KANGGANRAN YAOXUE

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  • 2020 Volume 17 Issue 5
    Published: 25 May 2020
      
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  • Research Advances in Clinical Pharmacological Actions of Sophocarpine on Respiratory and Digestive Disease
    ZHANG Ming-fa, SHEN Ya-qin
    2020, 17(5): 621-626. https://doi.org/10.13493/j.issn.1672-7878.2020.05-001
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    Sophocarpine has the actions of hepatic protection, anti-ulceration, anti-diarrhea, anti-colitis, anti-asthma and improving lungs function. The anti-inflammation action is a common mechanism of above-mentioned actions. In clinic sophocarpine has been tried on treatment for bronchial asthma and asthmatic chronic bronchitis, its curative effect is equal or better than aminophylline, and its adverse drug reactions is smaller than aminophylline. Owing to sophocarpine possessing antiviral actions, authors hope to recommend it for the treatment of viral pneumonia. In this paper, the literatures of the clinical pharmacological effects of sophoridine on respiratory and digestive diseases have been reviewed, and its research progress have been analyzed.
  • Study on Determination Methodology of Sulfur Dioxide Residues in 26 Kinds of Traditional Chinese Medicinal Materials by IC Method*1
    TAO Song, LIU Jing, LIU Ling
    2020, 17(5): 627-631. https://doi.org/10.13493/j.issn.1672-7878.2020.05-002
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    Objective: To establish an ion chromatography (IC) method for the determination of sulfur dioxide（SO2） residues in 26 kinds of Traditional Chinese Medicinal materials. Methods: The samples were extracted by distilliation with acid and absorbed with 3% hydrogen peroxide solution. Test solution was separated by Ionpac AS18 column using NaOH and H2O as eluent and detected with conductivity detector. Velocity of flow was 0.25 mL/min. The injection volume was 10 μL. The qualitative analysis was made by comparing the reservation time, quantitative analysis was made by standard curve. Results: The linear range of sulfate (SO42–) radical was between 1.0 and 100 μg/mL(r=0.999 9), the average recovery of Dioscoreae Rhizoma, Lilii Bulbus and Acanthopanacis Cortex were 94.14 %, 94.72% and 94.15%. the limit of detection was 0.02 mg/kg, and the limit of quantitation was 0.12 mg/kg. Conclusion: The method is simple, rapid and sensitive. It shows better reproducibility and accuracy.
  • Influence of Direct-acting Antivirals on Liver and Kidney Function and Blood Routine Index in Patients with Hepatitis C*1
    DAI Zhao-dong, CHEN Hong-bo, WANG Yi-fan
    2020, 17(5): 632-636. https://doi.org/10.13493/j.issn.1672-7878.2020.05-003
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    Objective: To explore the changes of liver and kidney function and blood routine in patients with chronic hepatitis C before and after treatment with direct acting antivirals (DAAs), so as to evaluate its influence on liver and kidney function and blood routine parameters of chronic hepatitis C patients. Methods: 107 patients with hepatitis C who received DAAs in Jurong Hospital Affiliated to Jiangsu University from January 2015 to December 2018 were enrolled to conduct a one-to-one questionnaire survey to every patient. Information about liver and kidney function and blood routine before and after treatment were also collected and the changes of each indicator were analyzed. Result: After DAAs treatment, liver function indicators such as ALT, AST, total bilirubin, direct bilirubin, alkaline phosphatase and glutamyltranspeptidase were significantly improved in HCV patients (P<0.05), and the results were basically consistent in each gender stratification. The abnormal rate of ALT decreased from 64.15% to 3.77%, AST from 66.98% to 5.66%, and glutamyltranspeptidase from 51.92% to 15.38%. In addition, some blood routine indicators such as monocyte ratio, neutrophil count, mean platelet volume, platelet distribution width and platelet count were different in the two groups before and after treatment, but the changes were within the normal value range. Conclusion: DAAs can significantly improve liver function in hepatitis C patients, and no adverse effects were found on renal function and blood routine indicators. So, they are worthy of popularization in hepatitis C patients of the Han nationality.
