KANGGANRAN YAOXUE

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  • 2021 Volume 18 Issue 9
    Published: 25 September 2021
      
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  • Research Progress in Anti-coccus Effects of Magnoliae Officinalis Cortex, Magnolol and Honokiol on Various Coccus in vitro
    ZHANG Ming-fa, SHEN Ya-qin
    2021, 18(9): 1241-1244. https://doi.org/10.13493/j.issn.1672-7878.2021.09-001
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    The crude extracts of Magnoliae Officinalis Cortex in different solvents have the pharmacological effects in vitro, among which petroleum ether and ethanol extracts have the strongest effects. Magnolol and honokiol are principal active components against coccus of Magnoliae Officinalis Cortex. The effect of magnolol seems stronger than honokiol. Magnolol and honokiol inhibit the expression of hemolytic enzyme, α-hemolysin, enterotoxin-A and enterotoxin-B in Staphylococcus aureus to block autolysis, and to decrease adhesiveness and virulence of Staphylococcus aureus, so blocking coccobacteria-induced inflammatory injury on host cell. Magnolol and honokiol inhibit Staphylococcus aureus of bacterial biofilm to synthesize and secrete eDNA and PIA, and to inhibit formation of bacterial biofilm, so decreasing self-protective ability of coccus to product effect of anti-coccus. In this paper, the pharmacological effects of magnolia officinalis and its components, magnolol and honokiol, against various coccus in vitro have been reviewed, and the research progress has been analyzed.
  • Determination of Palladium in Valaciclovir Hydrochloride by Inductively Coupled Plasma Atomic Emission Spectrometry
    TU Zhe-wei, WU Yang, LIN Cheng-xiang
    2021, 18(9): 1249-1253. https://doi.org/10.13493/j.issn.1672-7878.2021.09-003
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    Objective: To establish a method for the determination of palladium in valaciclovir hydrochloride by inductively coupled plasma atomic emission spectrometry (ICP-OES). Methods: Valaciclovir hydrochloride was directly dissolved in 0.5% nitric acid solution. Radio-frequency power was 1 300 W while plasma flow rate was 15 L/min, and nebulizer flow rate was set at 0.55 L/min. The analytical line of palladium was 340.458 nm. The developed method was subsequently validated according to the "Chinese Pharmacopoeia" 2020 edition. Results: There was a good linear relationship between palladium concentration and emission intensity in the range (0~0.5 μg/mL, r=0.999 9). The detection limit was 0.21 μg/g while the quantification limit was 0.70 μg/g. The accuracy of the method was 97.50% ~ 103.13% (n=6) and the precision was 1.69% (n=6). The residual contents of palladium in samples from 6 batches were between 2.97 μg/g and 5.73 μg/g. Conclusion: The method was proved to be simple, reproducible, sensitive, accurate and reliable. It is suitable for the determination of palladium in valaciclovir hydrochloride.
  • Analysis of Causes of Irrational Drug Use in 4 847 Outpatient Prescription and Intervention Effect of Pharmacists' Comment in a Hospital from 2018 to 2019
    YANG Guo-ying, HE Pei-hua, FENG Jian-chao, ZHENG Xiao-yong
    2021, 18(9): 1254-1256. https://doi.org/10.13493/j.issn.1672-7878.2021.09-004
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    Objective: To analyze the rationality of medications, types and manifestations of irrational drug use in out-patient department of hospital, and the effect of pharmacists' intervention. Methods: A total of 4 847 out-patient prescriptions from January 2018 to December 2019 were selected as analysis data, and the rationality of medication, types and manifestations of irrational drug use in out-patient prescriptions were reviewed, as well as the effect of pharmacists' prescription comment intervention. Results: Among the 4 847 out-patient prescriptions, 152 were irrational prescriptions, accounting for 3.14%, in which 79 were irrational prescriptions in 2018, accounting for 51.97%, and 73 were irrational prescriptions in 2019, accounting for 48.03%. There was no statistical significance in the qualified rate of prescriptions in 2018 (96.71%) compared with that in 2019 (97.02%) (P>0.05). In the TOP 3 reasons of irrational prescriptions in out-patient department in two years, inappropriate drug combination and inappropriate usage and dosage accounted for 22.37% and 20.39%, respectively. In 2019, the TOP 3 problems of unreasonable prescriptions found after the implementation of pharmacists' outpatient prescriptions review were inappropriate indications, inappropriate usage and dosage, and inappropriate drug combination, accounting for 30.14%, 26.03% and 23.29%, respectively. Conclusion: The qualified rate of outpatient prescriptions in 2019 is slightly higher than that in 2018, but the most common types of unreasonable reasons are still unsuitable indication, unsuitable usage and dosage, and unsuitable drug combination. The hospital should strengthen pharmacists' intervention for prescription comment, in order to improve the rationality of the out-patient medicine, and avoid or reduce the occurrence of unreasonable drug use or abuse.
