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  • Research Progress on Clinical Medication of Anti-malarial in Artemisinin and Its Derivatives
    GU Wen-li
    2021, 18(4): 463-466. https://doi.org/10.13493/j.issn.1672-7878.2021.04-001
    Abstract ( 286 ) Download PDF ( 15 )   Knowledge map   Save
    Malaria is a parasitic disease leading to global spread and epidemic, which seriously threatens and endangers human health. Based on incomplete statistics, there are about 200 million cases of malaria patients caused by this parasite every year, and the number of death cases is nearly 440 000. It's universally acknowledged that the most effective way to treat malaria patients and reduce their clinical mortality rate is "early prevention, early diagnosis and effective treatment". Artemisinin is refined from Artemisia annua Linn, a traditional medicinal plant in China. Owing to its outstanding efficacy and application value in the treatment of malaria such as P. falciparum malaria and P. vivax malaria, artemisinin has become an important research object of medical researchers. It has experienced decades or even generations of research and achieved outstanding results. In this paper, the development of artemisinin and its derivatives, the antimalarial mechanism, metabolism of artemisinin and clinical treatment of artemisinin have been reviewed, and the research progress of artemisinin has been also analyzed.
  • Research Progress on Pharmacologic Effect of Matrine Against Gastrointestinal Tract Diseases
    ZHANG Ming-fa, SHEN Ya-qin
    2021, 18(4): 467-471. https://doi.org/10.13493/j.issn.1672-7878.2021.04-002
    Abstract ( 99 ) Download PDF ( 5 )   Knowledge map   Save
    Matrine has the effects to regulate gastrointestinal movement, and to inhibit colorectal propellant movement, and to protect on gastrointestinal mucosa. Matrine can prevent and treat diarrhea and colitis, including ulcerative colitis, and ulcer and chronic atrophic gastritis. Its mechanisms are related to antioxidation, anti-inflammation and immunoregulation. Matrine has the effects of anti-virus and pulmonoprotection too. The literatures of pharmacological effects of matrine on gastrointestinal diseases have been reviewed and their research progress has been analyzed.
  • Study on Compatible Stability of Chlorogenic Acid and Gardenoside in Solution of Reduning Injection Mixed with 3 Kinds of Common Infusion
    SONG Fa-xiang
    2021, 18(4): 472-474. https://doi.org/10.13493/j.issn.1672-7878.2021.04-003
    Abstract ( 75 ) Download PDF ( 7 )   Knowledge map   Save
    Objective: To study the compatible stability of chlorogenic acid and gardenoside in the solution of Reduning injection mixed with 3 common infusions. Methods: Reduning injection was mixed with 3 common infusions (5% glucose injection, 10% glucose injection and 0.9% sodium chloride injection), respectively. The pH changes of the solutions, as well as the content changes of the main components gardenoside and chlorogenic acid in the solution were investigated within 10 h. Results: The pH value of Reduning injection, 5% glucose injection and 0.9% sodium chloride injection had no significant change at 2, 4, 6, 8 and 10 h immediately after compatibility (0 h). The pH value of Reduning injection and 10% glucose injection had no significant change at 2 h, but at 4, 6, 8 and 10 h, the pH value of the solution increased significantly. When Reduning injection was mixed with 5% glucose injection and 0.9% sodium chloride injection, the relative contents of the main components (gardenoside and chlorogenic acid) had no significant changes at 2, 4, 6, 8 and 10 h. But Reduning injection with 10% glucose injection compatibility after compatibility of liquid in 4, 6, 8 and 10 h below the relative contents of chlorogenic acid. Reduning injection with 5% glucose injection and 0.9% sodium chloride injection compatibility of liquid, prompt Reduning injection with 10% glucose injection compatibility after compatibility of liquid in 10 h chlorogenic acid content lower than 95%, and compatibility with other 2 infusions after its content were over 95%. Conclusions: After the compatibility of Reduning injection and 10% glucose injection, the pH of the compatibility solution increased gradually with time, and the content of chlorogenic acid, the active component, decreased gradually. It should be used within 4 h after the compatibility.