  • Determination of Sulfamethoxazole by Dead-stopping Titration and Evaluation of Its Uncertainty
    LIU Hua-ming, ZHOU Zhen-yu
    2020, 17(5): 637-640. https://doi.org/10.13493/j.issn.1672-7878.2020.05-004
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    Objective: To establish a method for uncertainty assessment of concentration of sulfamethoxazole by dead-stopping titration. Methods: A mathematical model was established to determine the content of sulfamethoxazole by dead-stopping titration, and the factors affecting the determination results were evaluated. Results: Through the analysis of each variable, the content of sulfamethoxazole was 99.92%, and the extended uncertainty was U'c=k×u'c=0.234 1%, so the content range was (99.92±0.23)%. Conclusion: A method for determining the content and uncertainty of sulfamethoxazole by dead-stopping titration was established. It is beneficial to control drug quality.
  • Analysis on Bacterial Culture and Resistance of 14 046 Clinical Specimens of Inpatients in the First Three Quarters of 2019
    WANG Ai-xia, ZHANG Jin-xia, WANG Ya-feng
    2020, 17(5): 641-645. https://doi.org/10.13493/j.issn.1672-7878.2020.05-005
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    Objective: To investigate the composition and drug resistance of isolated bacteria in hospital, and to promote the rational use of antibiotics. Methods: Data of 14 046 test specimens of inpatients in the first three quarters of 2019 were collected, the results of detection and identification of isolated strains and drug sensitivity test in clinical samples were calculated, and the distribution of pathogenic bacteria and their resistance to different antimicrobial drugs were analyzed. Results: Among the 14 046 samples, 2 295 strains of non-duplicative pathogens were isolated, in which 667 strains of fungi and 1 628 strains of bacteria (32.62% gram-positive bacteria and 67.38% gram-negative bacteria) were isolated. The detection rate of respiratory (sputum) specimens was the highest, followed by vaginal swab specimens, urine specimens, blood specimens, etc.. The TOP 5 pathogens isolated from gram-positive bacteria were Staphylococcus aureus, Streptococcus agalactiae, Coagulase negative Staphylococcus, Streptococcus pneumoniae and Enterococcus faecalis. The isolation rate of methicillin-resistant Staphylococcus aureus (MRSA) was 15.90%. Enterococcus faecalis had the most severe drug resistance, and no gram-positive strain resistant to vancomycin and linezolid was detected. The TOP 5 isolated gram-negative bacteria were Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii. The separation rates of Escherichia coli and Klebsiella pneumoniae were 27.5% and 2.5%, respectively. Escherichia coli and klebsiella pneumoniae were highly sensitive to carbapenems. The drug resistance rate of Pseudomonas aerubicans to imipenem and cefepime was 12.2%, and that of Acinetobacter baumannii to imipenem, gentamicin and cefepime was over 62.5%. Conclusion: The level of bacterial resistance is lower than that in the whole country, but it is still necessary for hospital to standardize the collection and examination of clinical specimens and to strengthen the monitoring of bacterial resistance and the control of antimicrobial drugs, so as to promote the rational use of clinical antimicrobial drugs.
