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  • 2020 Volume 17 Issue 10
    Published: 25 October 2020
      
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  • Research Advances on pharmacological Action of Matrine and Oxymatrine in Patients with Urinary Tumors
    ZHANG Ming-fa, SHEN Ya-qin
    2020, 17(10): 1399-1404. https://doi.org/10.13493/j.issn.1672-7878.2020.10-001
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    Matrine has the effects in inhibiting growth of human renal carcinoma ACHN cell transplantation in nude mice, and it also has the effect of the prophylaxis and treatment of rat bladder cancer induced by BBN. Matrine inhibits proliferation and induces apoptosis in association with dosage on human renal carcinoma ACHN cells, GRX-1 cells, 7860 cells, SK-NEP-1 cells, and bladder cancer T24 cells, T24/ADM cells, BIU-87 cells, BIU-87/ADM cells, EJ cells, and prostate cancer PC-3 cells, PC-3M cells, LNCaP cells, DU-145 cells. Matrine enhances the effects of cisplatin against SK-NEP-1 cells and adriamycin against drug-resistant T24/ADM cells and BIU-87/ADM cells. Oxymatrine inhibits proliferation in association with dosage on 7860 cells and T24 cells, PC-3 cells. In this paper,The data of the pharmacological action of matrine and oxymatrine on urinary system tumors have been reviewed, and the research progress has been analyzed, and matrine and oxymatrine can also be recommended for the treatment of COVID-19.
  • Experimental Study on Pharmacological Mechanism of Anemoside B4 in Ulcerative Colitis Induced by Acetic Acid in Rats*1
    ZHANG Yong, SHEN Wen-hua, ZHA Zheng-xia, HE Luan, LIU Yan-li, XU Qiong-ming
    2020, 17(10): 1405-1410. https://doi.org/10.13493/j.issn.1672-7878.2020.10-002
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    Objective: To explorer the effect of anemoside B4, the index component of Pulsatilla chinensis (Bge.), on ulcerative colitis in rats and its influence on histopathological changes, modeling of ulcerative colitis in rats induced by acetic acid. Methods: All animals were divided into five groups (n=10 per group): normal group, model group, anemoside B4 group (5 mg/kg), anemoside B4 group (10 mg/kg), and mesalazine group (200 mg/kg). Experimental ulcerative colitis was induced through colitis perfusion of 8% acetic acid solution after the rats were anesthetized. After 24 hours, anemosied B4 was injected twice per day continuously for 7 days, disease activity index (DAI) and weight of rats were measured every day. On the 7th day, the blood sample was obtained for biochemical detection, and weight of colon was measured and obtained for pathological examination. Western blotting was used to measure the level of the apoptosis proteins in colon and their effects on histopathological changes in each group of rats. Results: Compared with normal control group, acetic acid decreased the weight of rats and increased DAI scores and, index of weight-length of colon. Anemoside B4 could increase weight of rats induced by acetic acid and decreased index of weight-length of colon and DAI scores induced by acetic acid. Observing the histological feature of colon sections using H & E staining, the renal cortex of rats revealed the structures of intestinal mucosa were damaged with great inflammatory cell infiltration and increased apoptosis. While anemoside B4 significantly reduced inflammation and repaired the colon structure; inhibited cell apoptosis and inflammatory infiltration. Western blotting experiment results showed that expression of p53, cleaved caspase 3 and Bax were increased and Bcl-2 decreased. However, anemoside B4 decreased the level of p53, cleaved caspase 3 and Bax, while it increased Bcl-2 levels. ELISA experiment showed that compared with the model group, anemoside B4 could inhibit the release of inflammatory factors such as IL-6 and TNF-α. Conclusion: The effect of anemoside B4 on ulcerative colitis in rats was significant, and its mechanism might be related to anti-inflammatory and inhibition of apoptosis.
