KANGGANRAN YAOXUE

Archive

  • 2021 Volume 18 Issue 8
    Published: 25 August 2021
      
  • Select all
    |
  • Research Progress in Clinical Pharmacological Effects of Matrine and Oxymatrine in Mycotic and trichomonas Vaginitis
    ZHANG Ming-fa, SHEN Ya-qin
    2021, 18(8): 1083-1087. https://doi.org/10.13493/j.issn.1672-7878.2021.08-001
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Matrine and oxymatrine have a widespread bioactivities, including protection of organs(heart, liver, lung, kidney, brain and blood vessel), positive inotropic action, negative chronotropic action, antiarrhythmia, the effect of increasing leukocyte, antiasthma, antiulcer, anti-fibrogenesis, the central nervous pharmacological action(sedation, hypnogenesis and analgesia), antitumor, immunoregulation, anti-bacteria, anti-virus, anti-parasite and anti-inflammation. In gynecologic domain, matrine and oxymatrine have the effects of anit-gynecologic tumors, and could protect epithelial cells of mamma, endometrium and vagina, and antagonize inflammatory pathologic change of epithelial cells induced by various pathogenic factors. Clinically, they have been used in the treatment of various cervicitis and vaginitis, and have also been tried in the treatment of breast, ovarian, cervical and endometrial cancer. In this paper, the pharmacological effects of matrine and oxymatrine in clinical treatment of mycotic and trichomonas vaginitis have been reviewed, and their research progress have been analyzed.
  • Evaluation on Optimization and Its Quality of Valsartan Capsule Formulation
    PING Jia-jing
    2021, 18(8): 1088-1092. https://doi.org/10.13493/j.issn.1672-7878.2021.08-002
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To study the formulation technique of valsartan capsules and its influence on quality control. Methods: The single factor design was used to select the formulation process and to prepare valsartan capsules according to the optimized formulation process, with the in vitro release behavior as the optimal index. The prepared capsules were sampled at 0, 5 and 10 days under different conditions to investigate their release behavior and stability in vitro. Results: The capsule, prepared based on the optimized prescription-6, was placed at 60 ℃, and the measured in vitro release degree decreased seriously, indicating that the valsartan capsule had certain sensitivity to temperature. Conclusion: The stability of the valsartan capsule prepared at 40 ℃ and 90% RH/light (with packaging) were qualified.
  • Analysis of Clarithromycin Prescriptions Comments and Potential Drug Interactions in Out-patient Internal Medicine of a Hospital
    ZHENG Xiao-jun, ZHANG Gui-fen, WANG Jian
    2021, 18(8): 1093-1097. https://doi.org/10.13493/j.issn.1672-7878.2021.08-003
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the rationality of clarithromycin prescriptions and drug combination in out-patient department, and to provide reference for rational drug use in clinic. Methods: Using the hospital information system (HIS), 871 prescriptions containing clarithromycin were collected from the out-patient internal medicine department from October to December 2020 to analyze the rationality of drug usage and the reasons for irrational drug use. Results: In 871 prescriptions containing clarithromycin, the patients were mainly in the age group of 30 to 60 years old. Most of the patients were in gastroenterology department and general internal medicine department, and the main prescription diagnosis item was Helicobacter pylori infection. Reasons for unreasonable prescriptions were mainly "unreasonable use of antibacterials" and "incomplete writing of clinical diagnosis". The prescriptions combined with proton pump inhibitors accounted for 87.14%, and the prescriptions with potential drug interactions were more common. Conclusion: In hospital out-patient medical patients, the clarithromycin unreasonable drug usage exists, administrative departments should strengthen the clinical rational usage of antibacterial agents and the combination of management, improve clinical awareness of possible drug interaction potential, and to improve pharmacists' ability to check prescriptions so as to promote the rationality of clarithromycin clinical medication and safety.
