KANGGANRAN YAOXUE

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  • 2021 Volume 18 Issue 3
    Published: 25 March 2021
      
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  • Research Progress on Pharmacological Effects of Oxymatrine in Gastric Ulcer and Ulcerative Colitis
    ZHANG Ming-fa, SHEN Ya-qin
    2021, 18(3): 307-311. https://doi.org/10.13493/j.issn.1672-7878.2021.03-001
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  • Research Progress on Monomer Components in Traditional Chinese Medicine Against Candida Albicans*1
    CHEN Wan-xin, SHE Xiao-dong, LIU Wei-da
    2021, 18(3): 312-315. https://doi.org/10.13493/j.issn.1672-7878.2021.03-002
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    In recent years, with the irrational use of antibiotics and glucocorticoids, the incidence rate of fungal infection mainly caused by Candida albicans, whose resistance to conventional antifungal drugs is becoming more and more serious, is increasing. As anti-Candida albicans drugs, traditional Chinese medicine monomers have the characteristics of wide sources, low price and mild side effects. This paper reviews the literatures on the mechanisms of various common Chinese medicine monomers against Candida albicans, and analyzes the research progress, so as to provide a reference for exploring new clinical treatment ideas for patients with Candida albicans related infection.
  • Influence of Different Processing Time Exploring on Determination of Active Components in Sinapis Semen by UPLC*1
    LI Yi-xuan, SHENG Yi-liang, WU Yan, ZHANG Jing, ZHU Xing-yu, SHEN Jian-fei
    2021, 18(3): 316-320. https://doi.org/10.13493/j.issn.1672-7878.2021.03-003
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    Objective: To establish a method for simultaneous determination of active components (p-hydroxyphenylacetonitrile and sinapine thiocyanate) in fried Sinapis semen by UPLC, and to explore the influence of different processing time on the content of active components in fried white mustard seeds. Methods: Using UPLC method and Waters BEH C18 column (2.1 mm×100 mm, 1.7 μm), the gradient elution was carried out using acetonitrile-0.02 mol/L potassium dihydrogen phosphate solution as mobile phase. The detection wavelength was set at 222 nm, the flow rate was 0.3 mL/min, column temperature was 25 ℃, and sample size was 2 μL. The contents of p-hydroxyphenylacetonitrile and sinapine thiocyanate in the Sinapis semen were determined. Results: The linear range of p-hydroxyphenylacetonitrile and sinapine thiocyanate concentration was between 0.006 307 and 0.157 7 μg/mL (r²=1, n=6) and 0.01 472 and 0.368 0 μg/mL (r²=1, n=6), respectively. Conclusion: The established method for the determination of the content of the Sinapis semen is simple, accurate, repeatable and stable, as well as provides a basis for the quality control of the Sinapis semen decoction pieces.
  • Rational Analysis on Clinical Medication of Liver-protecting Drugs in 197 Tumor Patients with Liver Function Abnormalities*1
    ZHANG Xia-lan, SHEN Xi-kun, HUANG Yu-yu, WU Bin, SONG Ru-jun
    2021, 18(3): 321-325. https://doi.org/10.13493/j.issn.1672-7878.2021.03-004
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    Objective: To analyze the rationality of clinical adjuvant drugs for liver protection in tumor patients with abnormal liver function. Methods: Patients diagnosed as tumors admitted to the Department of Oncology of the hospital from January 2017 to December 2019 were selected. In addition, the clinical data of 197 hospitalized patients with liver function abnormalities caused by anti-tumor drugs were collected, and the gender, age, smoking and drinking history, basic liver diseases, biochemical indicators of liver function, clinical manifestations, use, cost and prognosis of liver-protecting drugs were calculated to analyze the rationality of the usage of liver-protecting drugs. Results: Among the 197 tumor patients diagnosed with abnormal liver function, 40.61% had a history of liver disease, 12.18% had a history of adverse drug reactions, and 32.49% had a history of alcohol consumption.Drug-induced liver injury and hepatobiliary tumors were the main causes of liver function injury.Levels of liver injury (Ⅰ or Ⅱ), use one kind of the prognosis of liver drug effect was the best; Ⅲ level or Ⅳ level, two or three kinds of drugs used in combination, protect liver prognostic effect was the best;The results showed that some of the liver-protecting drugs in doctors' orders were found to have repeated use of drugs, improper indications, improper combination of drugs, contraindications and unreasonable usage and dosage. Conclusion: Tumor patients with abnormal liver function caused by anti-tumor drugs, were reasonable selection of hepatoprotective drugs adjuvant therapy, and based on its condition and liver injury type of rational use of liver-protective drugs, in combined drug use no more than 3 kinds of drugs should be used.