  • Analysis on Causes of 669 Unreasonable Medication of Doctor's Orders in PIVAS in a Hospital and Its Countermeasures
    SU Hui, ZHANG Gui-fen, LU Min, ZOU Yin
    2021, 18(4): 475-482. https://doi.org/10.13493/j.issn.1672-7878.2021.04-004
    Abstract ( 67 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To analyze of the causes of 669 unreasonable medications of Doctor's Orders in Pharmacy Intravenous Admixture Services (PIVAS) in a hospital and its countermeasures and to provide reference for promoting rational drug use in clinic. Methods: A total of 2 492,981 medical orders in PIVAS prescription review records from January 2018 to October 2020 were collected to analyze the rationality of the medication of Doctor's Orders and the reasons for irrational drug usage. Results: In the 2 492 981 Doctor's Orders, 669 medical orders for unreasonable drug usage accounted for 0.268‰ of the Doctor's Orders for infusion deployment, and the unreasonable medical orders for antibacterial drugs accounted for 10.31% of the unreasonable medical orders.Emergency internal medicine, oncology (20 wards) and traditional Chinese medicine were the TOP 3 wards of unreasonable medical orders. The TOP 3 types of unreasonable drug use included unsuitable dosage of solvent, unsuitable type of solvent and unsuitable frequency of drug administration. The TOP 3 drugs categories were digestive system drugs, immunomodulator and hematological system drugs. There were many types of drugs involved in unreasonable medical orders, including anti-tumor drugs, antimicrobial drugs and digestive system drugs. The single variety drugs involved in unreasonable medical orders were lentinan, sodium carotene sulfonate and anisodamine hydrobromide. Clindamycin was ranked as the TOP 1 antibiotic in unreasonable advice. Conclusions: The Prescription checking pharmacists in PIVAS played an important role in ensuring the effectiveness and safety of patients' intravenous medication. Prescription checking intervention was adopted to ensure the safety of patients' intravenous medication.
  • Influence of Dynamic Monitoring based on Renal Function Indicators on Evaluation of Efficacy and Safety of Vancomycin in Elderly Patients with MRSA Pneumonia
    FENG Hui
    2021, 18(4): 483-487. https://doi.org/10.13493/j.issn.1672-7878.2021.04-005
    Abstract ( 78 ) Download PDF ( 5 )   Knowledge map   Save
    Objective: To explore the feasibility of dynamic monitoring based on renal function indicators for evaluating the efficacy and safety indicators of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia, and to provide reference for the feasibility evaluation of vancomycin in pharmaceutical care. Methods: Data of 118 elderly patients with MRSA pneumonia admitted to our hospital from March 2017 to February 2020 were selected. Based on different treatment methods, the patients were divided into conventional treatment group (n=56, conventional vancomycin was used) and intervention group (n=62）, that was, the dosage of vancomycin was adjusted base on the dynamic monitoring of endogenous creatinine clearance rate (CCR), serum creatinine (SCR) and urea nitrogen (BUN). The changes of measured values of CCR, SCR, BUN and the difference of serum valley concentration of vancomycin were compared between the two groups before and after treatment, and the correlation between the changes of measured values of CCR, SCR, BUN and serum valley concentration of vancomycin was analyzed, so as to explore the differences of clinical efficacy and incidence of adverse reactions between the two groups after treatment. Results: Two-way ANOVA showed that the serum valley concentrations of Scr, BUN and vancomycin in the intervention group were significantly lower than those in the conventional treatment group, but the CCR value was significantly higher than that in the conventional treatment group (P<0.05). Pearson correlation analysis showed that the serum valley concentration of vancomycin was negatively correlated with CCR (r=–0.473), but positively correlated with SCR (r=0.537) and BUN (r=0.619) (P<0.05). There was no statistical significance in the total effective rate and MRSA clearance rate of vancomycin treatment between the two groups (P>0.05), but the incidence of adverse reactions in the intervention group was significantly lower than that in the conventional treatment group (P<0.05). Conclusion: Dynamic monitoring of CCR, SCR and BUN values could reflect the therapeutic window range of vancomycin plasma drug valley concentration (10~20 mg/L), which had guiding significance for clinical prevention of renal function injury, clinical efficacy and safety.
