KANGGANRAN YAOXUE

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  • 2021 Volume 18 Issue 6
    Published: 25 June 2021
      
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  • Clinical Manifestations of Mycoplasma Pneumoniae Infection and Its Research Progress of Medication
    LIU Yu-ying
    2021, 18(6): 777-780. https://doi.org/10.13493/j.issn.1672-7878.2021.06-001
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    Mycoplasma pneumoniae disease is a kind of respiratory diseases. Because of its special pathogenic mechanism, it not only causes damage to the respiratory tract of patients, but also may induce other systemic diseases and produce a variety of complications, which greatly threaten the lives of patients. It has been found that the high incidence of Mycoplasma pneumoniae disease population is in children, and the scope and symptoms of children's infection are gradually increasing. Due to the widespread use of antibacterial drugs, the pathogens produce drug resistance, which leads to great difficulty in clinical treatment. In this paper, the literatures of clinical manifestations and clinical treatment of Mycoplasma pneumoniae infection were reviewed, and the research progress was analyzed.
  • Research Progress on Clinical Pharmacologic Effects of Matrine and Oxymatrine in Prevention and Treatmet for Stomatopathy
    ZHANG Ming-fa, SHEN Ya-qin
    2021, 18(6): 781-784. https://doi.org/10.13493/j.issn.1672-7878.2021.06-002
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    Oxymatrine can protect periodontal ligament cells from injury of lipopolysaccharide, and inhibit periodontal inflammation and alveolar resorption. Matrine can treat oral ulcers in rabbits induced by chemical burning and epidemic parotitis, and prevent adhesion of Candida albicans to human oral mucosal epithelial cells. All of these are related to broad-spectrum anti-bacteria, anti-virus, anti-inflammation, and immunoregulation of matrine and oxymatrine. Matrine and oxymatrine have the effects against cephalocervical tumors. The compound Kushen injection, composed of matrine and oxymatrine, has been used to prevent and treat the radiate stomatitis caused by radiotherapy for head and neck tumors in clinic. In this paper, the literatures on the clinical pharmacological effects of matrine and oxymatrine in prevention of oral diseases are reviewed, and the research progress of matrine is analyzed.
  • Influence of Ear Canal Secretion's Bacterial Culture and Drug Sensitivity Test Results on Rational Usage of Antimicrobial Agents in 66 Patients with CSOM
    LIU Hong-li
    2021, 18(6): 785-788. https://doi.org/10.13493/j.issn.1672-7878.2021.06-003
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    Objective: To analyze the influence of ear canal secretion's bacterial culture and drug sensitivity test results on rational usage of antimicrobial agents in 66 elderly patients with chronic suppurative otitis media (CSOM). Methods: The medical records of 66 elderly patients with CSOM admitted to our hospital from January 2018 to October 2019 were selected. The bacterial culture and drug sensitivity test results of ear canal secretions were calculated, and the distribution of pathogenic bacteria in the secretions and the characteristics of drug resistance to common antibacterial drugs (penicillin, erythromycin, rifampicin, vancomycin, etc.) were analyzed. Results: 70 strains of pathogenic bacteria were cultured from the secretions of 66 CSOM patients, of which 44.29% were Gram-positive bacteria, 41.43% were Gram-negative bacteria and 14.28% were fungi. In the Gram-positive bacteria, the main pathogens (Staphylococcus epidermidis and Staphylococcus aureus) were highly sensitive to vancomycin, rifampicin, tigecycline, linezolid and furantoin. The main Gram-negative bacteria (Pseudomonas aeruginosa and Klebsiella pneumoniae) were highly sensitive to imipenem, meropenem, ceftazidime, piperacillin-tazobactam and cefoperazone/sulbactam. The main fungi (Candida albicans and Aspergillus) were also sensitive to 5-fluorocytosine, nystatin, amphotericin B, etc.. Conclusion: The main pathogens of CSOM infection were Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans and Aspergillus. In clinical treatment, antibacterials with high sensitivity rate could be selected based on the drug sensitivity test results of these pathogens to ensure the clinical efficacy.