  • Analysis in Drug Sensitivity of Staphylococcus Isolated from Blood of 193 Patients with Bloodstream Infection in a Hospital to Different Antimicrobial Agents
    ZHU Jing-le, FENG Ting-ting, ZHAO Wei-feng
    2021, 18(3): 326-329. https://doi.org/10.13493/j.issn.1672-7878.2021.03-005
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    Objective: To analyze the distribution and drug resistance of Staphylococcus in patients with bloodstream infection in different departments of the hospital, so as to provide a reference for clinical treatment of patients with bloodstream infection caused by Staphylococcus. Methods: A total of 193 strains of Staphylococcus bloodstream infection isolated from patients in different departments of the hospital from January to December 2019 were selected and their clinical data were analyzed. The distribution of Staphylococcus in patients of different departments with bloodstream infection and their drug resistance to antibiotics, as well as the isolation and drug resistance of MRSA and MSSA were analyzed. Results: Among 193 strains of Staphylococcus bloodstream infection, 41 strains of Staphylococcus aureus (21.24%) and 152 strains of Coagulase Negative Staphylococcus (78.76%); the drug resistance rates of Staphylococcus aureus to penicillin, erythromycin and clindamycin were 85.37% and 51.22%, respectively. The resistance rates of Coagulase negative Staphylococcus to penicillin was 98.68%, and to erythromycin was 84.87%. The resistance rates to ciprofloxacin, levofloxacin and moxifloxacin were higher than 70%. Most of Staphylococcus were sensitive to linezolid, but the detection rates and drug resistance rates of methicillin-resistant Staphylococcus aureus (MRSA) were high. Conclusion: The clinical multi drug resistance of Staphylococcus in hospital was severe, and the detection rates and drug resistance rates of MRSA were higher than MSSA. Clinical attention should be paid to it and drug regimen should be adjusted on time based on drug sensitivity results.
  • Analysis on Clinical Characteristics of Different Types of Neonates Infected with Streptococcus Agalactiae and Their Sensitivity to Drugs
    ZHOU Xiao-pan, HU Ning
    2021, 18(3): 330-334. https://doi.org/10.13493/j.issn.1672-7878.2021.03-006
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    Objective: To analyze the clinical characteristics of different types of Streptococcus agalactiae (SA) infected neonates and their sensitivity to drugs, so as to provide references for rational usage of antibiotics in clinical practice. Methods: The clinical data of 72 newborns diagnosed with SA infection admitted from January 2018 to December 2019 were selected, who were divided into 50 cases with early-onset infection and 22 cases with late-onset infection base on different infection periods. The clinical characteristics of the two groups of children and the influence of drug sensitivity test results on rational drug usage were analyzed. Results: The incidence of pneumonia and acute respiratory distress syndrome (ARDS) was higher than that of late onset (80.00% vs 54.50% and 28.00% vs 4.50%, P<0.05), while the incidence of sepsis and meningitis was lower than that of late onset (52.00% vs 77.30% and 18.00% vs 45.50%, P<0.05). The susceptibility test results showed that the susceptibility of SA strains to penicillin, linezolid, ampicillin and meropenem was 100.00% in both early and late onset groups. The sensitivity rates of SA strain to vancomycin, levofloxacin, cefuroxime and ceftriaxone in the early-onset group were 98.00%, 88.00%, 94.00% and 88.00%, respectively. The sensitivity rates of SA strain to vancomycin, levofloxacin, cefuroxime and ceftriaxone in the late-onset group were 95.50%, 81.80%, 90.90% and 81.80%, respectively. The drug resistance rates of SA strain to erythromycin and clindamycin were 90.00% and 82.00%, respectively, in the early-onset group, and 81.80% and 81.80%, respectively, in the late-onset group. Conclusion: Early-onset SA infection and late-onset SA infection had different clinical characteristics. Based on the results of SA drug sensitivity, antibiotics with high sensitivity rate (penicillin, vancomycin, ampicillin and meropenem) should be selected reasonably for treatment, and drugs with high drug resistance rate should be avoided.