  • Analysis and Evaluation of Rationality on Clinical Medication of Anti-tumor Drugs in 114 Medical Orders of Tumor Patients
    ZHANG Jing, SHI Xiang-kui, HUANG Ting, JIANG Ying-feng, LIU Yuan, CAO Zheng
    2020, 17(5): 646-650. https://doi.org/10.13493/j.issn.1672-7878.2020.05-006
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    Objective: To analyze and evaluate the rationality of clinical medication of anti-tumor drugs, and to provide reference for rational use of antitumor drugs. Methods: 114 prescriptions containing anti-tumor drugs were taken from tumor patients admitted to gynecology department from July to December 2018. The clinical use of anti-tumor drugs prescribed by doctors was analyzed, and the rationality, reasons and countermeasures of the clinical use of anti-tumor drugs (such as solvent variety, solvent quantity, drug delivery order, intravenous infusion rate, etc.) were evaluated according to the "comment standard". Results: Among the 114 medical orders for the medication of anti-tumor drugs, 103 medical orders were reasonable (the reasonable rate was 90.35%), and 11 medical orders were unreasonable (9.65%). The reasons for unreasonable drug use were: 2 cases (18.18%) were used beyond the authority of doctors, 2 cases (18.18%) were used at inappropriate infusion rate, 4 cases (36.36%) were given at inappropriate infusion sequence, 1 case (9.09%) was not fully hydrated, and 2 cases (18.18%) were improperly kept and used for infusion. Conclusion: The clinical medication of anti-tumor drugs is generally reasonable, but it still needs to be further improved. When necessary, therapeutic drug monitoring (TDM) should be carried out. At the same time, the attention should be paid to adverse drug reactions and efficacy, and as well as minimizing the occurrence of adverse drug reactions, so as to ensure the safety, effectiveness, rationality and individualization of drug use.
  • Analysis on Clinical Medication of Etimicin Sulfate Injection before and after Special Evaluation
    FAN Yun-ting, WANG Wan-xia, GONG Zhang-jun, NI Ji
    2020, 17(5): 650-655. https://doi.org/10.13493/j.issn.1672-7878.2020.05-007
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    Objective: To analyze the clinical medication of etimicin sulfate injection in our hospital, and to provide reference for promoting clinical rational drug use. Methods: Data of doctor's orders including etimicin sulfate from January to June 2017 (the group before special comment) and from January to June 2018 (the group after special comment) in the out-patient and emergency department were extracted, comparing DDDs values of etimicin sulfate before and after special comment, unreasonable medication and difference of ADR incidence rates. Results: After the special review and intervention of etimicin sulfate injection, the DDDs value, the proportion of unreasonable use of drugs and the incidence of ADRs in the post-review group were all lower than those in the pre-review group (P<0.05). The DDDs values of out-patient and emergency prescriptions and resident orders of etimicin in the review group decreased by 23.02% and 13.09%, the proportion of unreasonable medication decreased by 28.30% and 40.20%, and the incidence of ADRs decreased by 80.00% and 70.83%, respectively. Conclusion: Through the special comment and intervention of clinical pharmacists on etimicin sulfate injection, the clinical medication of etimicin sulfate injection in hospitals was standardized, and the medication safety of patients was ensured.
  • Analysis on Detection and Resistance of Non-tuberculosis Mycobacterium in TB Positive Patients in Suzhou Region during 2015 to 2018*1
    QIAN Yu-di, SONG Hua-feng, ZHAO Jing, XUE Jing, XU Ping
    2020, 17(5): 656-658. https://doi.org/10.13493/j.issn.1672-7878.2020.05-008
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    Objective: To investigate the detection and drug resistance of non-tuberculous Mycobacterium (NTM) in tuberculous (TB) positive patients in Suzhou area, and to provide reference for clinical drug use. Methods: Data of 9 359 patients with positive Mycobacterium tuberculosis （MTB） culture from January 2015 to December 2018 were collected, and the results of mycobacterium tuberculosis culture and drug sensitivity identified by culture medium using para-nitrobenzoic acid (PNB) were calculated to analyze the detection of MTB and its resistance to different anti-TB drugs. Results: Among the 9 359 positive patients, 9 359 strains of MTB were isolated, in which 8 142 strains of MTB and 1 217 strains of NTM accounted for 87.00% and 13.00%, respectively. The NTM detection rate was 12.85%, 10.59%, 13.85% and 14.09% from 2015 to 2018, showing small fluctuations. In 1 217 NTM patients, there were first-line drug sensitivity results, and the drug resistance rates were isoniazid (INH, 95.15%), streptomycin (SM, 88.66%), rifampicin (RFP, 66.64%) and ethambutol (EMB, 26.54%) respectively. In the 1 217 patients, 524 had second-line drug sensitivity results, and the drug resistance rates were para-aminosalicylate sodium (PAS, 97.71%), amikacin (AK, 81.87 %), levofloxacin (LVF, 71.56 %) and 2-ethylthioisonicotinamide (TH, 16.22 %). The resistance rate of NTM to SM decreased slowly with time. Conclusion: The detection rate of NTM in Suzhou region is lower than the results of the 5th national epidemiological survey of tuberculosis, and the drug resistance rate of NTM is higher, so effective prevention and control measures still need to be taken to ensure the effectiveness of drug use in patients.