  • Analysis on Distribution of Pathogenic Bacteria and Drug Sensitivity Test Results of Ventilator-associated Pneumonia in Pediatric Intensive Care Unit of a Hospital
    CHANG Yuan-yuan
    2021, 18(6): 789-793. https://doi.org/10.13493/j.issn.1672-7878.2021.06-004
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    Objective: To analyze the related factors, pathogenic bacteria component and drug sensitivity test results of ventilator-associated pneumonia (VAP) in pediatric intensive care unit (PICU) of a hospital. Methods: Clinical data of 369 children with VAP admitted to PICU from January 2018 to January 2020 were selected. Based on the incidence of VAP, they were divided into VAP group (n=71) and non-VAP group (n=298). The factors related with VAP, the component of pathogenic bacteria and the characteristics of antibacterial resistance in PICU patients were analyzed. Results: In the clinical data of 369 children, 161 strains of pathogenic bacteria were isolated from the samples of 71 children, including 13.04% of Gram-positive bacteria, 65.84% of Gram-negative bacteria and 21.12% of fungi. Gram-negative bacteria were Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli to imipenem, ciprofloxacin resistance were less than 30.00%. There were different degrees of drug resistance to cefoperazone-sulbactam sodium, cefoxitin and other antibaterial drugs, especially the drug resistance rate of cefotaxime reached 100.00%. In the gram-positive bacteria, the resistance rates of Streptococcus pneumoniae and Staphylococcus aureus to penicillin and clindamycin were higher than 70.00%, the resistance rates to chloramphenicol, gentamicin and levofloxacin were lower, and the sensitivity rates to vancomycin and quinupristin were the highest. Candida albicans, Candida glabrata and Mucor were more sensitive to amphotericin B, voriconazole and itraconazole. The results of univariate and multivariate logistic regression analysis showed that the occurrence of VAP was correlated with the times of sputum aspiration, the times of catheterization, the duration of mechanical ventilation, and the length of PICU hospitalization (P<0.05). Conclusion: PICU children with VAP mainly Gram-negative bacteria infection, the occurrence of VAP risk factors mainly more times of sputum aspiration, more times of catheterization, longer mechanical ventilation time, longer of mechanical ventilation and tube PICU long hospitalization time and other factors. Clinical practice should based on the results of drug susceptibility and inducing factors, prevention and control of related intervention measures actively so as to avoid or reduce the VAP.
  • Analysis on Clinical Processing and Usage of Traditional Chinese Medical Extraction Formula in a Hospital and Its Typical Cases*1
    LIU Te-jin, PENG Wei-wen, LUO Qing, HE Xi-jun, LIANG Wei-qi
    2021, 18(6): 794-796. https://doi.org/10.13493/j.issn.1672-7878.2021.06-005
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    Objective: To analyze the clinical processing and usage of traditional Chinese medical extraction (TCME) formula in a hospital and its typical cases. Methods: From the origin and development of TCME formula and its applicability in Zhongshan area, the clinical usage of TCME formula in hospitals were summarized and analyzed. Results: With the development of traditional Chinese medicine (TCM) to treat a disease before its onset", TCME formula has become one of the important methods of health care and chronic disease management widely accepted by the public. It has obtained good results by giving full play to the characteristic advantages of TCM treatment and carrying out TCME service. Conclusion: TCME formula in health care and chronic disease conditioning, play an important therapeutic role, favored by the people.
  • Analysis on Current Situation of Off-label Usage of 3 Kinds of Commonly Used Antibacterials in Respiratory Department of a Hospital and Their Intervention Strategy
    WANG Qiang, LIU Yuan
    2021, 18(6): 797-800. https://doi.org/10.13493/j.issn.1672-7878.2021.06-006
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    Objective: To analyze the current status of off-label usage of common antibacterials in respiratory department of a hospital, and to explore the related intervention strategies. Methods: The medical records of 1 068 inpatients in the respiratory department of the hospital (from January to December 2020) were selected to statistically analyze the off-label usage of antibacterials and the rate, type and route of off-label usage of all kinds of antibacterials. Based on the latest version expert consensus approved by China Food and Drug Administration (CFDA), the guidelines and the requirements of the drug instructions, to judge whether the drug was used beyond the specification. The types of off-label drug usage, the current situation of off-label drug usage of commonly used antibacterials, and the distribution of off-label drug usage in physicians with different professional titles and qualifications and patients of different genders and ages were analyzed. Results: In the 1 068 antibacterial prescriptions, 235 prescriptions for off-label drug usage accounted for 22.00%, among which the number of prescriptions for over-indication and over-usage accounted for 60.43% and 28.09%. There was a correlation between the distribution of off-label drug in physicians with different professional titles and qualifications and patients of different genders and ages (P<0.05). Among the off-label prescriptions of common antibacterials,most those of cefuroxime and meropenem existed the situations of overdosage, while most those of cefotaxime existed the situations of use out of indication. Conclusion: The commonly used antibacterials in respiratory department were commonly used off-label, and most of them were used in excess of usage and dosage and indication. In addition, it was more common that the off-label prescriptions were given to elderly patients by qualified physicians with middle or senior professional title. Therefore, clinical usage of antibacterials should be standardized, clinical management system should be strengthened, relevant laws and regulations should be improved, drug education should be standardized and other measures should be taken to reduce the risk of off-label drug usage and to prevent and treat diseases scientifically.
