KANGGANRAN YAOXUE

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  • Research Advances in Pharmacokinetics of Sophocarpine and Oxysophocarpine
    ZHANG Ming-fa, SHEN Ya-qin
    2020, 17(4): 463-467. https://doi.org/10.13493/j.issn.1672-7878.2020.04-001
    Abstract ( 171 ) Download PDF ( 8 )   Knowledge map   Save
    Sophocarpine and oxysophocarpine are matrine-type alkaloids. Matrine-type alkaloids have a widespread bioactivities, including protection of heart, liver, lung, kidney, brain and blood vessel, and the effects of positive inotropism, negative chronotropism and antiarrhythmia on heart, as well as promoting leukocytes, antiasthma, antiulcer, anti-fibrogenesis in liver, and central suppression of sedation, hypnogenesis, analgesia, and antitumor, immunoregulation, anti-bacteria, anti-virus and anti-inflammation. The literatures of the pharmacokinetic parameters and process in body of sophocarpine and oxysophocarpine were reviewed, and their research advances on pharmacokinetics were analyzed, so as to provide a reference for rational usage of drugs.
  • Study on Esomeprazole Enteric Sustained Release Preparation Based on Consistency Evaluation
    GU Jia-yu, GUO Wen-xia, ZHANG Xue-nong
    2020, 17(4): 468-472. https://doi.org/10.13493/j.issn.1672-7878.2020.04-002
    Abstract ( 107 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To study the development of esomeprazole enteric sustained release preparation based on the same pharmaceutical evaluation. Methods: By analyzing the registration and public information of the original agent in different countries and evaluating the advantage, the doseage form suitable for commercial production and pharmacoeconomics were selected. With drug concentration in the drug layer, weight gain in the isolation layer and weight gain in the enteric layer as the selection factors, while stability and dissolution curve were used as evaluation indexes to screen the formula, we developed and validated the formulation. Results: The dosage form most suitable for commercial production is capsule. Tablet of coated pellets was one of the most difficult oral dosage form in commercial batch. For capsule, the drug concentration was 15.00% in core pills, weight gain was 1320% for isolation layer, and weight gain was 30.50% for enteric layer. Conclusion: The formulation and process are suitable for commercial production and pharmacoeconomics. The formulation process is feasible and repeatable, and the production is reliable.
  • Comparison of Antibacterial Effects of Extracts from Different Processed Products of Flos Chrysanthemi Indici on 5 Kinds of Pathogens*1
    HUANG Chun-hua, XIE Mei-qiang, WANG XIAO-ping, YANG Shi-chun
    2020, 17(4): 473-476. https://doi.org/10.13493/j.issn.1672-7878.2020.04-003
    Abstract ( 106 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To compare the bacteriostatic effects of extracts from different processed products of Flos Chrysanthemi Indici on 5 common bacteria (S. aureus, S. neumoniae, E. coli, S. castellani, and P.averuginosa). Methods: Different methods were used to extract different processed products of Flos Chrysanthemi Indici, and the minimum antimicrobial ring diameter of different processed products of Flos Chrysanthemi Indici was measured by microbiological test. The differences of the minimum inhibitory concentration and spatial inhibitory rate of extracts from different processed products of Chrysanthemum were compared. Results: The results of bacteriostatic experiment showed that the inhibitory effect of alcohol extract was better than that of steam products and dried products. The antibacterial effect of steamed products is better than that of dried ones. There was no significant difference among the three volatile oils in bacteriostatic circles. The results of the determination of the minimum inhibitory concentration showed that the minimum inhibitory concentration of the extracts of S. aureus and S. pneumoniae was lower than that of steamed products and dried products (P<0.05), but there was no statistical significance between the minimum inhibitory concentration of other bacteria (P>0.05). The results showed that the antibacterial activity of the alcohol extract was higher than that of the dried product (P<0.05). Conclusion: The antibacterial effect of extracts from different processed products of Chrysanthemum on 5 kinds of common bacteria is quite different, the effect of raw extracts is the best, the effect of alcohol extract from steamed products is the second, and the effect of alcohol extract from dried products is poor. Different processing methods have influence on the antibacterial activity of Chrysanthemum. The alcohol extract of raw products is better than that of steamed products.