  • Analysis on Characteristics of Pathogenic Bacteria Spectrum and Drug Sensitivity in Infected secretions of Incision in 164 Patients with Vertebral Body Surgery
    WANG Hong-sheng
    2021, 18(3): 335-338. https://doi.org/10.13493/j.issn.1672-7878.2021.03-007
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    Objective: To analyze the characteristics of pathogenic bacteria spectrum and drug sensitivity in infected secretions of incision in 164 patients who received vertebral body surgery. Methods: The clinical data of 164 patients with wound infection after vertebra surgery admitted to the hospital from March 2014 to May 2017 were selected to analyze the culture and isolation of pathogenic bacteria in the infected secretion from the incision and the drug sensitivity test results of the main Gram-negative bacteria and Gram-positive bacteria against different antibacterial drugs. Results: 184 strains of pathogenic bacteria were isolated from the secretions of 164 patients after surgery, in which the Gram-negative bacteria (73.37%) were mainly Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii, and the Gram-positive bacteria (26.63%) were mainly Staphylococcus aureus. The drug resistance rates of Staphylococcus aureus to vancomycin and penicillin in Gram-positive bacteria were as high as 100.00%, while the drug resistance rates of cefepime and cefoperazone were 58.33% and 62.50% respectively. The drug resistance rates of Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii to meropenem and imipenem were all higher than 90% in Gram-negative bacteria. Conclusion: The infective pathogens of postoperative incision infection in patients who received vertebral body surgery were mainly caused by Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii, and the infective pathogens showed almost no sensitivity to vancomycin, penicillin, meropenem and imipenem, and were completely drug-resistant. In order to ensure the effectiveness of anti-infection, sensitive antibiotics should be selected based on the drug resistance of pathogenic bacteria.
  • Comparison of Effectiveness of Clinical Pharmacists before and after Intervention on Reducing Intensity and Utilization Rate of Antimicrobial Agents in In-patients
    OU Zhong-shun, CHENG Ming-jian, ZHONG Tian-wen, FENG Wei-jie
    2021, 18(3): 339-342. https://doi.org/10.13493/j.issn.1672-7878.2021.03-008
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    Objective: To compare the effectiveness of clinical pharmacists' before and after intervention on reducing the intensity and utilization rate of antibacterial drugs in in-patients, so as to provide reference for promoting the rational use of antibacterial drugs in hospitals. Methods: The data of all indicators of antimicrobial use (intensity of use, utilization rate and antimicrobial agents for class I incision preventive medication) in the hospital from January to June 2019 were selected as the pre-intervention group. In addition, the antimicrobial drug use index data from July to December 2019 were selected as the post-intervention group. The intensity and utilization rate of antimicrobial agents were compared between the two groups, as well as the usage of antimicrobial agents for class I incision prevention. Results: The use intensity of prophylactic antibiotics decreased from 50.51 DDD/(100 persons·d) to 40.91 DDD/(100 persons·d) (P<0.05), the use rate decreased from 50.56% to 45.54% (P<0.05), and the proportion of prophylactic antibiotics for type I incision surgery decreased from 26.73% to 24.24%. Conclusion: After intervention, the evaluation index of antibacterial drug usage in in-patients was significantly improved, enhancing the level of rational drug use in hospitals, playing the professional role of clinical pharmacists, and also enhancing the awareness of clinicians on rational use of antibacterial drugs, finally ensuring the safety, effectiveness, economy and rationality of patients' drug use.
