatrine inhibits proliferation of cancer stem cell which is more powerful than non-cancer stem cell in cancer cells. Low concentration of oxymatrine inhibits tumor cells to secrete immunodepressive molecules, and to express P-glycoprotein; it is a mechanism that oxymatrine promotes efficacy of radiotherapy and chemotherapy. The literatures of pharmacological effects of oxymatrine on tumor cells proliferation in tumor patients were reviewed and the research progress was analyzed.
  • Study on Stability of Sodium Nitroprusside for Injection with High Concentration in Different Light-proof Injectors*1
    GUO Yin, LI Yong-tao
    2019, 16(10): 1663-1667. https://doi.org/10.13493/j.issn.1672-7878.2019.10-002
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    Objective: To study the stability of sodium nitroprusside for injection (SNP) with high concentration in light-proof injector and white injector wrapped in aluminum foil, and to provide a reference for rational drug use in clinical practice. Methods: Six groups of SNP were prepared respectively according to the concentration of clinical use. The stability of SNP solution was studied in two different environments with different storing time points, and the assessment indices included the appearance, insoluble particles, pH value and SNP content. Results: Six groups SNP of clarity all meet the requirements, no visible foreign body was found, no change was found in colour, the rate of decline was fastest in shanding infusion set. the content of high concentration of SNP（1 500 μg/mL） was slowest. Conclusion: At room temperature and sodium nitroprusside for injection was dissolved in 5% glucose injection. The solution with a concentration of 1 000 mg/mL was prepared and placed in a white syringe wrapped in aluminum foil, which was relatively stable within 28 h.
  • Analysis on Distribution and Resistance of Pathogenic Bacteria of Wound Infection in Patients with Tumor from 2016 to 2018 in a Hospital
    OU-YANG Qun-fang, ZHENG Chun-mao
    2019, 16(10): 1668-1673. https://doi.org/10.13493/j.issn.1672-7878.2019.10-003
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    Objective: To analyze the distribution and resistance to antimicrobial agents of pathogenic bacteria of wound infection in patients with tumor from 2016 to 2018 in a hospital. Methods: The Data of 4 039 patients with incision Ⅰ class tumor surgery were selected from 2016 to 2018 (including 1 381 cases in 2016, 1 255 cases in 2017 and 1 403 cases in 2018). The general data of the patients were statistically analyzed to explore the influencing factors of infection and the distribution of bacteria causing incision infection as well as resistance to the antimicrobial. Results: Age, preoperative complications, immune function, preoperative chemorheology, history of radiotherapy, preoperative hospital stay and operation time, perioperative use of antimicrobial agents and surgical site were correlated with postoperative incision infection in 4 039 patients. Enterobacteriaceae bacteria were the main pathogenic bacteria, followed by gram-positive cocci, and Escherichia coli; Klebsiella pneumoniae producing beta-lactamase. Escherichia coli still maintained a low resistance rate to carbapenems, amikacin, ceftetan, cefoperazone-sulbactam and piperacillin tazobactam. The drug resistance rate of Klebsiella pneumoniae was lower than that of Escherichia coli and higher than that of penicillin, cephalosporin and ceftriaxone. The drug resistance rates of Staphylococcus aureus and Staphylococcus epidermidis to methicillin were 20% and 30%, respectively. However, the drug resistance rates of Staphylococcus aureus and staphylococcus epidermidis to methicillin and vancomycin were lower than those of penicillin, clindamycin and tetracycline. Conclusion: In view of multi-drug resistance of bacteria in the infected site of incision and controllable factors affecting incision infection, infection control department of hospital should take effective prevention and control measures to ensure the occurrence of postoperative nosocomial infection.
  • Analysis on Perioperative Medication of Antimicrobial Agents in 240 Patients with Cesarean Section
    LI Xiao-lan
    2019, 16(10): 1674-1678. https://doi.org/10.13493/j.issn.1672-7878.2019.10-004
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    Objective: To analyze the perioperative medication of antimicrobial agents in patients with cesarean section, and to provide a reference for rational use of antibiotics in clinic. Methods: The data of 240 cesarean section patients admitted from January 2017 to December 2018 were collected. The variety, frequency, duration, combination of antibiotics, postoperative body temperature, blood routine, CRP and other inflammatory indicators were statistically analyzed. Results: In 240 cases of cesarean section operation patients, perioperative prophylactic medication of antibiotics was used;There were 5 varieties involved in the drug use. The TOP 3 antibacterial drugs were cefezolin, cefuroxime and cefexitin. The average duration of antibacterial drug use was 2.36 days, the co-use rate of antibacterial drugs was 17.92%, and the incidence of postoperative infection was 3.33%. Conclusion: The perioperative prophylactic medication of antimicrobial agents in patients with cesarean section in hospital was basically reasonable, but there were still some improper drug selection and improper combined use, and a small number of patients had a long medication time.