  • Study on Prevention and Treatment by using Guizhi Fuling Pills in Liver Fibrosis of Rats and Its Influence on Histopathological Morphology
    LI Xiao-hong, YE Jun, WANG Pei
    2020, 17(10): 1411-1416. https://doi.org/10.13493/j.issn.1672-7878.2020.10-003
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    Objective: To explore the prevention and treatment by using Guizhi Fuling pills on liver fibrosis of rats, and to study its influence on histopathological morphology and the possible mechanism of action. Methods: 88 rats were randomLy divided into normal group (8 rats), model group (20 rats), GUI pregroup (20 rats), GUI treatgroup (20 rats) and Qiu treatgroup (20 rats). Normal group rats were given normal saline to filling the stomach, groups building 6 weeks later, the rats were given colchicine (Qiu treatgroup), normal saline group (model group), GUI pregroup by Guizhi Fuling pills (GUI treatgroup) in rats after treatment of 4 weeks, 10 weeks left hepatic lobe in the same place with the blade cut in liver tissue, used it for HE and Masson staining to observe the changes in the form of liver tissue pathology. The expression levels of MMP-9, TIMP-1 and TGF-β1 were detected by immunohistochemistry. Results: In the normal group, the morphology of liver cells was normal, and the liver fibrosis was not observed. In the model group, the liver cells were denaturated and arranged in disorder, showing different degrees of changes in liver fibrosis; the rats of model group are the most obvious. The liver cell degeneration of rats was treated with Guizhi Fuling pills and colchicine was lighter than that of the model group .Compared with the treatment groups, the cell of preventive treatment group of Guizhi Fuling pills degeneration were not obvious, liver cell arrangement was regular, and liver fibrosis was mild hyperplasia. Immunohistochemical results showed that the positive expression of TIMP-1 and TGF-β1 in the model group were more than that in the normal group, with a significant difference (P<0.01). Compared with the model group, the positive expressions of TIMP-1and TGF-β1 in the treatment group were less (P<0.05 or P<0.01). Compared with Guizhi Fuling pills treatment group and colchicine treatment group, the positive expression of timp-1 TGF-β1 in Guizhi Fuling pills preventive treatment group was significantly reduced (P<0.01). There was no significant difference between Guizhi Fuling pills treatment group and colchicine treatment group (P>0.05). Compared with the normal group, the expression of MMP-9 protein in the model group was significantly increased, and the difference was significant (P<0.001). Compared with the model group, the positive expressions of MMP-9 in the treatment group were less (P<0.05 or P<0.01).Compared with Guizhi Fuling pills treatment group and colchicine treatment group, the positive expression of MMP-9 in Guizhi Fuling pills preventive treatment group was significantly reduced (P<0.05 or P<0.01). There was no significant difference between Guizhi Fuling pills treatment group and colchicine treatment group (P>0.05). Conclusion: Guizhi Fuling pills can reduce the degree of liver fibrosis, and the effect of prevention is more obvious. Its inhibitory effect on liver fibrosis was related to the down-regulation of positive expression of TIMP-1and TGF-β1.
  • Practice and Experience of Clinical Pharmacists Participating in Comprehensive Evaluation of Elderly Patients and Medication Mode
    LIN Zhen, LI Yang, SHI Tao, Ou-yang Shan-dan
    2020, 17(10): 1420-1423. https://doi.org/10.13493/j.issn.1672-7878.2020.10-005
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    Objective: To explore the effectiveness and experience of clinical pharmacists participating in the comprehensive evaluation and medication management for elderly patients. Methods: The data of 34 elderly patients with multiple drugs admitted from February 2017 to January 2018 using the general comprehensive assessment model were selected as the pre-intervention group, and the data of 34 elderly patients with multiple drugs admitted from February 2018 to January 2019 using the clinical pharmacist participating in the comprehensive assessment and medication management mode were selected as the post-intervention group. The changes in Barthel index of daily living ability, cognition, and fall risk scores before and after treatment were compared between the two groups, as well as the differences in drug efficacy, adverse reaction rate and reasonable drug treatment rate before and after treatment. Results: After intervention, the compliance rate of patients in the group was significantly higher than those in the group before intervention (P<0.05), the efficacy and rationality rate of medication were significantly higher than that in the group before intervention (P<0.05), and the incidence of adverse reactions was lower than that in the group before intervention (P<0.05). The scores of Barthel index and cognition of patients in the post-intervention group were significantly higher than those in the pre-intervention group (P<0.05), and the scores of fall risk were significantly lower than those in the pre-intervention group (P<0.05). Conclusion: The participation of clinical pharmacists in geriatric comprehensive assessment and medication management significantly improved the rationality and compliance of medication, and ensured the effectiveness and safety of medication.