  • Analysis of Drug Resistance and Multi-drug Resistance of 504 Strains of Mycobacterium Tuberculosis to First-line Anti-tuberculosis Drugs in Xiamen Area
    DONG Chun-ping, YAO Xiang-yang, YANG Ying-hui, WU Ding-hui
    2021, 18(8): 1098-1102. https://doi.org/10.13493/j.issn.1672-7878.2021.08-004
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the drug resistance and multi-drug resistance of Mycobacterium tuberculosis (MTB) to first-line anti-tuberculosis drugs in Xiamen area, and to provide a reference for rational drug use of tuberculosis patients. Methods: The medical records of 504 tuberculosis patients hospitalized and treated in the hospital from January to December 2019 were collected, and the distribution characteristics of culture-positive MTB infection in the sputum and duct lavage fluid samples were analyzed.The resistance characteristics of MTB to isoniazid (INH), rifampicin (RFP), streptomycin (SM) and ethambutol (EMB) in first-line anti-tuberculosis drugs were analyzed. Results: The drug resistance rates of 504 MTB strains to the 4 kinds of the first-line anti-tuberculosis drugs from high to low were INH (17.26%), SM (15.67%), RFP (13.69%), EMB (5.16%). The drug resistance rates of MTB to INH, RFP and EMB in re-treated patients were 24.60%, 23.81% and 11.11%, respectively, which were significantly higher than those in newly treated patients (14.81%, 10.32%, 3.17%) (P<0.05). The drug resistance rates of 3 and 4 kinds of the first-line anti-tuberculosis drugs in retreated patients (9.52%, 7.14%) were significantly higher than those in newly treated patients (2.65%, 2.65%) (P<0.05). The rates of momo-resistance, poly-resistance and multidrug-resistance of 504 strains of MTB were 11.31%, 11.31% and 2.98%, respectively. The multi-drug resistance rate (20.63%) in the retreated patients was significantly higher than that in the newly treated patients (8.20%, P<0.05), and the resistance rate of INH+RFP+EMB and INH+RFP+SM+EMB in the retreated patients were significantly higher than that in the newly treated patients (P<0.05). Conclusion: The multi-drug resistance of MTB anti-tuberculosis drugs is serious in patients with re-treated tuberculosis in Xiamen area, which should be paid great attention in clinic.
  • Rational Evaluation of Nicordil Injection in 243 Patients with Cardiovascular Disease
    XU Sheng, TIAN Xia, TANG Hui
    2021, 18(8): 1102-1106. https://doi.org/10.13493/j.issn.1672-7878.2021.08-005
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To evaluate the clinical medications of nicorandil for injection in in-patients with cardiovascular diseases and to provide reference for regulating its rational usage. Methods: The hospital information system (HIS) was used to select 243 patients who were discharged on 11th to 20th of each month from January 2019 to June 2020 for retrospective analysis, and the rationality of clinical medications of nicorandil for injection in terms of indication, usage and dosage, medication course, drug combination, drug contraindication and adverse drug reactions were evaluated. Results: In 243 inpatients with cardiovascular diseases, 44 cases (18.11%) were completely reasonable in the use of nicorandil for injection, 108 cases (44.44%) were unsuitable, 125 cases (51.44%) were older in the course of medication, and 26 cases (10.70%) were unsuitable in combination with nicorandil for injection. There were 8 cases with contraindication (3.29%), and 45 cases with suspected adverse reactions (18.52%) during medication. Conclusion: Overuse of nicardil for injection in inpatients with cardiovascular diseases is a phenomenon. Clinically, indications of nicardil for injection should be strictly controlled, usage and dosage, medication course and contraband of nicorandil should be regulated, and empirical overuse should be avoided so as to ensure the safety and effectiveness of medication.