  • Analysis on Pathogenic Bacteria Classification and Drug Resistance of 82 Respiratory Tract Infection Patients
    FAN Xia-nü
    2021, 18(6): 801-804. https://doi.org/10.13493/j.issn.1672-7878.2021.06-007
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    Objective: To explore the pathogen distribution and drug resistance of 82 patients with respiratory tract infection. Methods: Data of 82 patients with respiratory tract infection admitted to author's hospital from October 2019 to October 2020 were selected. Pathogenic bacteria identification and drug sensitivity detection were carried out on sputum samples. The species and proportion of pathogenic bacteria in respiratory tract infection, drug resistance rate of main gram positive bacteria and main gram negative bacteria to antibacterials were analyzed. Result: A total of 178 strains of pathogens were detected in 82 patients with respiratory tract infection, including 97 strains of gram positive bacteria(54.49%), in which Staphylococcus aureus accounted for the highest proportion, followed by Streptococcus pneumoniae; 75 strains of gram negative bacteria(42.13%) were detected, in which Pseudomonas aeruginosa accounted for the highest proportion; 6 strains of fungi(3.37%) were detected, in which Candida albicans accounted for the highest proportion. Among the gram positive bacteria, Streptococcus pneumoniae showed higher drug resistance to antibacterial agents. Enterococcus faecium showed high drug resistance to penicillin. Staphylococcus aureus showed relatively high drug resistance to levofloxacin and penicillin.Gram negative bacteria showed high drug resistance to gentamicin, ciprofloxacin, ampicillin and ceftriaxone. Conclusion: The common pathogenic bacteria of patients with respiratory tract infection are Staphylococcus aureus(gram positive bacteria),and pathogenic bacteria showed certain resistance to commonly used antibacterials in clinical practice. It is necessary to explore the distribution of pathogenic bacteria and drug resistance in clinical treatment, so as to give target treatment.
  • Analysis on Pathogen Distribution and Drug Resistance of 76 Lupus Nephritis Patients with Hospital Infection
    Dong Yan-xin
    2021, 18(6): 805-807. https://doi.org/10.13493/j.issn.1672-7878.2021.06-008
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    Objective: To analyze the pathogen distribution and drug resistance of 76 patients with lupus nephritis(LN). Methods: Data of 76 patients with LN admitted to hospital from July 2018 to October 2020 were selected. Infection-related secretions samples were collected, and pathogen culture and drug sensitivity test were conducted to analyze the pathogens distribution, drug resistance rate of main gram positive and gram nagative bacteria. Results: 85 strains were isolated from 76 samples, including 52 strains of gram positive bacteria (61.18%), most of which were Staphylococcus aureus and Staphylococcus epidermidis; 25 strains of gram negative bacteria (29.41%), among which Escherichia coli and Klebsiella pneumoniae were the main strains. The main gram positive bacteria Staphylococcus aureus showed higher drug resistance rates to ampicillin and sulfamethoxazole-trimethoprim, and Staphylococcus epidermidis showed higher drug resistance rates to sulfamethoxazole-trimethoprim, gentamicin and furantoin, but they showed no drug resistance to vancomycin. The main gram negative bacteria Escherichia coli and Klebsiella pneumoniae showed higher drug resistance rates to ampicillin and piperacillin, in which Klebsiella pneumoniae showed 100.00% drug resistance rate to ampicillin and none drug resistance to imipenem. Conclusion: Most of the pathogens of nosocomial infection in LN patients were gram positive bacteria, followed by gram negative bacteria. In order to improve clinical efficacy and prognosis, antibacterials should be selected reasonably based on the results of pathogen culture and antibacterialresistance rate.