  • Influence of PDCA Circular Management on Rational Usage of Antibiotics after Forbidding Out-patients Infusion in Community Children
    LI Li-shuang, FANG Wei-jie, Fang Zhen-sheng
    2020, 17(5): 659-661. https://doi.org/10.13493/j.issn.1672-7878.2020.05-009
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    Objective: To explore the influence of PDCA circular management on rational usage of anti-biotics after forbidding out-patients infusion in community children. Methods: Data of 110 cases of antimicrobial drugs prescribed in pediatric outpatient clinics from January 2019 to June 2019 were selected and divided into the pre-management group (n=52, before PDCA) and the post-management group (n=58, after PDCA) before and after PDCA cycle. The rational usage of antibiotics and their clinical efficacy before and after administration were analyzed, as well as the reasons for unreasonable use of antibiotics were also analyzed. Results: There was no statistically significant difference in the incidence of combined or single use of antimicrobial agents in the children group after PDCA administration compared with the group before management (P>0.05). The incidence rate of unreasonable drug use reasons (improper drug selection, unreasonable drug use method, unreasonable drug delivery time, irregular doctor prescription, etc.) was significantly lower than that of the pre-management group (P<0.05). The qualified rate of medication in the control group was significantly higher than that in the control group (P<0.05). Conclusion: PDCA circular management method was applied in the administration of antimicrobial drugs in children's outpatient clinics in the community, which effectively improved the rational utilization rate of antimicrobial drugs ensuring the efficacy and safety of drug use in children.
  • Pareto Chart Analysis on 43 200 Prescriptions of Outpatient and Emergency and Reasons for Unreasonable Medication
    ZHANG Gui-fen, YIN Wei-qing, WEI Ju-hong, TANG Hui, TANG Chen, LU Min, ZHU Ai-guo
    2020, 17(5): 662-667. https://doi.org/10.13493/j.issn.1672-7878.2020.05-010
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    Objective: To analyze the current situation of outpatient, emergency medication prescription and the reason of unreasonable medication, and its management countermeasures. Methods: 43 200 prescription of outpatient and emergency were selected from September 2018 to November 2019. According to the requirements of "Drug Instructions"and relevant laws and regulations, the rationality of drug usage were commented and analyzed, Pareto chart was used to analyze the causes of unreasonable prescription, and the main, secondary and general factors causing unreasonable prescription and the management countermeasures were found. Results: Among the 43 200 prescriptions, 2 054 were unreasonable, and the irrationality rate was 4.75%. Among the unreasonable prescriptions, 2 235 cases were found to be unreasonable. Unreasonable main factors was that they did not write clinical diagnosis or clinical diagnosis was not perfect (626 cases, accounted for 28.01%), the combination of drugs was not unsuited (340 cases, accounted for 15.21%), the usage and dosage were vague (276 cases, accounted for 12.35%), one prescription included more than 5 kinds of drugs (190 cases, accounted for 8.50%), the prescription including antimicrobial agents was not in accordance with guidelines for clinical application of antimicrobial agents(185 cases, accounted for 8.28%), etc.. The secondary factors of unreasonable prescription were inappropriate indications (124 cases, accounted for 5.55%), irregular signature and seal of doctors or inconsistent with retention samples (118 cases, accounted for 5.28%).The general factors of unreasonable prescription were improper usage and dosage (99 cases, accounted for 4.43%). Conclusion: The hospital should formulate effective management measures according to unreasonable prescription types, strengthen administrative intervention and prescription comment, and standardize prescription medication behavior, so as to promote clinical rational medication and ensure medical safety.