  • Influence of Pharmaceutical Intervention on Clinical Pathway of Interventional Medication in Patients with Unstable Angina Pectoris
    PAN Qiao-na, HAN Qiang, WU Guang, ZHU Wan-qing
    2021, 18(4): 488-494. https://doi.org/10.13493/j.issn.1672-7878.2021.04-006
    Abstract ( 100 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To explore the application efficiency of clinical pharmacists in the medication of patients with unstable angina pectoris (UAP) based on the clinical pathway of unstable angina pectoris (2009 edition) embedded pharmaceutical care, and to provide reference for the formulation of UAP pharmaceutical care pathway. Methods: A total of 100 patients with UAP admitted to the cardiovascular department of the hospital from January to May 2020 were selected and divided into the pharmaceutical intervention group (n=50) and the conventional intervention group (n=50). The conventional intervention group received conventional monitoring and treatment, while the pharmaceutical intervention group received pharmaceutical monitoring pathway intervention on the basis of conventional monitoring and treatment. The efficiency of different intervention methods on the clinical pathway (length of stay, incidence of adverse reactions, improvement degree of biochemical indicators, disease outcome, etc.) were compared and analyzed between the two groups. Results: After different intervention, the average hospitalization time of patients in pharmaceutical intervention group was (6.66±1.86) d shorter than that in conventional intervention group (7.28±2.51) d (P<0.05), and the incidence of ADRs was lower than that in conventional intervention group (16.00% vs 42.00%, P<0.05). Through the clinical pathway of pharmaceutical care, combined with UAP treatment "Guide", "The expert consensus", Journal of clinical pathway, and related pharmaceutical professional knowledge, formulated the executable flow chart of the unstable angina pharmaceutical guardianship and unstable angina pharmaceutical care path form, standardizes the UAP patients with pharmaceutical care path. Conclusion: Through the pharmaceutical care of the clinical pathway of UAP patients, the incidence of ADRs during hospitalization was effectively decreased, the length of hospital stay of patients was reduced, and the standardized monitoring mode for pharmaceutical care of UAP patients was provided to ensure the safety and effectiveness of medication for patients.
  • Analysis on Clinical Medication of 16 Kinds of Key Monitoring Drugs in a Hospital From 2018 to 2019*1
    CHEN Qing-zhuang, LIANG Mei-fang, XIAO Xiao-dan
    2021, 18(4): 494-499. https://doi.org/10.13493/j.issn.1672-7878.2021.04-007
    Abstract ( 81 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To analyze the rationality of the clinical medication of key monitoring drugs in hospitals and to explore the effectiveness of control measures, and to provides reference for further improving supervision measures and rational drug use. Methods: The data of 16 kinds of key monitored drugs before and after the hospital control (2018 and 2019) were collected, and the rationality of the medication of key monitored drugs before and after the hospital control was compared and evaluated by drug utilization index (DUI) and ABC method (Pareto principle). Results: After the implementation of monitoring on the usage of 16 kinds of key monitored drugs, the amount of drug usage decreased significantly, and the rationality of drug usage was significantly improved. Conclusion: The ABC method and DUI method could effectively evaluate the rationality of the regulatory efficiency of key monitoring drugs, and helped to improve the efficiency of supervision and control, and curbed the irrational medication of such drugs.
  • Analysis on Distribution Characteristics and Drug Resistance of 41 Strains of Children Pneumonia Pathogenic Bacteria in Pediatric Department of a Hospital
    ZHAO Qiu-ting, YU Zhi-hui, YANG Ke-ke, MA Cai-hong, LI Xiao-xiao
    2021, 18(4): 500-503. https://doi.org/10.13493/j.issn.1672-7878.2021.04-008
    Abstract ( 61 ) Download PDF ( 8 )   Knowledge map   Save
    Objective: To analyze the distribution characteristics and drug resistance to antibacterial agents of 41 strains of children pneumonia pathogenic bacteria in pediatric department of a hospital. Methods: The medical records of 105 children diagnosed with pneumonia admitted to hospital from January 2017 to December 2019 were selected to analyze the culture and detection results of pathogenic bacteria in sputum samples of the children, as well as the drug resistance of different strains of pathogenic bacteria to antibiotics. Results: In the sputum samples from 105 children with pneumonia, 41 strains of pathogenic bacteria were detected. Of the pathogenic bacteria detected were Escherichia coli, Klebsiella pneumoniae, Streptococcus pneumoniae, Enterobacter cloacae, Staphylococcus aureus, Haemophilus influenzae, Enterococcus faecalis, Candida glabrata, Acinetobacter baumannii and Pseudomonas aeruginosa. Among them, there were 26 strains of Gram-negative bacteria (63.41%) and 13 strains of Gram-positive bacteria (31.71%). The resistance rates of the main pathogens in the Gram-negative bacteria to cephalosporins were higher, and the resistance rates of the main pathogens in the Gram-positive bacteria to penicillin and clindamycin were higher. Conclusion: Pediatric pneumonia is mainly caused by Gram-negative bacteria. In clinical treatment, sputum samples of children should be collected in time to detect the distribution of pathogenic bacteria and drug sensitivity test, and targeted antimicrobial drugs should be selected based on the drug sensitivity results to improve the clinical efficacy and safety.