  • Evaluation on Eradication Efficacy and Economics of Quadruple Therapy of Con-taining Clarithromycin Tablets of Different Dosage Forms in Patients infected by Hp
    CAO Cheng, ZHU Yan-xia, WANG Yu, WANG Li-xin, YAN Xin-xin
    2021, 18(6): 808-811. https://doi.org/10.13493/j.issn.1672-7878.2021.06-009
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    Objective: To evaluate the eradication efficacy and pharmacoeconomics of quadruple therapy containing clarithromycin tablets of different dosage forms in patients infected by Helicobacter pylori (Hp）. Methods: From December 2018 to November 2019, 102 patients with Hp infection confirmed by 14C-UBT and newly diagnosed by bismuth quadruple therapy were selected and divided into group A (33 cases), Group B (43 cases) and Group C (26 cases) based on different therapeutic agents. The efficacy of each group was examined by 14C-UBT after 4-8 weeks of drug withdrawal. The total effective rate and the efficacy of eradication-cost difference and different regimen of cost-effectiveness ratio (C/E) and the incremental cost-effectiveness ratio (ΔC/ΔE), and sensitivity analysis to weight by a 15% lower the drug prices and the drug cost and their ΔC/ΔE value were compared. Results: The total effective rates of the 3 groups were 87.88%, 86.05% and 65.38%, respectively. With group A as the control group, there were no statistically significant differences in the total effective rate between groups A and B (P>0.05), while the total effective rate between groups A and C was statistically significant (P<0.05). 3 groups of patients with drug costs were 357.52, 474.52, and 474.52 RMB/person, the eradication of efficient C/E of 4.07, 5.52 and 7.26, respectively, B and C in the two groups compared with group A ΔC/ΔE 61.58 and 5.20, respectively, the cost-effectiveness results of sensitivity analysis to weight were supported. Conclusions: The efficacy and pharmacoeconomics of clarithromycin tablets in Hp eradication program were better than those of sustained-release tablets, which was more worthy of recommendation for Hp eradication therapy.
  • Analysis on Risk Factors of Postoperative Infection in Patients with Acute Appendicitis and Its Preventive Measures
    SONG Li-zhong
    2021, 18(6): 870-873. https://doi.org/10.13493/j.issn.1672-7878.2021.06-028
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    Objective: To analyze the risk factors of postoperative infection in patients with acute appendicitis and explore effective preventive measures. Methods: Data of 80 patients with acute appendicitis admitted to author's hospital from March 2018 to March 2020 were selected, and they were divided into infected group and non-infected group according to the occurrence of infection.The main clinical data of patients in the two groups were compared, and the independent risk factors of postoperative infection in patients with acute appendicitis were analyzed. Result: The level of albumin of infected group was lower than that of non-infected group(P<0.05), and the levels of age, white blood cell count, C-reactive protein and incidence of diabetes in infected group were higher than that in non-infected group(P<0.05).The results of univariate analysis showed that age, course of disease, white blood cell count, pathological type, operation time, resection method and incision type were the risk factors for postoperative infection in patients with acute appendicitis(P<0.05).The results of multivariate analysis showed that age, course of disease, white blood cell count, pathological type, operation time, resection method and incision type were independent risk factors for postoperative infection in patients with acute appendicitis(P<0.05). Conclusion: There were many risk factors of postoperative infection in patients with acute appendicitis, and timely and effective clinical measures could reduce the incidence of infection.