  • Evaluation and Analysis in Rationality of Antibiotics for Perioperative Prevention of 1 126 Patients of Type I Incision
    YU Jia, LUO Mei-feng
    2020, 17(5): 671-675. https://doi.org/10.13493/j.issn.1672-7878.2020.05-012
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    Objective: To evaluate and analyze the rationality of prophylactic medication of antibiotics in perioperative period for patients with type I incision surgery in hospitals, so as to provide reference for the prophylactic use of antibiotics in perioperative period. Methods: The clinical data of 1 126 patients with type I incision surgery admitted to the hospital from April to June 2019 were extracted to analyze the rationality of prophylactic use of antibiotics during perioperative period. Results: Among the 1 126 patients with type I incision surgery, the proportion of perioperative prophylactic use of antimicrobial agents in 302 patients accounted for 26.82%. The third generation cephalosporin was the main antibacterial agents for the prevention of clean surgery. In 302 cases, the unreasonable timing of prophylactic medication for clean surgery was mainly manifested in 19 cases (6.30%) that were greater than or equal to 1 hour before surgery, and 6 cases (1.99%) who did not use before surgery. The duration of prophylactic medication was longer than 24 hours, accounting for 36.75% of the 111 cases. Only 11.59% of the patients were rational in preventive drug use. The types of unreasonable drug use mainly include inappropriate drug selection, incorrect timing of drug administration, inappropriate drug requisition without indication and inappropriate course of treatment. Conclusion: The perioperative preventive medication for type I incision surgery in our hospital still has unreasonable phenomena in the selection of drugs and the course of administration. It should be further standardized.
  • Analysis on Detection Results of Food Contamination Bacteria in a Municipal Jurisdiction in 2019
    LI Feng-tao
    2020, 17(5): 703-706. https://doi.org/10.13493/j.issn.1672-7878.2020.05-022
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    Objective: To understand the bacterial contamination of food sold in municipal jurisdiction of Zhumadian, and to improve the ability of foodborne disease detection and risk assessment of urban food safety. Methods: According to the "National Foodborne Pathogens Detection Manual 2010 edition" issued by the Ministry of Public Health and GB/t4789-2003 and "the Food Contamination Detection Manual of Zhumadian" standards, the bacterial contamination was detected in 350 food samples in 2019. Results: 350 food samples in municipal jurisdiction of Zhumadian in 2019 were tested for indicator bacteria and pathogenic bacteria; 29 samples were found unqualified, the unqualified rate was 14.5%; 50 samples were positive for pathogenic bacteria, the unqualified rate was 14.29%; 4 main foodborne pathogenic bacteria were detected, including Salmonella, Listeria monocytogenes, Staphylococcus aureus and vibrio parahemolyticus; 50 samples of pathogenic bacteria were unqualified, the unqualified rate was 14.29%. Conclusion: The food sold in municipal jurisdiction of Zhumadian have bacterial pollution, and the pollution of foodborne pathogens is relatively serious. There is a certain potential risk of food safety, which needs to be paid attention by the relevant departments and strengthen the management of food safety.