  • Analysis on Distribution and Drug Resistance Characteristics of Clinically Isolated Pathogens in Intensive Care Units of a Hospital from 2017 to 2020
    QIN Xiao-tao, NI Wei-ying
    2021, 18(4): 504-509. https://doi.org/10.13493/j.issn.1672-7878.2021.04-009
    Abstract ( 66 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To explore the distribution of clinically isolated pathogens in ICU patients and their resistance to commonly used antibiotics, so as to provide reference for rational use of antibiotics in clinic. Methods: The results of pathogen culture and drug sensitivity test were collected in ICU patients from January 2017 to June 2020, and the distribution of pathogens and the resistance to antibiotics were analyzed. Results: A total of 510 strains of non-repetitive pathogens were isolated in ICU patients samples, of which30.98% were Gram-negative (G–) strains and 69.02% were Gram-positive (G+) strains. The TOP 3 isolates were Staphylococcus epidermidis, Escherichia coli and Staphylococcus hominis, accounting for 13.33%, 17.65% and 13.33%, respectively. The drug resistance rates of Acinetobacter baumannii to ciprofloxacin, levofloxacin and gentamicin in the common G– bacteria were all over 55.00%, while the drug resistance rates of these three drugs to Escherichia coli were all over 26.00%. Escherichia coli and Enterobacter aerogenes were more sensitive to imipenem and piperacillin-tazobactam. Methicillin-resistant Staphylococcus (MRSA) and Methicillin-resistant Coagulase-negative Staphylococcus (MRCNS) in common G+ bacteria were Pan-drug resistant to common antibiotics, and Enterococcus faecium had a relatively high resistance rate, but it was highly sensitive to tigecycline. MRSA and MRCNS were also highly sensitive to linezolid, vancomycin, tigecycline and teicoplanin. Conclusion: In ICU samples, the isolated strains were resistant to different antibiotics in different degrees, and the number of resistant strains increased. The drug resistance of ICU patients should be tested regularly or irregularly in clinical practice, and antibiotics should be selected reasonably based on the drug resistance.
  • Analysis on Pathogenic Bacteria Culture Results and Resistance Characteristics of Intracranial Infection Cerebrospinal Fluid from 462 Patients with HICH in a Hospital
    YANG Yang-xin
    2021, 18(4): 509-513. https://doi.org/10.13493/j.issn.1672-7878.2021.04-010
    Abstract ( 66 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To investigate the pathogen culture and drug sensitivity of intracranial infection cerebrospinal fluid in patients with hypertensive intracerebral hemorrhage (HICH), and to analyze the characteristics of antimicrobial resistance. Methods: A total of 462 patients with HICH admitted to a hospital from October 2016 to February 2020 were selected. The results of cerebrospinal fluid （CSF） pathogen culture and drug sensitivity test during surgical treatment were collected, and the infection and drug resistance of main pathogens in CSF were analyzed. And more infected and uninfected patients serum malondialdehyde (MDA), angiotensin-Ⅱ (Ang-Ⅱ), calcitonin (PCT) and C- reactive protein (CRP) level and the correlation between the severity of intracranial infection. Results: Of the 462 HICH patients, 74 had intracranial infection, among which 95 strains of pathogenic bacteria were isolated. Gram-negative bacteria accounted for 42.10%, Gram-positive bacteria for 54.74% and fungi for 3.16%. The drug susceptibility results showed that the resistance rates of Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae to imipenem were lower in the Gram-negative bacteria, while the resistance rates of Coagulase negative Staphylococcus, Staphylococcus aureus and Enterococcus faecalis to vancomycin were lower in the Gram-positive bacteria. Infection in patients with serum MDA, Ang-Ⅱ, PCT and CRP significantly higher than the measured values are uninfected (P<0.05), and the degree of postoperative intracranial infection gradually aggravate, serum MDA, Ang-Ⅱ, PCT and CRP level was on the rise (P<0.05). Serum MDA, Ang-Ⅱ, PCT and CRP level were positively correlated with the degree of postoperative intracranial infection (P<0.05). Conclusion: CSF of patients with pathogenic bacteria culture and drug susceptibility analysis, and through the serum MDA, Ang-Ⅱ, PCT and CRP level detection, to guide HICH postoperative intracranial infection in patients with the reasonable choice of antibiotics, were helpful for the early diagnosis of intracranial infection and prevention.