  • Establishment of Dispensing Error Prevention System in Intelligent Pharmacy Based on Risk Management and Its Implementation
    XU Tao, CHEN Rong, WANG Wan-qing, TANG Jie
    2020, 17(4): 477-481. https://doi.org/10.13493/j.issn.1672-7878.2020.04-004
    Abstract ( 83 ) Download PDF ( 5 )   Knowledge map   Save
    Objective: Based on risk management, to establish the prevention system and application of major risk factors of dispensing errors preventive system in intelligent pharmacy, so as to reduce dispensing errors in the pharmacy. Methods: By identifying and evaluating the possible risk factors in pharmacy management, the risk management system of error prevention was constructed in personnel, equipment, software, prescription, personnel and environment, and based on the risk management the error has been effectively reduced. Results and Conclusion: Through constructing the risk control management system, establishing and perfecting the rules and regulations of the intelligent pharmacy, standardizing the personnel configuration and the management of pharmacy, and implementing the risk management of error prevention in all directions, it can effectively reduce the occurrence of errors in the intelligent pharmacy, standardize the work of the pharmacy, and reduce the contradiction between doctors and patients, so as to ensure the patient safety and rationality of drug use.
  • Analysis on Risk factors of Inducing Nosocomial Infection in Patients with Hypertensive Intracerebral Hemorrhage and its countermeasures
    LUO Yong-liang
    2020, 17(4): 545-548. https://doi.org/10.13493/j.issn.1672-7878.2020.04-027
    Abstract ( 93 ) Download PDF ( 11 )   Knowledge map   Save
    Objective: To analyze the risk factors of inducing nosocomial infection in patients with hypertensive cerebral hemorrhage. Methods: The clinical data of 271 patients with hypertensive intracerebral hemorrhage admitted for surgical treatment from February 2017 to October 2019 were retrospectively analyzed, the causes of postoperative nosocomial infection were statistically analyzed, and the prevention and treatment measures were proposed for the risk factors leading to nosocomial infection. Results: Among the 271 patients, the 66 patients of nosocomial infection were induced(24.35%), and the incidence of pulmonary infection accounted for 53.06%. Univariate and multivariate Logistic regression analysis showed that the incidence of nosocomial infection in patients with hypertensive cerebral hemorrhage was correlated with the patient's age (greater than or equal to 60 years), smoking history, white blood cell count (greater than or equal to 10×109/L), albumin level (less than 13 g/L), GCS score (less than 8 points), invasive operation and length of stay greater than or equal to 14 days (P<0.05), which were independent risk factors. Conclusion: There are many influencing factors of nosocomial infection in patients with hypertensive intracerebral hemorrhage after operation, so clinical attention should be paid to its influencing factors; prevention and treatment measures should be taken to reduce the occurrence of nosocomial infection and to ensure the safety of treatment in patients.
  • Influence of Strengthening Management of Infectious Specimens in Path-ology Department on Control of Nosocomial Infection and Its Measures
    XU Meng-meng, ZHANG Yong-sheng
    2020, 17(4): 549-552. https://doi.org/10.13493/j.issn.1672-7878.2020.04-028
    Abstract ( 97 ) Download PDF ( 9 )   Knowledge map   Save
    Objective: To explore the influence of strengthening the management of infectious specimens in the department of pathology on the control of nosocomial infection and its measures, and to provide reasonable suggestions and improvement methods for developing preventive measures against nosocomial infection caused by infectious specimens. Methods: By analyzing the pollution prevention and control points in the ways of receiving infectious specimens, the procedures of specimen treatment and the treatment of medical wastes in the department of pathology, and the links of nosocomial infection caused by infectious specimens were analyzed in detail, which provided a basis for exploring and establishing feasible improvement plans. Results: In management and execution, from hospitals, departments to responsible persons, there were weak links, so it was necessary to further strengthen the standardized management and improve the management measures of infectious specimens. Conclusion: It is urgent to establish and perfect the standard management system and operation regulations and to change the disposal procedure of infectious specimens so as to prevent and control nosocomial infection in the department of pathology.
  • Experience of Carrying Out Pharmaceutical Care as Starting Point in Primary Hospitals by Monitoring Adverse Drug Reactions
    WANG Hong-yuan, CHEN Xiao, XU Qiu-xiang
    2020, 17(4): 565-567. https://doi.org/10.13493/j.issn.1672-7878.2020.04-034
    Abstract ( 76 ) Download PDF ( 6 )   Knowledge map   Save
    Objective: To explore the content and methods of pharmaceutical care as the starting point in primary hospitals by monitoring adverse drug reactions. Methods: Based on the investigation and analysis of adverse reactions of clindamycin injection, the solving methods and interventions were put forward. Results: Through the implementation of relevant intervention measures, the adverse drug reactions of clindamycin injection were significantly reduced, and no serious cases were found. Conclusions: Taking the monitoring of adverse drug reactions as the entry point, clinical pharmacists' specialty in pharmacy was brought into full play in clinical practice. Actively communicate with doctors, nurses and patients and solve practical problems, promoting rational drug use. It is an effective way for clinical pharmacists in primary hospitals to change their working mode and carry out pharmaceutical care.