  • Clinical Pharmacists Participating Pharmaceutical Care of Anti-fungal Medication of 1 AIDS Patient with Cryptococcus Neoformans
    WANG Lin-wen, CHEN Wen-ying, LAO Hai-yan
    2020, 17(5): 713-715. https://doi.org/10.13493/j.issn.1672-7878.2020.05-025
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    Objective: To study the pharmaceutical care methods of antifungal medication by clinical pharmacists in patients with Cryptococcal multi-site infection with AIDS. Methods: The clinical pharmacist participated in the drug treatment process of a case of Cryptococcus neoformans multi-site infection complicated with AIDS, and provided pharmaceutical care from the aspects of assisting doctors to formulate antifungal treatment plan, pharmaceutical care, adverse reaction management, etc.. Results: After the clinical pharmacist participated in the process of drug medication, the patient's condition was improved. Conclusion: Clinical pharmacists provided advice for doctors to use drugs reasonably and safely, provided pharmaceutical care for patients,and achieved better therapeutic effects.
  • Therapeutic Drug Monitoring in a Antibiotic Encepha-lopathy Patient induced by Ceftazidime Involved by Clinical Pharmacists
    YE Chao, XIE Jian-yong, HU Ying, WANG Zhao-hui
    2020, 17(5): 716-719. https://doi.org/10.13493/j.issn.1672-7878.2020.05-026
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    Objective: To explore the role of therapeutic drug monitoring(TDM) in the diagnosis and treatment of antibiotic encephalopathy patients induced by ceftazidime involved by clinical pharmacists. Methods: The causes and mechanisms of antibiotic encephalopathy induced by ceftazidime were analyzed by clinical pharmacists, and the relationship between the improvement of symptoms and the change of blood drug concentration was evaluated by analyzing the blood drug concentration of patients before and after TDM dialysis. The cause of antibiotic encephalopathy induced by ceftazidime in an elderly patient with renal failure was evaluated. Results: The TDM is effective in clinical diagnosis and treatment of antibiotic encephalopathy caused by ceftazidime. Conclusion: Therapeutic drug concentration monitoring and treatment of antibiotic encephalopathy is clinically operability and worthy of popularization and application. It is more important to prevent the occurrence of antibiotic encephalopathy through TDM.
  • Analysis on Related Factors in 512 Cases of Reported Adverse Drug Reactions in a Grade ⅢA Hospital
    QIU Xiao-ting, CHEN Yao-zhe, SONG Xing-dong
    2020, 17(5): 720-724. https://doi.org/10.13493/j.issn.1672-7878.2020.05-027
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    Objective: To analyze the characteristics and rules of adverse drug reactions (ADR) in 2018, and to provide references for rational use of drugs in clinic. Methods: 512 cases of ADRs reported to the Guangdong ADR Monitoring System collected from January 1 to December 31, 2018 were selected to analyze the factors related to the occurrence of ADRs. Results: In the 512 cases of ADRs, the male patient 238 (46.48%) and female patients 274 (53.52%) were involved. The highest age of patients with ADRs was between 61 and 70 years old (111 cases, 21.68%). The route of administration involved 622 cases, in which 452 cases (72.67%) were caused by intravenous drip administration. Among the 622 patients with ADRs involving drugs, 204 patients with ADRs induced by antimicrobial drugs accounted for 32.80%.There were 1 001 cases of ADRs involving organs/system, mainly 292 cases of skin, appendages and organs, accounting for 29.17%. the rash and pruritus were the most typical symptoms. Conclusion: The occurrence of ADRs is correlated with the patient's age, drug route, drug type and other factors. Clinical monitoring of ADRs should focus on the above influencing factors, and carry out individualized drug administration in combination with the patient's symptoms, so as to improve the level of clinical rational drug use and to ensure the safety of drug use.