  • Analysis in Distribution Characteristics and Drug Resistance of Multi-drug-resistant Acinetobacter Baumannii in a Hospital from 2015 to 2019
    WEI Yong-zi, CHEN Mao-wei, ZHANG Chun-lan, XU Xian-li, LAO Xiao-jie
    2020, 17(10): 1424-1426. https://doi.org/10.13493/j.issn.1672-7878.2020.10-006
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    Objective: To analyze the distribution characteristics and drug resistance of multi-drug resistant Acinetobacter baumannii in hospitalized patients, and to provide a reference for clinical diagnosis and treatment. Methods: Clinical data of 109 hospitalized patients with multidrug-resistant Acinetobacter baumannii infection were collected from January 2015 to September 2019. The clinical data of Acinetobacter baumannii isolated from various clinical specimens of its bacterial culture were counted, and the department distribution of multidrug-resistant Acinetobacter baumannii, the source of each specimen, and the drug sensitivity test results of non-fermentative bacteria of multidrug-resistant Acinetobacter baumannii were analyzed. Results: Among 109 patients with multidrug-resistant Acinetobacter baumannii infection, most patients were admitted to intensive care unit (78 cases, 71.56%), and 59 cases (75.64%) were infected with ventilator-associated pneumonia. More than 50% Acinetobacter baumannii were resistant to most antibacterial drugs such as quinolones, the second and third generation cephalosporins, tetracycline and doxycycline. Conclusion: Patients with multidrug-resistant Acinetobacter baumannii infection were mainly concentrated in intensive care units, and the infection site was mainly ventilator-associated pneumonia, with a high drug resistance rate, which should be paid great attention clinically.
  • Analysis on Drug Utilization Index of Latamoxef Sodium of in Neonates in a Children's Hospital and Its Influence on Rational Medication
    ZHOU Li-fang, ZHANG Li, WANG Er-kuan, JIANG Yun
    2020, 17(10): 1427-1431. https://doi.org/10.13493/j.issn.1672-7878.2020.10-007
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    Objective: To explore the clinical application of latamoxef sodium for injection in neonates in a hospital, and to provide reference for optimizing the administration scheme and rational drug use of neonates. Methods: The data of 803 hospitalized newborns who received the drug on the 11th day of each month in 2018 were extracted by continuous multi-point cross-sectional method. The utilization index of sodium oxycefin for injection was calculated (for example, gender, age of newborn and combined use of drugs, usage and dosage, diagnosis, laboratory examination results, unreasonable use of drugs, etc.) to analyze the rationality medication of latamoxef sodium. Results: There were 803 hospitalized newborns (male-female ratio was 1.32:1, and male infants were more than female), but the difference was not statistically significant when compared with children drug utilization index (cDUI). With the increase of neonatal day age, cDUI increases.Among them, 774 cases (96.39%) were treated with single antibacterial drug, and 29 cases were treated with combination drug (including 26 cases with dual drug use and 3 cases with triple drug use). 5 cases were treated with q8h, 798 cases were treated with q12h, but none was treated with q24h.The dosage was 40~80 mg/(kg·d) in 541 cases, and the dosage was greater than 80 mg/ (kg·d) in 262 cases, with the highest dosage being 238.81 mg/(kg·d).Conclusion: The laboratory basis for treating neonates with latamoxef sodium for injection was insufficient. The cDUI analysis results showed that all cDUI were greater than 1.0 and the maximum was 3.25, which indicated that there was irrational use of latamoxef sodium in clinical neonates.
  • Influence of Pharmaceutical Intervention on Rationality of Prophylactic Medication in Patients with PDCI in Nephrology Department
    FAN Hong-chun, CHEN Rui-huan, WEI Ju-hong, GUI Lai, TANG Hui, TANG Ye-qiu
    2020, 17(10): 1432-1434. https://doi.org/10.13493/j.issn.1672-7878.2020.10-008
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    Objective: To compare the rationality of perioperative prophylactic medication of antibiotics in patients undergoing the peritoneal dialysis catheter insertion (PDCI) before and after pharmaceutical intervention, and to provide reference for the rational medication of antibiotics in patients undergoing invasive diagnosis and treatment. Methods: The clinical data of 59 patients with end-stage renal insufficiency who underwent peritoneal dialysis implantation from January to December 2016 (pro intervention group, n=29 cases) and from January to December 2018 (post intervention group, n=30 cases) were selected. According to the guiding principles for clinical application of antibiotics (2015 edition), the differences of basic information and medical situations as well as expenses between the two groups were analyzed and compared. To evaluate the effect of intervention on the prophylaxis medication in perioperative period and related infections. Results: The prophylactic use rate of antibiotics in post intervention group was significantly lower than that in the pre intervention group (63.33% vs 93.10%, P<0.05). The incidence of catheter-related complications and abnormal inflammatory indexes were also significantly lower than those before intervention (16.67% vs 48.26%, P<0.05).The average daily hospitalization expenses of patients (936.7 vs 964.2 RMB yuan/d), average daily drug cost (466.2 vs 503.0 RMB yuan/d) and average daily cost of antibiotics (21.4 vs 43.8 RMB yuan/d) was slightly lower than that of the pre intervention group, but there was no statistical significance (P>0.05). Conclusion: After pharmaceutical intervention, the prophylactic medication of antimicrobial drugs in patients undergoing the PDCI was significantly reduced.However, the risk of postoperative infection has no increase.