  • Influence of Combination by Cefazolin and Ornidazole on Preventing Incision Infection and Clearing Pathogen in Rectal Cancer Patients
    SUN Meng-zhe
    2020, 17(4): 570-573. https://doi.org/10.13493/j.issn.1672-7878.2020.04-036
    Abstract ( 93 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To study the efficacy of combination by cefazolin and ornidazole on preventing postoperative incision infection in rectal cancer patients and its influence on pathogen clearance. Methods: Data of 80 postoperative patients with rectal cancer admitted to the department of rectal medicine from May 2017 to September 2018 were selected, and the patients were divided into control group and observation group with different drugs to prevent postoperative infection, 40 cases in each group. Patients in the control group were given ornidazole to prevent postoperative infection, while patients in the observation group were given cefazolin sodium and ornidazole to prevent postoperative infection.The clinical efficacy and pathogen clearance rate of different drugs were compared between the two groups, also comparing the improvement of inflammatory indicators before and after prophylactic treatment. Results: The total effective rate of the observation group was significantly higher than that of the control group (90.00% vs 72.50%) (P<0.05), and the pathogen clearance rate was significantly higher than that of the control group (P<0.05). CRP, TNF-α and IL-6 were all lower in the observation group than in the control group (P<0.05). Conclusion: The combination of cefazolin sodium and ornidazole have a good effect in preventing postoperative incision infection in rectal cancer patients, effectively removing pathogenic bacteria, controlling the effect on inflammatory indicators, and improving the effect of postoperative incision infection prevention.
  • Analysis on Safety Precautions for Doctors, Nurses, and Patients against COVID-19 in Oncology and Hematology Department and Its Efficacy
    QIU Jun-lan, HE Su-mei, WANG Li-juan, FENG Lin
    2020, 17(4): 611-614. https://doi.org/10.13493/j.issn.1672-7878.2020.04-052
    Abstract ( 92 ) Download PDF ( 4 )   Knowledge map   Save
    Objective: To analyze the safety precautions and efficacy against Coronavirus disease (COVID-19) in Oncology and Hematology department, and to reduce the anxiety of patients in Oncology and Hematology Department, so as to better serve patients in Oncology and Hematology department. Methods: Information of 55 discharged patients and 30 medical staff of the department during the epidemic period (from January 20 to February 20, 2020) were selected. The implementation of preventive measures, proper wearing and removing of protective equipment, strict hand hygiene and observance of cough etiquette were analyzed. The medical safety quality index of 100 patients discharged in 2019 was compared in the same period. Results: There was no COVID-19 infection among doctors, nurses and patients during the epidemic period. The number of patients discharged from hospital, the average length of stay and the average hospitalization cost during the epidemic period were significantly reduced compared with the same period in 2019, and the difference was statistically significant (P<0.05). However, the difference between the rate of disease recovery and the incidence of complications was not statistically significant (P>0.05). Conclusion: The prevention and control measures of Oncology and Hematology Department were effectively implemented and prevented under the outbreak of COVID-19, which exempted the patients from anxiety.
  • The Medicine Management and Practice of the Designated Medical Institution in the Process of Fighting against COVID-19 : Taking the Fifth People's Hospital of Suzhou as an Example*1
    SONG Quan, PAN Yun-zhi, CHENG Jun-ping
    2020, 17(4): 615-618. https://doi.org/10.13493/j.issn.1672-7878.2020.04-053
    Abstract ( 85 ) Download PDF ( 5 )   Knowledge map   Save
    In December, 2019, Coronavirus disease (COVID-19) broke out in Wuhan, and quickly spread to the whole country. With the development of the epidemic, confirmed cases in many other countries were found. As a designated medical institution, the fifth people's hospital of Suzhou took actions immediately to deal with the epidemic. With the support of the leader of the hospital, the pharmaceutical department of the hospital set up an emergency team to adjust the working mode, improve the working efficiency, ensure the supply of drugs, and meet the needs of clinical treatment. At the same time, the pharmacists in the hospital stuck to their posts, and innovated the service model to provide various forms of pharmaceutical service for patients. All these work was useful to fight against the epidemic.