  • Analysis of Distribution and Drug Resistance of 217 Strains of Carbapenem-resistant Enterobacteriaceae in Neonates*1
    LU Ke-li
    2021, 18(9): 1257-1260. https://doi.org/10.13493/j.issn.1672-7878.2021.09-005
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    Objective: To explore the distribution characteristics and drug resistance of carbapenam-resistant Enterobacteriaceae in neonates. Methods: The medical records of 90 neonates with bacterial infection admitted to the pediatrics department of our hospital from March 2018 to June 2020 were selected. The results of bacterial culture and identification in blood, urine, sputum, secretions and other samples were analyzed, and the distribution characteristics of carbapenem-resistant Enterobacteriaceae and the nosocomial infections were analyzed. The influence of carbapenem-resistant Enterobacteriaceae bacteria on the clinical treatment of common antibacterials was studied. Results: 217 strains of Enterobacteriaceae were isolated from the samples of 90 neonates infected with bacteria. The TOP 5 pathogens were Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus singular and Enterobacter aerogenes. In them, 11 strains of carbapenem-resistant Enterobacteriaceae (1 strain of Escherichia coli, 6 strains of Klebsiella pneumoniae and 4 strains of Enterobacter cloacae) were isolated. Carbapenem-resistant Enterobacteriaceae were mainly colonized in neonatal pneumonia, respiratory distress syndrome, wet lung, sepsis, hyperbilirubinemia and other clinical infections. Carbapenem-resistant Enterobacteriaceae were mainly isolated from blood, urine, sputum, secretions and other specimens. Carbapenem-resistant Enterobacteriaceae were mainly resistant to imipenem (100.00%), ampicillin (81.82%), piperacillin and meropenem (72.73%), aztreonam (63.64%), piperacillin and ceftazidime (54.55%). Conclusion: The clinical infection rate of carbapenem-resistant Enterobacteriaceae in neonates was high, in which the majority were Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae, which were resistant to a variety of antibacterial agents, but the sensitivity rate of amikacin was high.
  • Analysis of Distribution and Drug Resistance of Main Pathogens in 74 Patients with Respiratory Failure Complicated and Pulmonary infection
    LIANG Yan
    2021, 18(9): 1261-1264. https://doi.org/10.13493/j.issn.1672-7878.2021.09-006
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    Objective: To analyze the distribution and the characteristics of drug resistance of pathogenic bacteria in respiratory failure patients with pulmonary infection. Methods: The medical records of 74 patients with respiratory failure complicated with pulmonary infection admitted to the geriatric department of the hospital from December 2019 to December 2020 were selected. The results of pathogenic bacteria culture and drug sensitivity in sputum specimens of the patients were statistically analyzed, and the distribution characteristics of pathogenic bacteria and the characteristics of drug resistance of gram-negative bacteria were analyzed. Results: 82 strains of pathogenic bacteria were detected in 74 patients with pulmonary infection, 57 strains in patients with ventilators associated pneumonia (VAP) and 25 strains in patients with non-VAP. In them, 69 strains of Gram-negative bacteria accounted for 84.15% (mainly Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae), 13 strains of Gram-positive bacteria accounted for 15.85%. Drug sensitivity results showed that Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae had high drug resistance rate to Gentamicin, ceftriaxone, cefoperazone, compound sulfamethoxazole, imipenem and other commonly used antibacterials in the major Gram-negative bacteria. Acinetobacter baumannii was highly resistant to antibacterials except minocycline. Conclusion: The common pathogenic bacteria associated with pulmonary infection in patients with respiratory failure were Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, which had high drug resistance rate to commonly used antibacterial drugs. Therefore, antibacterials with high sensitivity rate should be selected for clinical treatment based on the distribution characteristics of pathogenic bacteria and drug sensitivity results.