  • Exploration of Composition of Pathogenic Bacteria and Resistance to Antimicrobial Agents in Sputum of 120 Patients of Early Lung Cancer with Pulmonary Infection
    LI Yan-yan, WANG Hong-ke, GU Jian-fa, XING Guo-chen, YI Shan-yong
    2021, 18(3): 343-346. https://doi.org/10.13493/j.issn.1672-7878.2021.03-009
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    Objective: To explore the composition of pathogenic bacteria and resistance to antimicrobial agents in sputum of patients suffering from early lung cancer with pulmonary infection, and to provide scientific guidance for reasonable clinical anti-infection treatment. Methods: The medical records of 120 patients with early lung cancer and pulmonary infection admitted to the hospital from April 2016 to June 2020 were selected. The culture, isolation and drug sensitivity test results of pathogenic bacteria in sputum specimen of the lower respiratory tract of the patients were counted. The composition of pathogenic bacteria in sputum of specimen and the resistance characteristics of main pathogenic bacteria to various antibacterial drugs were analyzed. Results: In the sputum specimens of 120 patients, 156 strains of pathogenic bacteria were isolated, in which Gram-negative bacteria (56.41%) were the dominant bacteria, followed by Gram-positive bacteria (27.56%) and Fungi (16.03%). Among the main Gram-positive bacteria, Staphylococcus aureus had higher drug resistance rate to penicillin, Enterococcus faecalis had higher drug resistance rate to clindamycin, Coagulase-negative Staphylococcus had higher drug resistance rate to penicillin, clindamycin and gentamicin, all of which had lower drug resistance rate to vancomycin. Among the main Gram-negative bacteria, the drug resistance rate of Pseudomonas aeruginosa to ampicillin, ceftriaxone and cefazolin was higher, that of Klebsiella pneumoniae and Escherichia coli to ampicillin was higher, and that of imipenem was lower. Candida albicans has low resistance rate to antifungal drugs among main fungi. Conclusion: The gram-negative bacteria were the main pathogenic bacteria in patients with early lung cancer and pulmonary infection, and the drug resistance was serious and had multiple drug resistance. The results of the comprehensive drug sensitivity test showed that vancomycin or imipenem could be considered to be good for treatment, but the actual clinical medication should still be determined based on the individual situation of the patients, and the etiological examination and drug resistance monitoring should be strengthened to ensure the rational use of antibacterial drugs.
  • Analysis on Pathogens Culture and Current of Drug Resistance in Blood of 120 Patients Infected with Human Immunodeficiency Virus (HIV)
    XUE Xi-mei, XIAO Qing, WANG Yong-sheng
    2021, 18(3): 347-349. https://doi.org/10.13493/j.issn.1672-7878.2021.03-010
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    Objective: To analyze the distribution of pathogens in the blood of patients infected with human immunodeficiency virus (HIV), and to study the status of drug resistance. Methods: Medical records of 120 patients diagnosed with HIV infection from February 2017 to March 2020 were selected to analyze the pathogen culture and drug sensitivity test results of the samples submitted. Results: In the blood samples of 120 HIV infected patients, 25 strains of pathogenic bacteria were isolated. In the detection of 25 strains of pathogenic bacteria, the Fungus 10 strains (40.00%, 3 strains of Talaromyces marneffei, 7 strains of Cryptomyces neoformans), Gram positive coccus 8 strains Staphylococcus hominis (32.00%, 3 strains of Squirrels, 2 strains of Staphylococcus aureus, Staphylococcus epidermis Staphylococcus aureus strains and 1 strain of Staphylococcus Schleiferi), 5 strains (20.00%) were Gram positive bacillus and 2 strains of Gram-negative bacillus (8.00%). The mean alarm time for bacteria and fungi was (16.0±0.5) h and (53.0±3.2) h respectively. In the 25 positive strains, 3 strains (12.00%) were both positive, 14 strains (56.00%) were positive only by oxygen bottle culture, and 8 strains (32.00%) were positive only by anaerobic bottle culture.7 strains of Cryptococcus Neoformans were all sensitive to 3 kinds of antifungal drugs, including voriconazole, fluconazole and amphotericin B. Among the 8 strains of Gram-positive cocci (mainly Coagulase-negative Staphylococcus), 3 strains were methicillin-resistant Staphylococcus (37.50%). Among the antibiotics, linezolid, vancomycin and gentamicin were sensitive to Staphylococcus 100.00%, but resistant to clindamycin and erythromycin. Gentamicin and sulfamethoxazole were more sensitive to Nocardia asteroides. Conclusion: Fungal infection is the main pathogen of HIV infection, in which the infection rate of Cryptomyces neoformans is the highest. Clinically, drug treatment with high sensitivity rate should be selected based on its drug sensitivity results to prevent its transmission.