  • Rationality Evaluation of Prophylactic Antibiotics in Patients with Type I Incision Surgical S ystem in a Hospital
    WANG Ping, ZHANG Ru-jun, CHEN Li-bo, WU Wen-wen, YAN Jiang
    2020, 17(10): 1435-1440. https://doi.org/10.13493/j.issn.1672-7878.2020.10-009
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    Objective: To evaluate the rationality of prophylactic antibiotics in patients with type I incision surgery in a hospital surgical system. Methods: The medical records of 874 patients with type I incision surgery in 2019 were collected, and the basic information (name, sex, age and medical record number) of the patients with type I incision surgery, the name of the operation and the operation time,the name of the antimicrobial agents for prevention,and the frequency of use ,and timing of use,and time of use were counted. The rationality of DDDs and DUI values of drugs used were analyzed and evaluated. Results: Among the 874 patients with type I incision surgery, 714 used prophylactic antimicrobials, accouting for 81.69%(714/874),the medical records of preventive antimicrobial agents DUI greater than 1 were 113 cases,accouting for 12.93%(113/874), 45 patients with etimicin injection DUI Greater than 1 accounted for 5.15% (45/874), 232 patients with etimicin injection accounted for 26.54% (232/874), 227 patients with ceftezole accounted for 25.97% (227/874); In the prevention of the use of antimicrobial agents, only 16 cases accounted for 1.83% (16/874) between 30 min and 1 hour before surgery, while postoperative medication and medication before 1 to 24 h accounted for 47.14% and 19.22%. respectively. Conclusion: Hospital surgical system Ⅰ class incision to prevent the use of antimicrobial drugs in surgical patients is as high as 87.07%; clinical pharmacists and administrative departments should actively intervene in the Ⅰ incision surgery, for preventive usage of antibacterial agents and strengthen standardization training to promote rational clinical drug use.
  • Analysis on Application and Effectiveness in Prevention and Control of Nosocomial Infection in Catheterization Room based on FEMA Methods
    WANG Qian
    2020, 17(10): 1476-1478. https://doi.org/10.13493/j.issn.1672-7878.2020.10-021
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    Objective: To analyze the application and effectiveness in prevention and control of nosocomial infection in catheterization room based on failure mode and effect analysis, FMEA methods. Methods: The data of nosocomial infection in the catheterization room of the hospital from January to December 2018 were selected as post-FMEA implementation group, and the data of nosocomial infection in the catheterization room before the implementation of the FMEA from January to December 2017 were selected as the group before the implementation of the FMEA. The risk factors of nosocomial infection in catheterization room were evaluated by FMEA method, and the root cause analysis method (RCA) was used to analyze the cause, and the countermeasures were proposed. The effect of FMEA method on the prevention and control of nosocomial infection in catheterization room was compared. Results: Through analysis, it is found that the risk factors of failure mode include the following 3 aspects: non-conforming environment of the catheter chamber, improper occupational protection, and non-standard medical waste disposal. The scoring values of occupational exposure rate, hospital infection rate and risk level after FMEA implementation were all lower than those before FMEA implementation (P<0.05). Conclusion: The catheterization room implements the risk management of FMEA nosocomial infection, which could accurately find out the risk causes of nosocomial infection and take timely measures to effectively improve the predictability of risks and reduce the risk of nosocomial infection.