  • Analysis of Related Indicators of Imipenem-cilastatin's Clinical Medication in 387 Cases in a Hospital and Its Reasons for Irrational Drug Usage*1
    DING Xiao-lan, NI Chun-yan
    2021, 18(9): 1265-1268. https://doi.org/10.13493/j.issn.1672-7878.2021.09-007
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    Objective: To analyze the rationality and unreasonable reasons of clinical medication of imipenem-cilastatin sodium in a hospital. Methods: The medical records of 387 patients treated with imipenem/cisastatin for injection from October to December 2019 in the hospital were selected to analyze the rationality and unreasonable reasons of the relevant indicators of the clinical medication of imipenem/cisastatin. Results: Among 387 cases of patients treated with imipenem/cisastatin for injection,59 cases （15.24%） were unsuitable. In the TOP 6 departments with the use of imipenem/cisastatin,256 patients received imipenem/cisastatin,accounting for 66.15%. The microbial test rate was 29.46% before treatment and 51.94% after treatment. The combined medication of antibacterials was mainly in the form of 2 kinds of drug combinations. 75 cases （19.38%） had adverse drug reactions （mainly rash and pruritus）. Conclusions: The usage of imipenem/cisastatin for injection in hospital still exists unreasonable phenomenon,the administrative department of hospital should strengthen the education and management of rational drug use knowledge to promote rational drug use in clinic.
  • Analysis of Seasonal, Occupational Distribution and Drug Resistance of 1 842 Patients with Helicobacter Pylori Infection in a Hospital
    CHEN Shao-yi
    2021, 18(9): 1269-1272. https://doi.org/10.13493/j.issn.1672-7878.2021.09-008
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    Objective: To study the seasonal, occupational distribution and drug resistance of 1 842 patients with Helicobacter Pylori (Hp) infection in a hospital, and to provide reference for rational drug usage in clinic. Methods: 1 842 patients with Hp infection in a hospital from January 2017 to December 2020 were selected as the research objects. Descriptive epidemiological methods were used to analyze the epidemic characteristics of patients, and plate incorporation method was used to complete the analysis of Hp drug resistance. Corresponding intervention measures were taken based on the drug resistance rate. Results: 1 842 patients with Hp infection in a hospital were tested for pathogenic bacteria. 1 802 positive cases of effective Hp infection were obtained through matching, and the effective rate was 97.83%. Statistical analysis of relevant data was completed for all the Hp positive patients. The results of time distribution showed that the Hp positive patients were distributed throughout the year, with 804 cases (44.62%) mainly distributed in June to August. The occupational distribution of Hp infection was wide, the top three were: housework, farmers and individual, business and enterprise service personnel, accounting for 15.65%, 10.77% and 10.54% respectively; the drug resistance rate of Hp positive patients in a hospital was analyzed, and the results showed that the top three drug resistance rates of Hp were metronidazole, clarithromycin and levofloxacin, and the drug resistance rates were 95.12%, 19.98% and 19.75% respectively. Conclusions: Hp positive patients in a hospital are widely distributed, who are mainly in rural towns and streets, relatively high education level of the population. Hp hads a high rate of drug resistance to commonly used antibacterials in clinic, so the analysis of drug resistance has to be strengthened and sensitive antibacterials should be selected for treatment.