  • Analysis on Distribution and Drug Resistance of Infective Pathogens in 100 Elderly Patients with Severe Pneumonia in a Hospital
    LI Jie, YANG Ning-bo, YIN Xiao-jun, ZHANG Guo-xiu
    2021, 18(3): 350-353. https://doi.org/10.13493/j.issn.1672-7878.2021.03-011
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    Objective: To analyze the distribution and drug resistance of infective pathogens in elderly patients with severe pneumonia. Methods: The medical records of 100 elderly patients with severe pneumonia admitted to the hospital from July 2017 to July 2020 were selected, and the results of pathogen culture and drug sensitivity test were statistically analyzed to explore the distribution of pathogenic bacteria and the characteristics of resistance of main pathogenic bacteria to antibacterial drugs. Results: In the sputum samples of 100 patients, 89 strains of pathogenic bacteria were isolated, among which 59 strains of Gram-negative bacteria accounted for 66.29% (mainly Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae), 24 strains of Gram-positive bacteria accounted for 26.97% (mainly Staphylococcus haemolyticus and Streptococcus pneumoniae) and 6 strains of fungi accounted for 6.74%. The drug resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa to cefazolin and ampicillin were higher in Gram-negative bacteria, while the drug resistance rates of Klebsiella pneumoniae to ampicillin and cefotaxime were higher. The drug resistance rates of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae to ciprofloxacin, amikacin and imipenem were low. The drug resistance rates of Staphylococcus haemolyticus to piperacillin and Streptococcus pneumoniae to penicillin and gentamicin were higher in positive bacteria. The drug resistance rates of Staphylococcus haemolyticus and Streptococcus pneumoniae to cefazolin, imipenem and vancomycin were lower. Conclusion: Most of the elderly patients with severe pneumonia were infected with Gram-negative bacteria, followed by Gram-positive bacteria. Pathogenic strains in Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, hemolytic Staphylococcus aureus, Streptococcus pneumoniae infection is given priority to, and different pathogenic bacteria of various antibacterial drug resistance characteristics of each are not identical, should be combined with clinical rational use of antimicrobial drugs, drug sensitive test results and control infection, inhibit the disease progression.
  • Analysis on Related Factors in 38 Cases of Adverse Drug Reactions Induced by Levofloxacin Injection
    TANG Liu-xing, XIANG Zheng, SHI Ai-ming, PAN Jie
    2021, 18(3): 416-418. https://doi.org/10.13493/j.issn.1672-7878.2021.03-031
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    Objective: To analyze the causes and characteristics of adverse drug reactions (ADRs) induced by levofloxacin injection, and to provide reference for the safe use of quinolones. Methods: Data of 38 cases of adverse drug reactions of levofloxacin injection in the past 5 years were retrieved from CNKI, WANFANG and VPCS. The related factors of ADRs caused by levofloxacin injection (gender, age, cause of medication, dose, occurrence time of adverse reactions, its manifestations, etc.) were analyzed and investigated. Results: The adverse reactions of levofloxacin injection were reported in 37 papers, involving 38 academic patients. Among them, the middle-aged and elderly patients accounted for more than 65%, and 34% of the patients had ADRs within 1 hour after taking the drug, and the adverse reaction symptoms were mainly skin allergic reactions and damage to the central nervous system. Conclusion: The clinical medication should strictly follow the indications, usage and dosage of levofloxacin injection prescribed in the manual, and the occurrence of adverse reactions should be closely monitored within 60 min of the medication, so as to ensure the safety of the medication for patients.
  • Clinical Treatment and Pharmaceutical Care of Pseudomenbranous Colitis Induced by Antibacterial Agents in 1 Patient with Fungal Infection
    YANG Jing
    2021, 18(3): 422-424. https://doi.org/10.13493/j.issn.1672-7878.2021.03-033
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    Objective: To explore the role of multidisciplinary team (MDT) consultation and clinical pharmacists in treatment of infection-related diseases, clinical pharmacists conducted clinical treatment and pharmaceutical care of pseudomenbranous colitis caused by antifungal drugs in a patient with fungal infection. Methods: MDT consultation was carried out, and clinical pharmacists were involved in the formulation of safe and effective treatment plans for patients with pseudomenbranous colitis, and pharmaceutical care was given to the patient. Results and Conclusion: MDT consultation can timely adjust the treatment plan and the pharmaceutical care for patients was implemented to improve the safety and effectiveness of medication.