  • Analysis of Pathogens' Distribution and Drug Resistance of 102 Children with Severe Bacterial Pneumonia in a Hospital
    ZHU Jun-min, LI Ning
    2021, 18(8): 1107-1110. https://doi.org/10.13493/j.issn.1672-7878.2021.08-006
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To explore the pathogens' distribution and drug resistance of 102 children with severe bacterial pneumonia in a hospital, and to provide reference for the clinical treatment of severe pneumonia. Methods: 102 children with severe bacterial pneumonia admitted to hospital from June 2019 to June 2020 were selected as the research subjects. Lower respiratory tract secretions and 2 mL venous blood were collected within 24 hours of their diagnosis of severe pneumonia for bacterial culture and drug sensitivity test. The source and distribution of pathogenic bacteria of the patients were counted. The drug resistance of the main gram-negative bacteria and the main gram-positive bacteria was analyzed. Results: 151 strains of pathogenic bacteria were detected in 102 children with severe bacterial pneumonia, among whom 112 strains were detected in sputum(accounting for 74.17%), 73 strains were detected in blood(accounting for 48.34%). A total of 92 Gram-negative and 59 Gram-positive strains were isolated from 151 pathogenic bacteria, accounting for 60.93% and 39.07%, respectively. Among gram-negative bacteria, 36 strains of Klebsiella pneumoniae(23.84%), 18 strains of Escherichia coli(11.92%) and 12 strains of Acinetobacter baumannii(7.95%) accounted for the Top 3 proportion, respectively. The Top 3 proportion of gram-positive bacteria were 23 strains of Streptococcus pneumoniae(15.23%), 16 strains of Staphylococcus aureus(10.60%) and 12 strains of Hemolytic Streptococcus(7.95%), respectively. The results of drug sensitivity showed that the resistance rate of Gram-negative bacteria to imipenem and amikacin was low. The drug resistance rate of Klebsiella pneumoniae and Escherichia coli to ciprofloxacin was low. The resistance rate of Gram-positive bacteria to linezolid and vancomycin was low. Conclusion: Gram-negative bacteria were the main pathogens of severe bacterial pneumonia in children, and Klebsiella pneumoniae was the most common. Pathogenic bacteria were found to be resistant to common antibacterial drugs, and the appropriate drug use plan should be made based on the results of drug sensitivity test in clinical practice.
  • Analysis of Drug Resistance of Staphylococcus Aureus Isolated from Different Specimens to 12 Kinds of Commonly Used Anti-microbial Agents
    WANG Mei-ying
    2021, 18(8): 1110-1113. https://doi.org/10.13493/j.issn.1672-7878.2021.08-007
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the drug resistance of Staphylococcus aureus (SA) isolated from different specimens to 12 commonly used antibacterials in clinic. Methods: A total of 108 strains of SA were selected from various clinical specimens submitted to the hospital from January 2018 to October 2019 to analyze the characteristics of resistance of pathogens in different parts to commonly used antibacterial agents. Results: Of the 108 strains isolated from the SAU, 84 were methicillin-sensitive Staphylococcus aureus (MSSA) and 24 were methicillin-resistant Staphylococcus aureus (MRSA). It was mainly derived from secretions (62 strains, 57.41%), sputum (18 strains, 16.67%), blood (12 strains, 11.11%) and other specimens (16 strains, 14.81%). The results of drug sensitivity showed that the resistance rates of SAU to penicillin G, ampicillin and clindamycin were all high in these four types of specimens, while the sensitivity rates of vancomycin to them were all up to 100.00%. Conclusion: The SA isolated from hospital clinical specimens had a high resistance rate to commonly used antibacterial agents, some of them reached 100.00%, while the resistance rates to vancomycin, quinopudin-dafopudine, teicoplanin, and linezolid were low. Therefore, antibacterial agents can be selected rationally in clinical practice based on their drug sensitivity results to ensure their killing effect on MRSA and MSSA.
  • Analysis of Distribution and Drug Resistance of Pathogenic Bacteria in Specimens of 159 Lung Cancer Patients with Pulmonary Infection after Chemotherapy
    ZHU Ze-wen
    2021, 18(8): 1114-1117. https://doi.org/10.13493/j.issn.1672-7878.2021.08-008
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the clinical distribution of pathogenic bacteria in sputum specimens of lung cancer patients after chemotherapy and their resistance to antibacterial agents. Methods: Medical records of 159 cases of lung cancer patients treated in our hospital from January 2018 to August 2020 with pulmonary infection after chemotherapy were selected. The bacterial culture and drug sensitivity test results of sputum specimens in deep respiratory tract were statistically analyzed, and the distribution of pathogenic bacteria and the drug resistance characteristics of main pathogenic bacteria were analyzed. Results: 202 strains of pathogenic bacteria were isolated from the lung infection samples of 159 lung cancer patients after chemotherapy, including 56 strains (27.72%) of Gram-positive bacteria, 114 strains (56.44%) of Gram-negative bacteria and 32 strains (15.84%) of fungi. In the Gram-positive bacteria, Staphylococcus aureus showed higher resistance rates to penicillin and clindamycin, while the resistance rates to levofloxacin, compound sulfamethoxazole and moxifloxacin were lower. Enterococcus faecalis showed higher resistance rates to penicillin, clindamycin and gentamicin, while the resistance rates to compound sulfamethoxazole were lower. The drug resistance rates of Coagulase-negative Staphylococcus to penicillin, clindamycin and gentamicin were higher, while the drug resistance rates to oxacillin and compound sulfamethoxazole were lower, and no drug resistance to vancomycin was found. In the Gram-negative bacteria, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli had higher drug resistance rates to ampicillin, cefoperazone and cefazolin, but lower drug resistance rates to amikacin and imipenem. The resistance rate of Candida albicans to all antifungal agents was low. Conclusion: The main pathogens of pulmonary infection in lung cancer patients after chemotherapy were Gram-negative bacteria, but the drug resistance rate of each pathogen was different. Therefore, clinical use of antibacterials with high sensitivity rate should be reasonable based on the drug sensitivity results to ensure the progress of chemotherapy in lung cancer patients.