  • Analysis of Distribution and Drug resistance of Fungi Detected in 312 Patients with Fungal Sinusitis
    QIU Ya-shuang
    2021, 18(9): 1273-1275. https://doi.org/10.13493/j.issn.1672-7878.2021.09-009
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    Objective: To analyze the distribution and drug resistance of fungus detected in 312 patients with fungal sinusitis. Methods: 312 cases of patients with fungal sinusitis admitted to our hospital from September 2019 to September 2020 were selected as the research objects. Pus specimens were collected during nasal endoscopy for fungal culture and drug sensitivity test, and the distribution of fungi in patients of different ages, the distribution of 348 strains of fungi and the drug resistance of common fungi were analyzed. Results: 348 strains of fungi were detected in 312 pus samples, including 28 strains(8.05%) in patients aged 1 to 18 years, 93 strains (26.72%)in patients aged 18 to 40 years, 185 strains (53.16%) in patients aged 41 to 60 years and 42 strains(12.07%) in patients over 60 years. In the 348 fungal strains, 135 strains were Aspergillus(38.79%), 87 strains were Aspergillus fumigatus(25.00%), and 22 strains were Scedosporium apiospermum(6.32%). The drug resistance rates of common fungi to voriconazole, ketoconazole, miconazole, fluorocytosine and nystatin were high, and the drug resistance rates to amphotericin B, itraconazole, micafungin and anidulafungin were low. Conclusion: The middle-aged and young people are the main population of fungal sinusitis, and most of the fungi are Aspergillus. In clinical practice, doctors should rationally select antifungal drugs based on the specific conditions of patients of different ages, fungal culture and drug sensitivity test results, so as to reduce the occurrence of drug resistance.
  • Analysis of Distribution and Drug Resistance of Pathogenic Bacteria in Sputum Specimens of Pulmonary Tuberculosis Patients in a Hospital
    SHI Jing-ping
    2021, 18(9): 1276-1279. https://doi.org/10.13493/j.issn.1672-7878.2021.09-010
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    Objective: To analyze the distribution and drug resistance rate of pathogenic bacteria in sputum specimens of pulmonary tuberculosis patients in a hospital. Methods: 162 patients with pulmonary tuberculosis admitted on June 2018 to April 2020 in a hospital were collected as the research object, who were improved relevant checks after admission, and their morning sputum bacterial culture were collected based on the clinical microbiology test procedures for training and identification of infectious pathogens, to further determine pathogenic bacteria species and analyze drug resistance. Results: Sputum samples were collected from 162 patients, and 185 strains of pathogenic bacteria were isolated, including 102 strains of Gram-negative bacteria(55.14%), 71 strains of Gram-positive bacteria(38.38%) and 12 strains of fungi(6.49%). The gram-negative bacteria were mainly Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli, accounting for 18.92%, 13.51% and 11.35% respectively. The drug resistance rates of major gram-negative Escherichia coli were 85.71% and 61.90% respectively. The top 2 resistance rates drug of Klebsiella pneumoniae were penicillin and gentamicin, which were 91.43% and 85.71% respectively. The top 2 resistance rates drug of P. aeruginosa were piperacillin - tazobactam sodium and ceftazidime, which were 52.00% and 36.00% respectively. The top 2 resistance rate drug of the main Gram-positive bacteria Staphylococcus aureus were rifampin and penicillin, accounting for 71.88% and 62.50% respectively. The top 2 resistance rate antibacterials of Enterococcus faecalis were rifampin and erythromycin, accounting for 80.77% and 65.38% respectively. Conclusion: The infection rates of pathogenic bacteria in pulmonary tuberculosis patients in a hospital are high, most of the pathogenic bacteria are gram-negative bacteria, and the pathogenic bacteria have high drug resistance rate. Strengthening the analysis of pathogenic bacteria type, drug resistance and reasonable selection of antibacterial drugs is helpful to reduce the infection rate.