  • Analysis on Risk Factors of Acute Poisoning Patients with Carbon Mon-oxide Complicated with Pulmonary Infection and Its Countermeasures*1
    CHEN Juan, SHEN Li, LUO Xiao-chun, GONG Wen-jian, HUANG Dong-ju, XU Yue-ping, YU Jing-wu
    2020, 17(10): 1479-1483. https://doi.org/10.13493/j.issn.1672-7878.2020.10-022
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    Objective: To study the risk factors of acute poisoning patients with carbon monoxide (CO) complicated with pulmonary infection and its preventive measures. Methods: The data of 180 patients with acute CO poisoning admitted from November 2016 to December 2019 were selected, and the general clinical data and clinical examination indicators were counted. The patients were divided into the infected group and the uninfected group based on whether they were associated with pulmonary infection. The differences in general clinical data and clinical examination indexes between the two groups were compared, and the risk factors and prevention and treatment strategies for pulmonary infection in patients with acute CO poisoning were explored by multivariate Logistic regression analysis. Results: Among 180 patients of CO poisoning, 41 patients were complicated with pulmonary infection. 31 patients with pulmonary infection recovered or improved after treatment, and the total effective rate after treatment was 75.61%. Compared with the non-infected group, the average age of the infected group was older, the exposure time of CO was longer, there were delayed encephalopathy, underlying diseases, the abnormal proportion of cerebral globulin was increased, and the blood levels of CRP, LDH, Lac and FIB were increased at admission and correlated with pulmonary infection (All P<0.05).Blood LDH, CRP, abnormal globule and CO exposure time were independent risk factors for acute CO poisoning complicated with pulmonary infection (All P<0.05). Conclusion: Analysis of the risk factors and prevention methods of pulmonary infection in patients with acute CO poisoning is helpful to adopt effective measures to prevent the risk of pulmonary infection in patients with acute CO poisoning, so as to improve the prognosis and survival rate of patients.
  • Clinical Efficacy and Pharmacoeconomic Evaluation of 5 Kinds of Different Cephalosporins in Children Patients with Bronchopneumonia
    XING Qi-zhen, ZHOU Yong-zhen, HUANG Wei, ZENG Qiao-ping
    2020, 17(10): 1497-1500. https://doi.org/10.13493/j.issn.1672-7878.2020.10-027
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    Objectives: To evaluate the clinical efficacy and pharmacoeconomics of 5 kinds of different cephalosporins (cefazolin sodium for injection, cefotaxime sodium for injection, cefmeningol sodium for injection, cefthiamidine for injection and cefuroxime sodium for injection) in children patients with bronchopneumonia, so as to provide reference for the selection of best clinical drug varieties. Methods: The medical records of hospitalized children in 2018 were selected to screen out the age, gender, drug use, adverse drug reactions, clinical efficacy and medical costs of the patients in the medical records of antimicrobial use. The cost-effectiveness analysis method was used to evaluate the efficacy and cost of 5 kinds of different cephalosporins in the treatment of children patients with bronchopneumonia, and to find out the antibacterial drugs with the best therapeutic effect and the lowest cost. Results: The total effective rates of cefazolin sodium for injection, cefotaxime sodium for injection, cefmeningol sodium for injection, cefthiamidine for injection and cefuroxime sodium for injection were 90.24%, 88.75%, 90.91%, 87.50% and 89.33%, respectively. There was no significant difference in the total effective rate between the two groups by χ2 test (P>0.05). When basically consistent efficacy was achieved, cefazolin sodium pentahydrate had a low cost-effectiveness, while the other 4 kinds of antibacterial drugs had a relatively high cost-effectiveness. Conclusions: Compared with the other 4 kinds of cephalosporins, the cost-effectiveness of cefazolin sodium for injection in the treatment of bronchopneumonia in children is superior, so it should be given priority to treat children with bronchopneumonia by using cefazolin sodium for injection.
  • Pharmaceutical Care for Anti-infective medication in a Patient with Meningitis of Staphylococcus Haemolyticus and Pulmonary Infection*1
    CUI Pu-mei, LIANG Yong-mei, CHEN Chao
    2020, 17(10): 1501-1504. https://doi.org/10.13493/j.issn.1672-7878.2020.10-028
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    Objective: To analyze the process of pharmaceutical care and thoughts of clinical pharmacists involved in the clinical anti-infection medication of patients with hemolytic Staphylococcal meningitis and pulmonary infection. Methods: The clinical pharmacist participated in the formulation and treatment process of anti-infective medication for a patient with hemolytic Staphylococcal meningitis and pulmonary infection, and carried out pharmaceutical practice from the aspects of selection of anti-infective drugs, program adjustment and therapeutic drug monitoring（TDM). Results: During the treatment process, clinical pharmacists assisted physicians in formulating individualized anti-infection medication plan by analyzing the patient's condition and combining PK/PD of antibacterial drugs, so that the patient's pulmonary infection was effectively controlled. Conclusion: The clinical pharmacists helped the clinician in their professional knowledge of pharmacy to optimize the treatment plan and carry out pharmaceutical care, which promoted the rational use of antibacterial drugs clinically.