  • Influence of Pathogens' Drug Sensitivity and Special Nursing Intervention on Clinical Medication in 90 Elderly Patients with CAP
    LAI Wen-ting
    2021, 18(8): 1118-1121. https://doi.org/10.13493/j.issn.1672-7878.2021.08-009
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To explore the influence of the pathogens' drug sensitivity and special nursing intervention on clinical medication in elderly patients with community-acquired pneumonia (CAP). Methods: The medical records of 90 elderly CAP patients admitted to our hospital from November 2019 to November 2020 were selected to analyze the pathogenic bacteria culture and drug sensitivity results of sputum samples of CAP patients after admission, as well as the guiding value of special nursing intervention for clinical drug use. Results: 132 strains of pathogenic bacteria were isolated from 90 samples of elderly CAP patients, among whom 104 strains of Gram-negative bacteria accounted for 78.79%, 18 strains of Gram-positive bacteria accounted for 13.64% and 10 strains of fungi accounted for 7.57%. Pseudomonas aeruginosa and Klebsiella pneumoniae were the main strains of Gram-negative bacteria, while Streptococcus pneumoniae were the main strains of Gram-positive bacteria. The drug susceptibility test results showed that the drug resistance rates of Pseudomonas aeruginosa to ampicillin-sulbactam and gentamicin were 77.78% and 51.11%, respectively, while the drug resistance rates of Klebsiella pneumoniae to ampicillin-sulbactam were more than 54%. The resistance rates of Streptococcus pneumoniae to ciprofloxacin and penicillin were 90.00% and 50.00%, respectively. Conclusion: Gram-negative bacilli were the main pathogenic bacteria in elderly CAP patients, and drug resistance rate of isolated bacteria was high. Therefore, special nursing intervention should be strengthened in clinical practice, the distribution of pathogenic bacteria and changes in drug resistance should be monitored regularly, and antibacterials should be used scientifically and rationally.
  • Analysis of Pathogens' Distribution and Drug Resistance of Pulmonary Infection Caused by Radio-chemo-therapy in 124 Patients with Lung Cancer*1
    LIU Zhi-hui, ZHANG Guo-zheng
    2021, 18(8): 1122-1126. https://doi.org/10.13493/j.issn.1672-7878.2021.08-010
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the distribution and drug resistance of pathogenic bacteria in lung cancer patients with lung infection after radio-chemo-therapy, and provide reference for rational drug use to prevent pulmonary infection after radio-chemo-therapy. Methods: Medical records of 124 patients with lung cancer admitted to our hospital from January 2016 to December 2019 were selected to compare and analyze the results of pathogenic bacterial infection and antibacterial resistance before and after receiving radio-chemo-therapy. Results: Of the 124 patients, pulmonary infection occurred in 81 patients (65.32%) before radio-chemo-therapy, and in 103 patients (83.06%) after radio-chemo-therapy, 93 strains of pathogenic bacteria (including 58 Gram-negative bacteria, 14 Gram-positive bacteria and 21 fungi) were cultured from 81 patients before radio-chemo-therapy, and 119 strains of pathogenic bacteria (including 65 Gram-negative bacteria, 19 Gram-positive bacteria and 35 fungi) were cultured from 103 patients after radio-chemo-therapy. The drug susceptibility results showed that the resistance rates of Staphylococcus aureus and Staphylococcus epidermidis to penicillin, amoxicillin and ceftriaxone were high before and after radio-chemo-therapy, while no resistance to vancomycin was found. After radio-chemo-therapy, Pseudomonas aeruginosa and Escherichia coli in the Gram-negative bacteria showed low drug resistance to meropenem, and the drug resistance rate to imipenem was higher than 33%, and the drug resistance rates of fungi to antifungal agents were also relatively high. Conclusion: Lung cancer patients after radio-chemo-therapy led to low immunity, easy to develop pulmonary infection, especially fungal infection was more prominent. The distribution and drug resistance of pathogenic bacteria should be monitored in time during clinical radio-chemo-therapy.