  • Analysis on Related Factors of 454 Cases of Adverse Drug Reactions in a Hospital from 2018 to 2020 and Its Countermeasures
    SHI Rong-hua, SHI Yu-ping, HU Zi-shu, GAO Li-hua
    2021, 18(6): 884-888. https://doi.org/10.13493/j.issn.1672-7878.2021.06-032
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    Objective: To analyze the occurrence characteristics and the causes of ADRs in a hospitals, and to provide reference for rational drug use in clinic. Methods: A total of 454 reports of ADRs cases reported from hospital information system during 2018 to 2020 were selected to analyze the gender, age and other relevant informations of the patients with ADRs, as well as related factors such as administration methods involved, severity of ADRs, suspected drug types and organs/systems involved in ADRs. The causes and characteristics of ADRs were analyzed and the countermeasures were suggested. Results: In the 454 cases of ADRs, males were more than females, and the incidence of ADRs was the highest in middle-aged and elderly patients over 45 years old (212 cases, 46.70%). The TOP 3 drugs involved in ADRs were anti-infective drugs (38.77%), hematologic drugs (8.59%) and digestive system drugs (6.17%). The incidence of ADRs caused by intravenous infusion in the drug delivery route was 66.08%.ADRs induced by subcutaneous injection were the least (0.44%).In 454 ADRs, general adverse reactions were the most common (299 cases, accounting for 65.86%). The ADRs involved the system/organs mainly in the skin and its appendages (58.37%). Conclusions: In daily monitoring of ADRs of anti-infective drugs, people over 60 years old and intravenous administration route should be monitored. The lesions of skin and appendages caused by ADRs are important signal characteristics of ADRs. In the course of clinical drug treatment, the above factors should be monitored to ensure the safety of clinical drug use.
  • Pharmaceutical Care for Clinical Therapy of 1 Patient of Disseminated Nocardia Infection
    GAO Si-ming, CHEN Lan
    2021, 18(6): 892-894. https://doi.org/10.13493/j.issn.1672-7878.2021.06-034
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  • Analysis on Clinical Pharmacists Participated in Clinical Medication in a Patient of Cellulitis of Lower Extremity with IMODS and Its Pharmaceutical Care*1
    DONG Ya-fen, Qiu Yan
    2021, 18(6): 895-897. https://doi.org/10.13493/j.issn.1672-7878.2021.06-035
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    Objective: To explore the clinical medication in clinical pharmacists participated in treatment of a patients with cellulitis of lower extremity with infectious multiple organ dysfunction syndrome (IMODS) and its pharmaceutical care. Methods: Clinical pharmacists participated in the consultation of a patient with lower extremity cellulitis with IMODS, and combined with the physiological and pathological conditions of the patient, the culture of pathogenic bacteria and the characteristics of antibacterial drugs action, putting forward to individualize anti-infection medication plan and implemented pharmaceutical care. Results: After the clinicians adopted the anti-infective medication regimen, cefotiam was stopped, linezolid was replaced, and fluconazole was added for anti-fungal infection medication. The symptoms were controlled and therapeutic efficacy was achieved. Conclusion: The participation of clinical pharmacists in the consultation of anti-infective medication plays a positive role in promoting the improvement of patients' condition and rational usage of antibacterials.
  • Clinical Pharmacists Participating in Pharmaceutical Practice of Antiviral Medication in Lung Cancer Patients with HBsAg Positive
    GONG Yin-hua, ZHANG Xiao-Gang, MA Ya-Bin
    2021, 18(6): 898-900. https://doi.org/10.13493/j.issn.1672-7878.2021.06-036
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    Objective: To explore the pharmaceutical practice process of clinical pharmacists involved in antiviral medication strategies for lung cancer patients with hepatitis B surface antigen (HBsAg) positive during perichemotherapy, and to provide reference in the clinical safety and rational drug use for such patients. Methods: Clinical pharmacists participated in the consultation, and assisted the clinical formulation of individualized drug regimen and necessary antiviral medication strategy by combining the actual patient characteristics (liver function, two-half quantification, HBV-DNA load, etc.) and relevant guidelines and literatures. Results: After the participation of clinical pharmacists in clinical medication, the standard usage of entecavir antiviral therapy and the implementation of the whole process of pharmaceutical care, liver function and other indicators were relatively stable, effectively promoting the smooth development of follow-up chemotherapy for lung cancer patients. Conclusion: Clinical pharmacists participated in the treatment team of clinical tumor patients and carried out pharmaceutical care, which improved the rationality of clinical medication, reduced the occurrence of adverse events, and played a positive role.
  • Exploration on Out-patient Pharmacy Management Mode Based on Normalization of COVID-19 Epidemic Prevention and Control*1
    HE Wei-ping, LI Jin-dong, LI Na, LI Zhi-qin, HUA Hui-lian
    2021, 18(6): 906-908. https://doi.org/10.13493/j.issn.1672-7878.2021.06-039
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    Objectiv: To analyze the management mode of out-patient pharmacy under the situation of COVID-19 epidemic prevention and control in order to avoid nosocomial infection and to promote pharmaceutical care. Methods: Based on the transmission mode of COVID-19, environmental health management was strengthened to contain the spread of the virus and ensure environmental safety. The long-term management mechanism was established and improved to promote the development of pharmaceutical care and reduce the frequency of patients with chronic diseases to and from the hospital. The "internet plus pharmaceutical care" was actively promoted to ensure the normal and orderly development of the work. By strengthening service management and improving the awareness of window service, the quality of window services was improved to achieve the goal of implementing the regular epidemic management.Results and Conclusions: Through strengthening environmental health management, establishing and improving long-term management mechanism, and promoting "internet plus pharmaceutical care", cross-infections were avoided, the spread of COVID-19 was effectively suppressed, and medication safety of patients was improved.