  • Clinical Analysis on Liver Injury Induced by Anti-TB Drugs in Chronic Liver Disease Patients with TB and Its Influence on Anti-TB Treatment
    LI Yang, LIU Jia
    2019, 16(10): 1679-1682. https://doi.org/10.13493/j.issn.1672-7878.2019.10-005
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    Objective: To analyze the clinical characteristics of drug-induced liver injury induced by anti-tuberculosis(anti-TB) drugs in pulmonary tuberculosis patients with chronic liver disease and its influence on anti-TB treatment. Methods: The data of 926 newly diagnosed patients with tuberculosis admitted from January 2014 to December 2018 were selected. The correlation between drug-induced liver damage and the presence or absence of chronic hepatitis, different types of chronic hepatitis, the degree of liver damage and its clinical type were analyzed, as well as the impact of anti-tuberculosis drug treatment in patients treated with the formal anti-tuberculosis program (2HREZ/4HR) was also analyzed. Results: 926 patients with primary tuberculosis (236 patients with chronic hepatitis and 690 without underlying liver disease) showed drug-induced liver damage in 690 patients without underlying liver disease (30.87%).Liver damage occurred in 104 cases (44.07%) among 236 cases with chronic hepatitis. The incidence of liver injury in pulmonary tuberculosis patients with chronic liver disease was significantly higher than that in patients without underlying liver disease (P<0.05). The incidence of drug-induced liver damage was high and the degree of liver function damage was serious in pulmonary tuberculosis patients with chronic hepatitis B. Drug-induced liver damage was more likely to occur during the intensification period of anti-tuberculosis drug treatment. Conclusion: The changes in liver function in patients with chronic liver disease should be closely monitored during anti-TB drug therapy, especially during the anti-TB intensification period. Anti-TB drug treatment regimen should be adjusted or discontinuation of anti-TB medication, if necessary, so as not to cause irreversible serious consequences.
  • Influence of Case Management Mode on Compliance with Oral Antiviral Medication in Patients with Chronic Hepatitis B
    HUI Fen, TAO Yuan-yuan, CAI Dong-hui
    2019, 16(10): 1718-1721. https://doi.org/10.13493/j.issn.1672-7878.2019.10-017
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    Objective: To explore the influence of case management mode on compliance with oral antiviral medication in patients with chronic hepatitis B (CHB). Methods: Data of 136 cases of CHB patients admitted from June to December 2016 (as the former group) and data of 136 cases of CHB patients admitted from January to July 2017 (as the latter group) were selected. After the management mode, patients in the group established a case management file of CHB oral antiviral therapy after discharge. The understanding rate of disease-related knowledge and antiviral drug knowledge before and after the management mode of patients in the two groups, as well as the differences in compliance with oral antiviral drug medication were compared. Results: The understanding rate of CHB related knowledge and antiviral medication and the compliance to treatment were significantly higher in the post-mode group than in the pre-model group (P<0.05). Conclusion: Case management mode was adopted to improve the understanding rate of CHB patients' knowledge of CHB diseases and treatment compliance, and reduced the occurrence of adverse drug reactions and complications ensuring the completeness and effectiveness of patients' medication.
  • Literature Analysis of Clinical Diagnosis in 68 Patients with Ocular Syphilis and Its Prevention and Treatment Countermeasure*1
    DAI Jun, XIA Wei, WU Min-zhi, MO Xing-fan, LI Jing-jing, FENG Zhi1, HE Fang-hua, WANG Qian-qiu, ZHANG Xue-hua
    2019, 16(10): 1739-1743. https://doi.org/10.13493/j.issn.1672-7878.2019.10-024
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    Objective: To analyze the clinical characteristics of ocular syphilis and to provide a reference for clinical prevention and treatment of ocular syphilis. Methods: Key words such as "ocular syphilis", "clinical diagnosis", "anti-syphilis treatment", "treponema pallidum", "optic neuritis" and "optic atrophy" in CNKI, Wangfang Data and other databases were searched by computer. The literatures related to ocular syphilis in recent 10 years at home and abroad have been searched, and statistical software Excel 2007 and SPSS 20.0 have been used to analyze the ophthalmic examination, dermatological examination and pathological examination results of lumbar puncture. Results: According to the inclusion criteria and extraction of effective information, 68 patients were eventually included in the 12 articles, most of whom were posterior segment lesions, with optic nerve atrophy accounting for the majority. Conclusion: The ocular lesions of syphilis were diverse and lack of specificity. For the cause of unknown vision loss, eye inflammation and other diseases should be excluded from the existence of syphilis; syphilis should be regarded as a distinguishing factor of optic neuritis. Once it is diagnosed as ocular syphilis, standardized anti-syphilis therapy should be adopted based on the clinical pathway of neurosyphilis.