  • Influence of Antibiotics Use Density of Carbapenems on Drug Resistance of Main Gram-negative Bacteria in a Hospital from 2015 to 2019*1
    ZHANG Li-fang, SHEN Min-feng, SONG Qiu-ping, QIAN Dong-lin
    2021, 18(8): 1127-1130. https://doi.org/10.13493/j.issn.1672-7878.2021.08-011
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To explore the influence of the antibiotics use density (AUD) of carbapenems on the drug resistance of common Gram-negative bacilli in clinical use, so as to provide reference for rational usage of carbapenems in clinic. Methods: Medical records of carbapenems antibacterials used by inpatients in the hospital from 2015 to 2019 were collected to analyze the drug resistance of AUD of carbapenems and major Gram-negative bacilli to carbapenems antibacterials. Results: From 2015 to 2019, AUD of clinical carbapenems were 785.01, 840.65, 888.32, 753.79 and 880.83 g/(100 persons·d), respectively. Drug sensitivity results showed that there was a strong positive correlation between drug resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannii and AUD of carbapenems in each season (r=0.430 and 0.514, P<0.05). Conclusion: Carbapenems antibacterial usage and detection of Gram-negative bacillus on carbapenems antibacterial drug resistance, there was a correlation between clinical should strengthen the management of antibacterial drug use, especially to strengthen the use of carbapenems antibacterial drug management, to improve the rationality of drug use, or avoid the generation of drug-resistant strains.
  • Analysis of Colonization and Drug-resistant Characteristics of Methicillin-resistant Staphylococcus aureus in Nasal Cavity of 150 Medical Staff in a Hospital*1
    BAI Yan, WU Bo
    2021, 18(8): 1131-1134. https://doi.org/10.13493/j.issn.1672-7878.2021.08-012
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To investigate the colonization and drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) in nasal cavity of hospital medical staff. Methods: Culture results of 150 nasal vestibular secretion specimens of 150 healthy medical staff (60 physicians and 90 nurses) were collected from June to December 2019, and the genotype of staphylococcal cassette chromosome (SCC) mec and drug resistance of MRSA were analyzed. Results: 17 strains of MRSA were isolated from 150 nasal vestibular secretion specimens, and the detection rate was 11.33%. The SCC mec genotypes of 17 strains of MRSA were identified, including 10 strains of type Ⅱ (58.82%), 5 strains of type Ⅲ (29.41%) and 2 strains of type Ⅳ (11.76%). The drug resistance rate of MRSA to penicillin was 100.00%, while the drug resistance rate to linezole, vancomycin, tigecycline was 0.00%. Conclusion: The detection rate of MRSA is at a high level in nasal vestibular secretion specimens of medical staff, and the different SCC mec genotypes are detected, to which the administrative department should pay great attention.