  • Clinical Efficacy of Cefoperazone-sulbactam Sodium Combined with Moxifloxacin in Patients with CAP and Its Influence on Symptom Improvement
    XIE Xiu-feng
    2021, 18(6): 913-916. https://doi.org/10.13493/j.issn.1672-7878.2021.06-041
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    Objective: To evaluate the clinical efficacy of cefoperazone/sulbactam sodium combined with moxifloxacin in patients with community-acquired pneumonia (CAP) and its influence on symptom improvement. Methods: 60 patients with CAP admitted to author's hospital from July 2017 to April 2018 were selected as the research subjects,and they were divided into combination group (n=30) and single group (n=30) based on random number table method. Patients in the combination group were given cefoperazone-sulbactam sodium combined with moxifloxacin,and patients in the single group were given moxifloxacin alone.The changes of clinical symptom severity index (PSI) score before and after treatment,the time of major clinical symptoms to normalize after treatment,the changes of procalcitonin (PCT),D-dimer,C-reactive protein (CRP) levels and the total effective rate of clinical medication were compared between the two groups. Results: PSI score in both groups decreased after treatment compared with before treatment,and PSI score in combination group was lower than that in single group (P<0.05). The recovery time of clinical symptoms in the combination group was earlier than that in the single group (P<0.05),the levels of PCT,D-dimer and CRP in the combination group were significantly lower than those in the single group (P<0.05),and the total effective rate of clinical medication was higher than that in the single group (96.67% vs 80.00%,P<0.05). Conclusion: The combination of cefoperazone-sulbactam sodium and moxifloxacin could effectively alleviate the clinical symptoms of CAP patients,improve the level of inflammatory factors,and enhance the clinical efficacy.
  • Clinical Efficacy of Combination of Sofosbuvir/velpatasvir and Ribavirin in CHC Patients with Cirrhosis and Its Influence on HCV-RNA Negative Conversion
    TANG zhan-zhan
    2021, 18(6): 917-919. https://doi.org/10.13493/j.issn.1672-7878.2021.06-042
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    Objective: To analyze the efficacy of combination of sofosbuvir/velpatasvir and ribavirin in patients with chronic hepatitis C (CHC) with cirrhosis and its influence on HCV-RNA negative conversion. Methods: The medical records of 60 CHC patients with cirrhosis admitted to our hospital from January 2019 to January 2020 were selected and divided into the single-agent group and double-agent group based on different drug regimens, with 30 cases in each group. Patients of the single-agent group were only given sofosbuvir/velpatasvir, while those of the double-agent group were given sofosbuvir/velpatasvir and ribavirin. the therapeutic effects (HCV-RNA overcast rate, rate of sustained virological response, viral recurrence, virology, bounce rate), and the adverse reaction (anemia, bone marrow suppression, headache, loss of appetite, fatigue) rate of 2 groups were compared after treatment, while the changes of liver function index (liver stiffness, propagated, creatinine, AST, TBIL, ALT) were observed before and after treatment. Results: Following up for 6 months, the HCV-RNA overcast rate and sustained virological response rate of the double-agent group were higher than those of the single-agent group (P<0.05), while the viral bounce rate and virological relapse rate was lower than those of the single-agent group (P<0.05). After treatment, the liver hardness, creatinine, AST, TBIL and ALT of the double-agent group were lower than those of the single-agent group (P<0.05), and the ALB was higher than those of the single-agent group (P<0.05). During the treatment, the adverse reaction rate of the double-agent group was lower than that of the single-agent group (P<0.05). Conclusions: In the treatment of CHC patients with cirrhosis, the combination of solophobvavivpatavir and ribavirin can effectively improve liver function indexes, increasing HCV-RNA negative conversion and persistent viral response rate, with high safety.