  • Analysis of Distribution and Drug Resistance of Pathogenic Bacteria in Blood Samples of 816 Neonates with Suspected Infection
    XIE Lan-fang
    2021, 18(9): 1280-1283. https://doi.org/10.13493/j.issn.1672-7878.2021.09-011
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    Objective: To study the distribution and drug resistance of pathogenic bacteria in blood culture of 816 neonates with suspected infection. Methods: Clinical data of 816 hospitalized neonates with suspected infection who underwent blood culture examination in Anyuan County People's Hospital from February 2018 to February 2020 were collected to analyze the distribution and drug resistance of pathogens. Results: A total of 209 strains of pathogenic bacteria were detected in 816 neonatal blood culture specimens, and the positive rate was 25.61%. 173 strains of Gram-positive bacteria accounted for 82.78%, in which coagulase-negative Staphylococcus accounted for the largest proportion, followed by Enterococcus. There were 36 strains of Gram-negative bacteria, accounting for 17.22%, in which Escherichia coli accounted for the largest proportion. The resistance rates of coagulase-negative Staphylococcus to penicillin G and oxacillin were high, but the drug resistance of Staphylococcus to naquinoputin/dapofuputin, tegacycline, linezolid and vancomycin were not detected. The drug resistance rate of major Gram-negative bacteria Escherichia coli to ampicillin, compound sulfamethoxazole and gentamicin were high, but no resistant strains to amikacin, cefepime, ceftazidime, cefotetan, tobramycin and imipenem were detected. Conclusion: The most common pathogens of neonatal sepsis is coagulase-negative Staphylococcus, which is resistant to common antibacterials. Clinicians should know the distribution and drug resistance of pathogenic bacteria on time so as to further improve the rationality of clinical drug usage.
  • Analysis of Distribution and Drug Resistance of Pathogenic Bacteria of Respiratory Tract Infection Elderly Patients with Lung Cancer
    CHEN Zhong, SHANG An-quan, ZHANG Ya-feng, HU Peng-yu, GU Jun-xing
    2021, 18(9): 1284-1286. https://doi.org/10.13493/j.issn.1672-7878.2021.09-012
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    Objective: To analyze the distribution and drug resistance of pathogenic bacteria of respiratory tract infection elderly patients with lung cancer. Methods: 116 elderly lung cancer patients with respiratory tract infection admitted to the hospital from January 2018 to December 2020 were selected as the research objects. Sputum specimens were collected for bacterial and fungal culture as well as drug sensitivity test, and the distribution and drug resistance rate of pathogens of respiratory tract infection were analyzed. Results: 245 strains of pathogenic bacteria were isolated from 116 patients, in whom Gram-positive bacteria accounted for 28.98%(71/245), Gram-negative bacteria accounted for 60.00%(147/245), and fungi accounted for 11.02%(27/245). The main pathogens were Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii and Candida albicans. The resistance rate of Acinetobacter baumannii to cefoperazone sulbactam sodium were lower than 30.00%. The drug resistance rates of Klebsiella pneumoniae to amikacin, imipenem, cefoperazone sulbactam sodium and meropenem were lower than 30.00%. The resistance rates of Pseudomonas aeruginosa to meropenem, imipenem and amikacin were lower than 30.00%. The resistance rate of Staphylococcus aureus to vancomycin and linezolid were 0.00%. The resistance rate of Candida albicans to amphotericin B and voriconazole were 0.00%. Conclusion: Gram-negative bacteria are the main pathogens of respiratory tract infection in elderly patients with lung cancer, and appropriate antibacterial agents have to be selected based on drug sensitivity test results.