  • Analysis of Pathogens' Distribution and Changes of PCT, hs-CRP, IL-6 and IL-2 in 284 Patients with Postoperative Incision Infection after Gastrointestinal Surgery*1
    LI Jin-feng, SONG Zhen-zhen, LIU Bing
    2021, 18(8): 1212-1215. https://doi.org/10.13493/j.issn.1672-7878.2021.08-037
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the characteristics of pathogen distribution of postoperative incision infection in patients undergoing gastrointestinal surgery and the influence of serum PCT, hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and interleukin-2 (IL-2) levels on infection. Methods: Clinical data of 284 patients undergoing gastrointestinal surgery admitted to our hospital from January 2018 to December 2019 were selected and divided into infected group (n=29) and uninfected group (n=255) based on the infection status of surgical incision. The characteristics of pathogenic bacteria in the tissue fluid of incision at 48 h after operation were analyzed and compared, and the prediction efficacy of the changes in the levels of PCT, hs-CRP, IL-6 and IL-2 on postoperative incision infection were compared. Results: 43 strains of pathogenic bacteria were isolated from 284 gastrointestinal surgery patients, among whom 21 strains of Gram-negative bacteria (mainly Pseudomonas aeruginosa) accounted for 48.84%, 17 strains of Gram-positive bacteria (mainly Staphylococcus aureus) accounted for 39.53%, and 5 strains of fungi accounted for 11.63%. At 48 h after operation, the levels of PCT, hs-CRP, IL-6 and IL-2 in infected group were significantly higher than those in uninfected group (P< 0.05). The AUC of the above indexes used ROC curve to predict incision infection were 0.836, 0.788, 0.925 and 0.780, respectively, and the specificity was 79.31%, 58.62%, 89.66% and 65.52%, respectively. Conclusion: Pathogenic bacteria causing postoperative incision infection in patients with gastrointestinal diseases present diversified distribution, and the prediction of the level of early inflammatory factors can effectively distinguish the incidence probability of incision infection, so the risk of postoperative infection should not be underestimated, and special attention should be paid to it.
  • Analysis on Related Factors of 200 Case Report of Adverse Drug Reactions to Antibacterials in a Hospital from 2017 to 2020
    YIN Xiang-ge
    2021, 18(8): 1219-1223. https://doi.org/10.13493/j.issn.1672-7878.2021.08-039
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To analyze the characteristics and rules of adverse drug reactions (ADRs) of antibacterials in hospital, and to provide reference for rational drug use in clinic. Methods: Data of 200 cases of ADRs reported by hospitals from 2017 to 2020 were collected, and related factors such as patient age, gender, department distribution, drug use method, drug type, clinical manifestations of ADRs and their occurrence characteristics were analyzed. Results: In the 200 cases of ADRs reported, elderly patients accounted for the highest proportion (62 cases, 31.00%), the incidence of female was higher than that of male (56.00% vs 44.00%), and the proportion of nurses was higher than that of other occupations (84 cases, 42.00%). Intravenous infusion was the main method of administration (116 cases, 58.00%), quinolone was the main drug type (80 cases, 40.00%), and skin symptoms were the main clinical manifestations (92 cases, 46.00%), In which 2 patients died (2.00%). Conclusion: In the clinical medication of antibacterials,the great attention should be paid to the safety management of multiple medication of antibacterials in the elderly, and the clinical usage of antibacterials should be standardized to ensure the safety and rationality of patients' usage of antibacterials.
  • Influence of PDCA-SDCA Cycle Management Method on Improving the Quality and Quality Control Index of HAD Management in Hospital
    CHEN Huan
    2021, 18(8): 1230-1235. https://doi.org/10.13493/j.issn.1672-7878.2021.08-042
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective: To explore the role of PDCA-SDCA cycle in the management of high-alarm drugs (HAD) in our hospital in order to standardize the management of HAD and on improve medication safety. Methods: Firstly, the PDCA cycle was used to create the HAD management mode, and the differences of HAD management indicators before and after the implementation of the HAD management mode were compared. SDCA cycles were used to compare the effects before and after the activity. Results: The qualified rate of HAD-related knowledge assessment of front-line medical staff was increased from 67.00% to 88.00%; Pharmacists were fully involved in the management of self-prepared drugs, which was promoted from 2 to 3 links. The qualified rate of high alarm drug management in the pharmacy was increased from 60.00% to 92.00%; The qualified rate of high alarm drug management outside the pharmacy was increased from 51.00% to 83.00%. As a quality control indicator of the hospital, the qualified rate of high alarm drug management outside the pharmacy has been maintained between the range of 84.09% and 95.45% during SDCA cycle. Conclusion: The implementation of PDCA cycle effectively created the HAD management mode and improved the management level of HAD, while the implementation of SDCA cycle effectively improved the management quality and quality control indicators. The combination of PDCA-SDCA cycle in the quality control circle promoted the steady operation of quality improvement, and its effect was significantly improved.