  • Pharmaceutical Care of the Anti-infection Treatment in a Patient with Meningitis Caused by Multiple Drug-resistant Organisms
    LU Yuan-yuan, PAN Li-li, ZHANG Xiang-fu, JIANG Hong, ZHANG Liang
    2021, 18(4): 570-574. https://doi.org/10.13493/j.issn.1672-7878.2021.04-027
    Abstract ( 62 ) Download PDF ( 7 )   Knowledge map   Save
    Objective: To explore the pharmaceutical care method of the anti-infection treatment in a patient with meningitis caused by multiple drug-resistant organisms (MDRO). Methods: Clinical pharmacists participated in the anti-infection treatment of the meningitis patient infected by MDRO, and analyzed the selection of therapeutic agents, the blood-brain barrier permeability of antibacterial drugs and the mechanism of neutropenia induced by antibacterial drugs.Then based on the current adverse drug reaction reports, it was proposed that all suspicious drugs should be stoped using and a individualized treatment should be implemented after neutropenia, which were adopted. Results: After the pharmacist's suggestions were adopted by clinicians, the patient's symptoms of infection and the neutropenia caused by antibacterial drugs improved rapidly, even return to normal. Conclusions: The phenomenons of irrational antibacterial use and generation of iatrogenic MDRO were reduced effectively through the pharmaceutical care for the meningitis patient infected by MDRO.
  • Analysis on Adverse Drug Reactions of Antiviral Drugs during Medication of Patients with COVID-19 and Its Pharmaceutical Care*1
    GE Hong-lei, LIU Ting-ting, YE Hua, ZHENG Qiong-na, SHAO Chuan-feng, XIAO Zhong-xiang
    2021, 18(4): 575-579. https://doi.org/10.13493/j.issn.1672-7878.2021.04-028
    Abstract ( 71 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To analyze the adverse drug reactions (ADRs) of antiviral drugs during medication of patients with COVID-19 and its pharmaceutical care. Methods: The medical records of 102 COVID-19 patients, who had ADRs after receiving antiviral drugs combination therapy, were collected. The involved organs/system, clinical manifestations and other situations of ADRs were analyzed in order to explore the implementation of pharmaceutical care and the relationship between ADRs and gender, age and underlying diseases Results: Of 102 COVID-19 patients, 70 cases (68.63%) had ADRs caused by antiviral drugs. The organs/systems involved in ADR mainly included digestive system, blood system, nervous system, liver, skin and heart. The occurrence of ADRs had no correlation with patients' gender and age(P>0.05), but has correlation with patients' underlying diseases(P< 0.05). Conclusion: When the COVID-19 patients were treated with combination of multiple antiviral drugs, monitoring adverse reactions and strengthening pharmaceutical care should be carried out in order to ensure the safety and effectiveness of medication.
  • Investigation and Analysis on Knowledge about Drugs and Needs of Medication Education in Patients with Coronary Heart Disease*1
    Qi Liu-ying, Gao Yue
    2021, 18(4): 580-583. https://doi.org/10.13493/j.issn.1672-7878.2021.04-029
    Abstract ( 70 ) Download PDF ( 7 )   Knowledge map   Save
    Objective: To investigate and analyze the knowledge about drugs and needs of medication education in patients with coronary heart disease (CHD) so as to provide reference for clinical pharmacists to participate in medication guidance. Methods: We collected the self-designed questionnaires of 240 inpatients with CHD from June to December 2019 to understand the patients' knowledge about the disease and drugs and the needs of medication education, and analyzed them. Results: All 240 questionnaires were filled qualifiedly and collected. In terms of knowledge about disease, only 41.67% of the patients had a clear definition of CHD, and 36.67% of the patients could answer more than 3 CHD related risk factors. In terms of knowledge about drugs, all patients knew the usage and dosage of the drug very well, but had a low awareness of the purpose of medication and precautions. 86.67% of the patients said that it was necessary for clinical pharmacists to provide medication guidance and individualized medication education. Conclusion: CHD patients had a vague understanding of diseases and drugs, and the demand for medication education was very high. It was demonstrated that it is of great significance for clinical pharmacists to participate in medication management of CHD patients, which could improve the patients' medical experience, enhance the medication compliance of patients and ensure the safety of medication.