  • Analysis of Pathogen Distribution and Drug Resistance of Respiratory Tract Infection in Patients with Pulmonary Tuberculosis
    Chen Yin
    2021, 18(9): 1287-1290. https://doi.org/10.13493/j.issn.1672-7878.2021.09-013
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    Objective: To analyze the pathogen's distribution and drug resistance of pulmonary tuberculosis patients with respiratory tract infection. Methods: 128 cases of pulmonary tuberculosis patients treated in the hospital from August 2019 to August 2020 were selected, their sputum samples were collected for bacterial culture and drug sensitivity test, and the respiratory tract infection rate of 128 cases of pulmonary tuberculosis patients, the distribution of pathogenic bacteria detected in sputum samples of patients, and the drug resistance of main Gram-negative bacteria and Gram-positive bacteria were statistically analyzed. Results: In 128 cases of pulmonary tuberculosis, 72 cases were complicated with respiratory tract infection(the infection rate was 56.25%). A total of 114 strains of pathogenic bacteria were detected in 128 sputum samples, including 78 strains of Gram-negative bacteria(68.42%), 30 strains of Gram-positive bacteria(26.31%) and 6 strains of fungi(5.26%). The difference in the component ratio of the three pathogenic bacteria was statistically significant(P<0.05). The main Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae showed low drug resistance rates to cefepime, imipenem, aztreonam, cefoperazone, meropenem and amikacin, and their drug resistance rate to trimethoprim-sulfamethoxazole, levofloxacin and ampicillin was high. The main Gram-positive strains Staphylococcus epidermidis and Staphylococcus aureus showed low drug resistance rates to tigecycline, erythromycin, vancomycin and linezolid, and their drug resistance rate to penicillin G, oxacillin, levofloxacin and ciprofloxacin was high. Conclusions: Most of the pathogens of respiratory tract infection in patients with pulmonary tuberculosis are Gram-negative bacteria, which are characterized by high drug resistance rate and multi-drug resistance. Therefore, appropriate antibacterial agents have to be selected based on the results of drug sensitivity test.
  • Epidemiology and Serotype Distribution Characteristics of Haemophilus Influenzae Infection in 3 381 Children and Their Influence on Clinical Antimicrobial Medication
    YUAN Wen-qing, ZHAO Liang, CHA Ling, ZHU Chong-feng
    2021, 18(9): 1362-1365. https://doi.org/10.13493/j.issn.1672-7878.2021.09-035
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    Objective: To analyze the influence of epidemiology and serotype distribution characteristics of Haemophilus influenzae infection in children on clinical antibacterial medication. Methods: The data of 3 370 children with Haemophilus influenzae infection admitted to the hospital from January 2017 to December 2019 were selected. The age, sex, time of infection, regional distribution and the typing characteristics of Haemophilus influenzae were analyzed, and the effects of the isolation, identification and drug sensitivity test results on clinical treatment of Haemophilus influenzae were analyzed. Results: In the 3 370 children infected with Haemophilus influenzae, there was no significant difference in infection rate between different genders and different regions. The infected children were mainly ≤ 1 year old, and the infection season was mainly spring. 3 381 strains of Haemophilus influenzae were isolated from the specimens of these patients, including 1 825 non-typable strains (accounting for 53.98%) and 1 556 typable strains (accounting for 46.02%). In 1 556 typable strains, there were 507 strains of type A (accounting for 15.00%), 67 strains of type B (accounting for 1.98%), 202 strains of type C (accounting for 5.97%), 372 strains of type D (accounting for 11.00%), 136 strains of E type (accounting for 4.02%) and 272 strains of F type (accounting for 8.04%). The positive rate of β -lactamase in 3 381 strains of Haemophilus influenzae was 48.44%, and the drug resistance rates to compound sulfamethoxazole, ampicillin and ampicillin-sulbactam were 72.81%, 56.61% and 48.44%, respectively. But there was no resistance to meropenem, ceftazidime, cefotaxime and ceftriaxone (sensitivity rate up to 100.00%). Conclusion: Haemophilus influenzae infection age is less than 1 year old was the high incidence group, and the infection rate in spring is higher. The infection rate of untypable strains is more, followed by type A of separable strains. Moreover, Haemophilus influenzae has no drug resistance to meropenem, ceftazidime, cefotaxime and ceftriaxone,so antibcterials with high sensitivity rate could be selected for clinical treatment so as to ensure its antibacterial effect.