  • Pharmaceutical Care for Clinical Medication in a Patient with Pulmonary Nocardiosis of Normal Immune Function Host
    XU Geng-min, XU Zhe-sheng, LUO Jia-xin
    2020, 17(10): 1505-1510. https://doi.org/10.13493/j.issn.1672-7878.2020.10-029
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    Objective: To explore the role of clinical pharmacists in clinical medication for patients with pulmonary Nocardiosis of normal immune function. Methods: Clinical pharmacists participated in the consultation to analyze the clinical characteristics and diagnosis and treatment process of pulmonary Nocardia infection in normal immune hosts. Combined with the patient's condition and drug sensitivity test results, it was suggested to stop the treatment of ciprofloxacin and imipenem-cilastatin. The treatment regimen was adjusted to moxifloxacin combined with cotrimoxazole (changed to cotrimoxazole alone after 1 week), and the whole process of pharmaceutical care of anti-infection treatment and follow-up of patients after discharge, and real-time pharmaceutical care. Results: The physician took the advice of the clinical pharmacist and adjusted the medication regimen in a timely manner. The patient's condition was improved. After discharge, the patient was followed up and the CT examination showed improvement. Conclusion: Clinical pharmacists participated in the whole process of pharmaceutical care for patients with infectious diseases with long course of disease and prone to relapse, which promoted rational drug use and ensured the effectiveness and safety of patients' treatment.
  • Analysis on Application and Effectiveness of Improving ABC Classification in Drug Inventory Structure management in Out-patient Pharmacy*1
    TAN De-fei, HU Xu-mei, BEI Shi-fang, SUN Xin, WU Qian-hu
    2020, 17(10): 1519-1523. https://doi.org/10.13493/j.issn.1672-7878.2020.10-033
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    Objective: To analyze the application and its effectiveness of improving ABC classification in drug inventory structure management in out-patient pharmacy, and to provide reference for optimizing the structure of drug inventory in out-patient pharmacy of hospital. Methods: The data of drug inventory structure in out-patient pharmacy optimized by ABC classification management method were extracted, and the representative drug inventory data were analyzed to find out the existing reasons and put forward the solutions. Results: ABC classification management method combined with pharmacology classification method was adopted to optimize the management of drugs in outpatient pharmacy under scientific classification. The original concept of drug classification based on pharmacology and drug nature was improved to optimize the structure of drug inventory. Conclusion: The improved ABC classification management method has optimized the drug inventory structure of out-patient pharmacy. The quantity of drug inventory and unmarketable drugs expiring were reduced, and the turnover of drug inventory funds was promoted.
  • Application of PIVAS MATE Software in Central Pharmacy of a Hospital and Its analysis on Reasons for Lossing Drug and Its Improvement*1
    SHI Xin, WANG Yong, ZHANG Shi-chao, ZHANG Jie, SHEN Guo-rong
    2020, 17(10): 1524-1527. https://doi.org/10.13493/j.issn.1672-7878.2020.10-034
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    Objective: To analyze the application of PIVAS Companion software (PIVAS MATE) in (pharmacy intravenous admixture service (PIVAS) and the reasons for lossing drug to optimize PIVAS MATE software design and reduce drug loss rate in central pharmacy. Methods: The loss amount and the lossing types of drugs reported in 2017, 2018 and 2019 were counted and sorted out. PIVAS MATE software was used to analyze the reasons and treatment methods of drug reported loss, so as to standardize and optimize the work flow and work system. Results: Compared with the manual loss reporting mode, the loss rate of drugs in the central pharmacy annual report in 2017 decreased from 0.097% to 0.044% in 2019 by using PIVAS MATE digitized electronic loss reporting software, with a decrease rate of 54.64%. Conclusion: By changing the traditional manual loss reporting mode and using PIVAS MATE software, the drug loss reporting rate can be greatly reduced and the resource cost loss caused by improper drug management can be reduced.