  • Pharmaceutical Care for Renal Function Injury Caused by Treatment of Vancomycin in a Patient with Infective Endocarditis
    WEI Hong-qun
    2021, 18(3): 425-427. https://doi.org/10.13493/j.issn.1672-7878.2021.03-034
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    Objective: To Explore the pharmaceutical care for renal function injury caused by treatment of vancomycin in a patient with infective endocarditis. Methods: Clinical pharmacists participated in the treatment of renal injury caused by vancomycin in 1 patient with infective endocarditis, and the adjustment of drug regimen based on the degree of renal injury and vancomycin blood concentration of the patient were proposed, and the pharmaceutical care of drug safety was implemented. Results and Conclusions: By utilizing their professional advantages, clinical pharmacists put forward individualized drug adjustment plans and carried out pharmaceutical care, so as to ensure the safety and effectiveness of drug treatment for patients and reduced the impact of adverse drug reactions on patients.
  • Influence of Zero Stock Management Based on Drug Group Purchasing Organization Mode on Hospital Drug Supply and Pharmacy Management
    WENG Shun-long, MO Guo-dong, HUANG Cai-yan, LU Zhi-jun
    2021, 18(3): 428-432. https://doi.org/10.13493/j.issn.1672-7878.2021.03-035
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    Objective: To explore the influence of zero stock management based on drug group purchasing organization mode (GOP) on hospital drug supply and pharmacy management, so as to provide a reference for rational drug purchase and pharmacy management in hospitals. Methods: The data of drug purchase and warehousing in hospital from October 2019 to March 2020 (after implementation) and the data of drug purchase and warehousing from April 2019 to September 2019 (before implementation) were extracted for statistics and analysis on the rate, timeliness and accuracy of drug distribution of different purchasing platforms in different time periods,as well as the changes in the amount of drug sales before and after the implementation of GPO. Results: After complementing GPO, the drug distribution rate was lower, the distribution accuracy was lower and the amount of drug sales was lower compared with that of before the complementation of GPO, while the average distribution time was longer. The rank of the same purchasing platforms according to the average distribution time from short to long was as follows: a city's GPO Platform (city platform for short), a Province's the Third-Party Drug Electronic Trading Platform (electronic trading platform for short) and Quanyaowang.com platform (yaowang platform for short). Except in November, the distribution accuracy of Yaowang Platform was lower than that of city platform. Conclusion: The differences of key distribution indexes among different purchasing platforms was very easy to affect the drug supply in hospitals and the drug management in pharmacies. For the drug procurement of different purchase platforms, pharmacies should reasonably plan countermeasures (expanding container stock, increasing pharmaceutical reserve in pharmacies, raising the purchase threshold, reducing frequency of purchase, increasing the purchase volume), so as to improve pharmacy management level and ensure an adequate drug supply in hospitals.
  • Application and Efficacy Evaluation of Quality Control Circle Activity in Shortening Waiting Time of Patients in Peak Period of Out-patients Pharmacy
    ZHENG Lu
    2021, 18(3): 433-438. https://doi.org/10.13493/j.issn.1672-7878.2021.03-036
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    Objective: To evaluate the application and efficacy of Quality Control Circle (QCC) activity in shortening the waiting time for the patient to get drugs in the peak period of out-patient pharmacy. Methods: The average waiting time of patients before the QCC activity (from December 1, 2019 to December 31, 2019) and after the QCC activity (from March 1, 2020 to June 30, 2020) were selected to compare the changes of waiting time before and after the QCC activity, and the indicator effects of tangible results of the activity were evaluated. Results: After QCC activity, the average waiting time of patients was shortened from 10.70 min to 5.10 min, the target achievement rate was 101.82%, and the improvement rate was 52.34%. The staff's ability to solve problems was improved, the spirit of team cooperation was enhanced, as well as the QCC technique and other intangible achievements were highlighted. Conclusion: The application of QCC management tool can effectively shorten the waiting time of patients in the peak period of out-patients pharmacy. At the same time, it also enhanced the ability of the pharmaceutical team to have cooperation spirit and solve problems.