  • Efficacy of Kanglao Granules Combined with Anti-TB Drugs in Patients with Non-TB Mycobacterial Lungs Disease and Its Influence on T cell*1
    SHI Cui-lin, YU Xin, SHEN Jie, YE Zhi-jian, WU Mei-ying
    2020, 17(5): 730-733. https://doi.org/10.13493/j.issn.1672-7878.2020.05-030
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    Objective: To explore the clinical efficacy of Kanglao granules assisted by anti-tuberculosis drugs on non-tuberculous Mycobacterial（NTM） lungs disease and its improvement on T cell subsets. Methods: Data of 70 patients with NTM lung disease diagnosed and treated from January to December 2017 were selected and divided into treatment group and control group according to different treatment and medication, with 35 cases in each group. The patients in the control group were treated with antituberculous Mycobacteria, and the patients in the treatment group were treated with the traditional Chinese medicine （TCM） Kanglao granules on the basis of the control group. The clinical effects (Mycobacterial negative rate, CT imaging improvement rate), clinical symptom scores, and changes of T cell subsets of the two groups of patients before and after treatment were observed. Results: The scores of TCM symptoms (night sweat, appetite) in the treatment group were lower than those in the control group (P<0.05). After treatment, the CD4 in the two groups was significantly higher than before treatment (P<0.05), and the CD4 value in the treatment group was significantly higher than that in the control group (P<0.001). But CD8, CD4/CD25 regulatory T cell% were not statistically significant between the two groups before and after treatment (P>0.05). Conclusion: Kanglao granules were used to assist antituberculosis drugs in patients with NTM tuberculosis, which effectively improved CD4 level, and the mechanism may be related to the regulation of CD4 T cell level.
  • Efficacy of Rabies Vaccine Combined with HRIG on Prevention of Rabies in Animal Bite Patients and Its Influence on Antibody Production
    LI Xue-mei
    2020, 17(5): 734-737. https://doi.org/10.13493/j.issn.1672-7878.2020.05-031
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    Objective: To explore the efficacy of rabies vaccine combined with human rabies immunoglobulin (HRIG) on the prevention of rabies in animal bite patients and its influence on antibody production. Methods: Data of 200 patients with animal bite exposure treated from July to October 2019 were selected. Based on the different prophylactic drugs, patients were divided into two groups, the rabies vaccination group (n=100, only with the inoculation of rabies vaccine) and the combined use group (n=100, rabies vaccine and HRIG combined use). The difference between the positive rate of anti-rabies antibody and the incidence of adverse drug reactions were compared between the two groups. Results: After 7 days of administration, the positive rate of rabies antibody in the combined treatment group was better than that in the rabies vaccination group (P<0.05). After 14 days of treatment, there were no statistically significant difference in the positive rate of rabies antibody between the two groups (P>0.05), and there were no statistically significant difference in the incidence of adverse drug reactions (P>0.05). Conclusion: Rabies vaccine combined with HRIG has better clinical efficacy in preventing rabies in patients exposed to animal bite. The human body can effectively produce rabies antibody in a short time, and the safety is high.
  • Clinical Efficacy of Polylactate-gentamicin Pellets in Patients with Bone Infection and Its Influence on Symptom Improvement
    ZHONG En-chun
    2020, 17(5): 740-742. https://doi.org/10.13493/j.issn.1672-7878.2020.05-033
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    Objective: To investigate the clinical efficacy of polylactate-gentamicin pellets in patients with bone infection and its influence on symptom improvement. Methods: Data of 60 patients with bone infection admitted in hospital from May 2016 to May 2019 were selected and divided into 30 patients in the control group and 30 patients in the observation group according to different treatment methods. Patients in the control group were given gentamicin bead chain treatment, and patients in the observation group were given polylactate-gentamicin bead local treatment. The difference of the total effective rate, recurrence rate and clinical symptom recurrence time were compared between the two groups.Results: The total effective rate of treatment in the observation group was higher than that in the control group (P< 0.05), the postoperative recurrence rate was lower than that in the control group (P<0.05), and the VAS score of clinical symptoms was significantly lower than that in the control group (P<0.05). Conclusion: The local treatment of bone infection with polylactate-gentamicin pellet has obvious curative effect, effectively improves the clinical efficacy, promotes the wound healing, and the recurrence rate is lower.