  • Clinical Analysis of 1 Case of Drug Fever Induced by Vancomycin after Hip Arthroplasty and Its Pharmaceutical Care
    YU Ji-shuang, LU Jin
    2021, 18(9): 1370-1373. https://doi.org/10.13493/j.issn.1672-7878.2021.09-037
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    Objective: To explore the clinical characteristics, differential diagnosis and treatment of drug fever induced by vancomycin, and to provide reference for rational drug use in clinic. Methods: The clinical pharmacist participated in the diagnosis and treatment process of a patient with fever after hip replacement, by searching literatures materials and combining with the patient's condition and laboratory examination results, the clinical pharmacist assisted clinicians in screening the causes offever and formulating treatment plans and pharmaceutical care. Results: Clinical pharmacists analyzed that the cause of the patient's fever was related to the therapeutic vancomycin, and suggested that vancomycin should be stopped on time. On the third day after vancomycin was stopped and imipenem-cilastatin sodium was used, the patient's temperature returned to normal. Conclusion: Clinical pharmacists actively participate in clinical diagnosis and treatment practice, give full play to their professional advantages in the monitoring of adverse drug reactions, diagnosis and prevention of drug-derived diseases, and help clinicians to formulate treatment plans, and further prove the safety and effectiveness of drug therapy.
  • Analysis of the Diagnosis, Treatment and Medication of a Patient with Invasive Pulmonary Aspergillus*1
    XIAO Shen-rong, WU Qing-rong
    2021, 18(9): 1374-1378. https://doi.org/10.13493/j.issn.1672-7878.2021.09-038
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    Objective: To analyze the diagnosis, treatment and medication of a patient with invasive pulmonary aspergillus participated by a clinical pharmacist, thus to provide reference for the formulation of anti-infection treatment plan of invasive pulmonary aspergillus. Methods: Clinical pharmacist participated in the diagnosis and drug treatment of a patient with invasive pulmonary aspergillus, who gave full play to his own advantages, so as to assist clinicians to formulate anti-infection treatment plan, and implement individualized monitoring throughout the whole process. Results: Clinical pharmacist assisted physicians to finally formulate the combination regimen of voriconazole and caspofunnet, which effectively controlled the infection symptoms of patient, and ensured the safety and effectiveness of treatment, in addition it had no adverse reactions. Conclusion: Clinical pharmacists have played a positive role in the diagnosis and treatment of patient, and ensured the rationality of patients' medication.
  • Recruitment and Hospitalization Management of Trial Subjects for Phase I Drug Clinical Trials during COVID-19 Outbreak
    GU Qin, ZHANG Yue-ling, ZHU Rui-fang, QI Hui-xin, JIANG Yi-guo
    2021, 18(9): 1383-1386. https://doi.org/10.13493/j.issn.1672-7878.2021.09-040
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    Objective: To explore the strategies for the recruitment and inpatient management of drug phase I clinical trials during the COVID-19 outbreak. Methods: The COVID-19 outbreak at the end of December 2019 had a huge impact on all sectors of the industry, and the implementation of drug clinical trials was also facing new challenges. As COVID-19 was gradually brought under control, the resumption of work and production was progressing steadily. It was very important to formulate a response strategy for conducting drug clinical trials under the influence of COVID-19. In order to carry out drug clinical trials in a stable and orderly manner and avoid the spread of COVID-19 when the COVID-19 outbreak was not completely over; The feasibility of subject recruitment and hospitalization management strategy was explored through the control measures of subject recruitment, protective material preparation, subject screening and other aspects of management. Results: The formulation of guidelines for the implementation of phase I clinical trials, the orderly development of phase I clinical trials were ensured. Conclusion: Establishing a scientific, standardized, timely and effective response mechanism for COVID-19 and clarifying comprehensive prevention and control strategies and measures are taken to the life safety of subjects, avoiding occupational exposure of medical staff and ensuring the safe and orderly conduct of drug clinical trials.