  • Analysis on Cost-effectiveness of 4 Common Medication Regimens in Children with Bronchial Pneumonia*1
    ZHOU Sha-sha, CHEN Xia
    2021, 18(4): 601-604. https://doi.org/10.13493/j.issn.1672-7878.2021.04-036
    Abstract ( 89 ) Download PDF ( 11 )   Knowledge map   Save
    Objective: To analyze and compare the cost-effectiveness of 4 Common Medication Regimens (cefuroxime, cefoperazone-sulbactam sodium, cefuroxime combined with azithromycin, and cefoperazone-sulbactam sodium combined with azithromycin) for children with bronchopneumonia so as to explore the medication plan with the optimal economic characteristics. Methods: A total of 116 children with bronchial pneumonia admitted from January to December 2019 were selected and divided into cefuroxime group (21 cases), cefoperazone-sulbactam sodium group (21 cases), cefuroxime and azithromycin group (36 cases), and cefoperazone-sulbactam sodium and azithromycin group (38 cases) according to different therapeutic agents. Based on the cost-effectiveness analysis (CEA) method of pharmacoeconomics,the relationship between the effectiveness and cost of different drug treatments was analyzed to find the optimal medication plan. Results: The cost-effectiveness (C/E) ratios of 4 kinds of drug therapies for children with bronchopneumonia were 37.68, 38.48, 32.38 and 46.21, respectively. The cost was higher in the group of cefoperazone-sulbactam sodium combined with azithromycin than that in the group of cefuroxime combined with azithromycin, whose incremental C/E ratio was 476.74 (cost for each additional cure value). Conclusion: Based on the CEA, the drug therapy of cefuroxime combined with azithromycin was optimal in the 4 common medication regimens for children with bronchopneumonia.
  • Influence of Integrated Traditional Chinese and Western Medicine on Efficacy and Improvement of T-lymphocyte Subsets in Patients with MDR-PTB*1
    OU-YANG Bing, LIU Xing, LI Hai-wen, ZHAO Li-ping, LENG Yan-duo, LIU Yuan
    2021, 18(4): 605-608. https://doi.org/10.13493/j.issn.1672-7878.2021.04-037
    Abstract ( 65 ) Download PDF ( 3 )   Knowledge map   Save
    Objective: To explore the influence of integrated traditional Chinese and Western medicine on the clinical efficacy and improvement of T-lymphocyte subsets in patients with multi-drug resistant pulmonary tuberculosis (MDR-PTB). Methods: A total of 150 MDR-PTB inpatients from June 2019 to June 2020 were selected and divided into combination therapy group and routine group based on the random number table method, 75 cases in each group. Patients in the routine group were treated with conventional anti-tuberculosis chemotherapy drugs, and patients in the combination therapy group were treated with integrated traditional Chinese and Western medicine on the basis of the routine group. The sputum negative conversion rate and the chest imaging improvement rate of 2 groups were compared after 6 months of treatment. The changes of main symptom scores and immune function indexes (CD3, CD4, CD8, CD4 / CD8) before and after treatment were also observed. Results: After treatment, the scores of cough, expectoration, hemoptysis and hot flashes in the combination therapy group were lower than those in theroutine group (P<0.05), and the sputum negative conversion rate, lung lesion absorption rate and the immune function indexes (CD3, CD4, CD8, CD4/CD8) were higher than those in theroutine group (P<0.05). Conclusion: For the MDR-PTB patients, the integrated traditional Chinese and Western medicine could effectively alleviate the clinical symptoms, improve the immune function and promote the negative transformation of sputum bacteria , and had definite clinical efficacy.